1999
DOI: 10.1073/pnas.96.21.11895
|View full text |Cite
|
Sign up to set email alerts
|

Fgfr2 is required for limb outgrowth and lung-branching morphogenesis

Abstract: The aim of this study was to clarify the role of Fgfr2 during later stages of embryonic development. Of two previously reported gene-targeting experiments, the more extensive Fgfr2 deletion was lethal shortly after implantation, because of trophoblast defects, whereas the less extensive one survived until midgestation with placental insufficiency and defective limb outgrowth [Xu, X., Weinstein, M., Li, C., Naski, M., Cohen, R. I., Ornitz, D. M., Leder, P. & Deng, C. (1998) Development (Cambridge, U.K.) 125, 75… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

1
145
0

Year Published

2000
2000
2013
2013

Publication Types

Select...
5
2

Relationship

0
7

Authors

Journals

citations
Cited by 196 publications
(146 citation statements)
references
References 33 publications
(41 reference statements)
1
145
0
Order By: Relevance
“…Abnormal development of most of these organs has been documented previously in embryos carrying mutations in Fgfr2 (Arman et al, 1999;Celli et al, 1998;De Moerlooze et al, 2000;Revest et al, 2001;Xu et al, 1998). Therefore, we chose to study the earliest stages of eyelid and skin formation and patterning in Fgfr2 ⌬III/⌬III embryos, which have not been examined in detail.…”
Section: Multi-organ Abnormalities In Fgfr2 ⌬Iii/⌬iii Embryos Followimentioning
confidence: 74%
See 1 more Smart Citation
“…Abnormal development of most of these organs has been documented previously in embryos carrying mutations in Fgfr2 (Arman et al, 1999;Celli et al, 1998;De Moerlooze et al, 2000;Revest et al, 2001;Xu et al, 1998). Therefore, we chose to study the earliest stages of eyelid and skin formation and patterning in Fgfr2 ⌬III/⌬III embryos, which have not been examined in detail.…”
Section: Multi-organ Abnormalities In Fgfr2 ⌬Iii/⌬iii Embryos Followimentioning
confidence: 74%
“…In contrast, mouse embryos with a homozygous deletion of Fgfr2 Ig domain III (Fgfr2 ⌬lgIII/⌬lgIII ), which is shared by both FGFR2b and FGFR2c isoforms, died at E10.5 due to placental defects . Analysis of these mutant embryos revealed that FGFR2 is essential for induction and patterning of multiple organs, including limb, lung, inner ear, placenta, and skin (Arman et al, 1998(Arman et al, , 1999De Moerlooze et al, 2000;Pirvola et al, 2000;Revest et al, 2001;Xu et al, 1998). A similar observation was also made in embryos that overexpress a dominant-negative secreted Fgfr2 (Celli et al, 1998).…”
Section: Introductionmentioning
confidence: 99%
“…FGF-10 is expressed in the lung mesenchyme from the earliest stages of development and is critical for lung formation. By activating its receptor FGFR2b on adjacent epithelial cells, FGF-10 stimulates both proliferation and airway branching (2,3). Mice lacking either FGF-10 or FGFR2b develop only rudimentary lung structures containing tracheas but lacking bronchial airways (2,4).…”
mentioning
confidence: 99%
“…By activating its receptor FGFR2b on adjacent epithelial cells, FGF-10 stimulates both proliferation and airway branching (2,3). Mice lacking either FGF-10 or FGFR2b develop only rudimentary lung structures containing tracheas but lacking bronchial airways (2,4). During later stages of lung development, transgenic expression of an FGF-10 antagonist or addition of inhibitory antibodies disrupts normal airway elongation and branching (5)(6)(7).…”
mentioning
confidence: 99%
See 1 more Smart Citation