2023
DOI: 10.1002/1878-0261.13485
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Ex vivo mapping of enhancer networks that define the transcriptional program driving melanoma metastasis

Abstract: Mortality from vmelanoma is associated with metastatic disease, but the mechanisms leading to spreading of the cancer cells remain obscure. Spatial profiling revealed that melanoma is characterized by a high degree of heterogeneity, which is established by the ability of melanoma cells to switch between different phenotypical stages. This plasticity, likely a heritage from embryonic pathways, accounts for a relevant part of the metastatic potential of these lesions, and requires the rapid and efficient reorgan… Show more

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