<i>Ficus deltoidea</i> Jack: A Review on Its Phytochemical and Pharmacological Importance

Bunawan, Hamidun; Amin, Noriha Mat; Bunawan, Siti Noraini; Baharum, Syarul Nataqain; Noor, Normah Mohd

doi:10.1155/2014/902734

Cited by 89 publications

(71 citation statements)

References 24 publications

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“…A wide range of chemical compounds have been isolated and characterized from F. deltoidea, particularly from the leaves and figs [5]. An initial comprehensive study 2009) isolated and identified moretenol from F. deltoidea leaves using nuclear magnetic resonance (NMR) and mass spectrometers [18].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of antimicrobial activity of Ficus species leaves extracts against Pseudomonas aeruginosa

Truchan¹,

Tkachenko²,

Buyun³

et al. 2015

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Section: Resultsmentioning

confidence: 99%

Evaluation of antimicrobial activity of Ficus species leaves extracts against Pseudomonas aeruginosa

Truchan¹,

Tkachenko²,

Buyun³

et al. 2015

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“…Those two species not only have been used as medicines for various ailments in the Malay Archipelago, but also pharmaceutically tested to have medicinal chemical compounds (see Table 5). Eurycoma longifolia and Ficus deltoidea have been distributed and formulated as capsules, tea, and tonic tea throughout Malaysia (Bunawan, Amin, Bunawan, Baharum, & Noor, 2014;Effendy, Mohammed, Muhammad, Mohammad, & Shuid, 2012). The species Arbus precatorius that is used to make easy and smooth the childbirth by the Kutai people in Menamang villages also used for the same efficacy in Guinea-Bissau and Ivory Coast.…”

Section: Species Identification Of Traditional Medicinal Plants Used mentioning

confidence: 99%

Species Identification of Traditional Medicine Plants for Women’s Health in East Kalimantan: Lesson Learned From Local Wisdom

Falah

Hadiwibowo²

2017

Ina.J.For.Res

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SPECIES IDENTIFICATION OF TRADITIONAL MEDICINE PLANTS FOR WOMEN'S HEALTH IN EAST KALIMANTAN: LESSON LEARNED FROM LOCAL WISDOM. Traditional communities inEast Kalimantan have been using traditional medicinal plants for centuries. This paper aims to identify the plant species used for traditional medicine for women's health in three tribes in East Kalimantan: Dayak Benuaq around Gunung Beratus Protection Forest, Dayak Bahau around Wehea Forest, and Kutai tribe around Kutai National Park. Medicinal plant species identification is important for plant breeding and developing utilization technology of those species. Data were collected by: 1) interview with traditional midwives and traditional medicinal plants users in those villages; 2) collecting the medicinal plant specimens in their natural habitat; 3) qualitative analysis of the interview records; 4) botanical identification of the specimens in Herbarium Wanariset Samboja; and 5) literature review about the usage of those medicinal plants by traditional communities in other places. This research result showed 44 medicinal plant species from 30 families for cosmetics, maternal uses, and women's reproductive health. The used parts of the medicinal plants were the roots, leaves, barks, stem, and fruits. The medicinal plants were processed by simple methods. There were 27 species also used by other communities for similar or different efficacies, and the active chemical compounds of 25 species have been known. The utilization of traditional medicinal plants are cheaper, more available, and accessible. However, the quality of the medicinal plants can not be guaranteed, and the dosage was not standardized. Therefore the medicinal plants need to be cultivated to ensure the quality and quantity, and to prevent species extinction. Keywords

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“…6,7 An anticancer research that was conducted to ovarian cancer cell lines, in vitro showed IC 50 values of 224.39 ± 6.24 pg/mL for FD aqueous extract and 143.03 ± 20.21 pg/mL forFD ethanolic extract. 2,8 A more extensive study on FD anticancer potential with other types of cancer, both in vitro and in vivo, needs to be performed. In Indonesia, colon cancer is the third most common cancer diagnosed after cervical and breast cancer.…”

Section: Introductionmentioning

confidence: 99%

In silico, in vitro and in vivo Tests of Ficus deltoidea Jack Leaves Extract as Inhibitor for Beta-Catenin Expression in Colon Carcinogenesis Model

Kusmardi¹,

Tedjo²,

Wuyung³

et al. 2018

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Context: Ficus deltoidea Jack leaves extract as anticolorectal cancer. Aims:This study aims to analyze the potential of FD extract to be an anti-colon cancer by investigating the extract capability in reducing β-catenin expression and inhibiting colon cancer cells growth. Settings |and Design: The research was conducted in Medical Faculty Universitas Indonesia with experimental design. Methods and Material: FD ethanol extracts was tested in vitro, in silico and in vivo. In vitro test was conducted to human colon cell lines. In vivo test was conducted to Balb/c mice induced with 10 mg/kg azoxymethane (AOM) and dextran sodium sulfate 1% (DSS). The colonic tissue collected was the distal portion. β-catenin expressions in the cytoplasm and nuclei of the epithelial cells of the colon crypt were semi quantitatively assessed using the immunohistochemistry staining on ten visual fields with 400x magnification. Statistical analysis used: SPSS. Results: FD ethanol extracts inhibit the expression of β-catenin in the crypt ephitelial cells of mice colon induced with AOM/DSS. The extracts also inhibit the growth of human colon cancer (HCT 116) with IC 50 value of 5.41 mg/mL. Phytochemical screening to the extracts gave three groups of compounds: alkaloid, flavonoid, and tannin. Water fraction is the best fraction. Based on in the results of in silico analysis with molecular docking, FD extract is believed to influence the expression of β-catenin, in which vitexin and isovitexin are the main candidate compounds to influence the expression of the protein. Conclusion: FD ethanol extract is potential to be an anti-colon cancer proven by the extract capability to reduce β-catenin expression.

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Ficus deltoidea Jack: A Review on Its Phytochemical and Pharmacological Importance

Cited by 89 publications

References 24 publications

Evaluation of antimicrobial activity of Ficus species leaves extracts against Pseudomonas aeruginosa

Evaluation of antimicrobial activity of Ficus species leaves extracts against Pseudomonas aeruginosa

Species Identification of Traditional Medicine Plants for Women’s Health in East Kalimantan: Lesson Learned From Local Wisdom

In silico, in vitro and in vivo Tests of Ficus deltoidea Jack Leaves Extract as Inhibitor for Beta-Catenin Expression in Colon Carcinogenesis Model

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