Equine paralytic (postoperative) ileus generally refers to an acute condition of impaired gastrointestinal motility. Paralytic ileus is most frequently seen following abdominal surgery on the small intestine in horses. Three main mechanisms are involved separately or simultaneously in its causation, namely neurogenicendocrinic, inflammatory-endotoxic and pharmacological mechanisms. Regardless of the cause, equine paralytic ileus can be fatal, if not properly diagnosed and treated. Over the past 22 years (1997-2019), we have diagnosed and treated more than 180 horses with postoperative ileus using differing methods. Based on our results and experience, and that of others, we have developed a multimodal strategy to reduce the incidence of postoperative ileus. This has resulted in effective treatment of ileus-diagnosed patients in 94% of cases, a significant improvement in survival rates over the last 20 years. In this review, we described pre-, intra-, and postoperative multiple supplementary preventative and treatment procedures that cure this condition. These methods are dependent on individual cases but include the control of endotoxemia and inflammation, as well as using the least traumatic surgical techniques, carrying out the pelvic flexure colotomy, improved anesthesia techniques, treating with continuous postoperative peritoneal lavage, the use of fluid, antibiotic and NSAIDs therapy, according to a scheme the use of different prokinetic agents (including metoclopramide, neostigmine methylsulfate and domperidone), nasogastric decompression, management to minimize the surgical and postoperative stress reaction and judicious timing of postoperative feeding of horses.An appreciation of the basic mechanisms that regulate gastrointestinal motility is a key component to understanding paralytic ileus. The musculature of the gastrointestinal tract in horses is made up of smooth muscle cells that are intimately associated, thus allowing them to conduct electrophysiological functions. There are three distinctive electrical potentials in the equine intestine: resting potential, slow-wave and spike potential that trigger contractions. Slow waves are rhythmic pacemaker currents initiated by the interstitial cells of Cajal (ICC). Normal gastrointestinal motility in horses results from very complex interactions among the enteric nervous system (ENS), autonomic and central nervous systems, ICC, gastrointestinal hormones, immune cells, glial cells and local factors that affect smooth-muscle activity [21,[23][24][25]. Extrinsically, the sympathetic nervous input through noradrenaline has an inhibitory effect on gastrointestinal motility, whereas parasympathetic input increases motility. The ENS is involved in all aspects of gastrointestinal function, not only motility, as well as by enteric processes such as immune responses, detecting nutrients, microvascular circulation, intestinal barrier function, and epithelial secretion of fluids and ions [10]. The neurons of the ENS are collected into two types of ganglia: myenteric (...