Feijoa sellowianaBerg Fruit Juice: Anti-Inflammatory Effect and Activity on Superoxide Anion Generation

Abstract

Feijoa sellowiana Berg var. coolidge fruit juice was studied in vivo for the anti-inflammatory activity by carrageenin-induced paw edema test and in vitro for the effects on superoxide anion release from neutrophils in human whole blood. The fruit juice was analyzed by the high-performance liquid chromatography method, and quercetin, ellagic acid, catechin, rutin, eriodictyol, gallic acid, pyrocatechol, syringic acid, and eriocitrin were identified. The results showed a significant anti-inflammatory activity of F. sellowiana fruit juice, sustained also by an effective antioxidant activity observed in preliminary studies on 1,1-diphenyl-2-picrylhydrazyl (DPPH) test. In particular, the anti-inflammatory activity edema inhibition is significant since the first hour (44.11%) and persists until the fifth hour (44.12%) of the treatment. The effect on superoxide anion release was studied in human whole blood, in the presence of activators affecting neutrophils by different mechanisms. The juice showed an inhibiting response on neutrophils basal activity in all experimental conditions. In stimulated neutrophils, the higher inhibition of superoxide anion generation was observed at concentration of 10(-4) and 10(-2) mg/mL in whole blood stimulate with phorbol-myristate-13-acetate (PMA; 20% and 40%) and with N-formyl-methionyl-leucyl-phenylalanine (FMLP; 15% and 48%). The significant reduction of edema and the inhibition of O2(-) production, occurring mainly through interaction with protein-kinase C pathway, confirm the anti-inflammatory effect of F. sellowiana fruit juice.

Traceability of Opuntia ficus‐indica L. Miller by ICP‐MS multi‐element profile and chemometric approach

“…The operating conditions were optimized to obtain the highest signal-to-noise ratio for 7 Li, 59 Co, 115 In and 238 U with 140 Ce, 16 O/ 140 Ce < 2.5% and 140 Ce and 16 O < 5%. In particular, we used: RF power, 1500 W; plasma gas flow rate, 15 L min −1 ; auxiliary gas flow rate, 0.9 L min −1 ; carrier gas flow rate, 1.1 L min −1 ; helium collision gas flow rate, 4 mL min −1 ; spray chamber temperature, 2 ∘ C; sample depth, 9 mm; sample introduction flow rate, 1 mL min −1 ; nebulizer pump, 0.1 RPS; extract lens 1 voltage, 1.5 V. The instrument was used in no-gas mode for Mn, Pb, Zn, Mg, Ca, Na, K, and in helium mode for Ni, As, Se, Cd, Fe, Cu, to remove spectral interference.…”

“…3 This plant is extremely drought tolerant and grows abundantly under semiarid conditions; 4 in fact, a common feature of the areas where the plant grows is a more or less marked degree of aridity to which the plant has adapted as a result of its photosynthetic metabolism. 5 The cactus pear grows in all parts of the American continent, from southern Canada to southern Argentina, and in the course of time has been cultivated in different areas of Africa and Europe, especially in the Mediterranean area, like some other tropical fruits, [6][7][8] becoming a significant local crop. In particularly, Sicily (Italy) is the second-largest producer of Opuntia fruits in the world, 9,10 and the typical Sicilian variety of prickly pear, Opuntia ficus indica L. Miller, known as a symbol of this region, has gradually obtained increasing economic importance in agriculture, food and the cosmetics industry.…”

Path analysis for selection of feijoa with greater pulp weight

“…Feijoa fruit present translucent jelly-like pulp, with sweet acidulated flavor, and unique aroma (MATTOS, 1990). Due to its chemical composition, several studies have demonstrated the pharmacological properties of the species (WESTON, 2010), such as antibacterial, anti-inflammatory and antioxidant activities (KELES et al, 2012;MONFORTE et al, 2014); and to their antifungal activity against Candida glabrata, which is resistant to fluconazole (MACHADO et al, 2016).…”

Sexual Dimorphic Responses in Lymphocytes of Healthy Individuals after Carica papaya Consumption

“…Fruit extracts have been shown to modulate the immune system significantly even within a day of treatment (11, 13). Nevertheless, studies with long term treatments, e.g., of 33 days (12) to 70 days (10) also provide similar evidence of immunomodulatory responses.…”

“…Feijoa sellowiana Berg var. coolidge fruit juice consumption was shown to have anti-inflammatory activity on edema-induced mice within first hour of treatment (13) while agipenin, a natural flavonoid reduced neuroinflammation by protection against damage from dendritic cells stimulated T cells in experimental autoimmune encephlalomyelitis mouse models (14). Dietary polyphenols were found to exert a regulatory role on dendritic cell function.…”