<i>Francisella tularensis</i>: an arthropod-borne pathogen

Petersen, Jeannine M.; Mead, Paul S.; Schriefer, Martin E.

doi:10.1051/vetres:2008045

Cited by 201 publications

(250 citation statements)

References 43 publications

(77 reference statements)

Supporting

Mentioning

243

Contrasting

Unclassified

Order By: Relevance

“…Given that adult male D. reticulates ticks do not take blood meals, this suggests that transstadial transmission may have occurred. Transovarial transmission of F. tularensis has however not been shown to occur experimentally in ticks, although there have been reports of infected unfed larvae in the field [65]. The prevalence rates detected in ticks have been mostly between 0% and 3% (Table 4).…”

Section: Ticksmentioning

confidence: 99%

The status of tularemia in Europe in a one-health context: a review

et al. 2014

View full text Add to dashboard Cite

SUMMARYThe bacterium Francisella tularensis causes the vector-borne zoonotic disease tularemia, and may infect a wide range of hosts including invertebrates, mammals and birds. Transmission to humans occurs through contact with infected animals or contaminated environments, or through arthropod vectors. Tularemia has a broad geographical distribution, and there is evidence which suggests local emergence or re-emergence of this disease in Europe. This review was developed to provide an update on the geographical distribution of F. tularensis in humans, wildlife, domestic animals and vector species, to identify potential public health hazards, and to characterize the epidemiology of tularemia in Europe. Information was collated on cases in humans, domestic animals and wildlife, and on reports of detection of the bacterium in arthropod vectors, from 38 European countries for the period 1992-2012. Multiple international databases on human and animal health were consulted, as well as published reports in the literature. Tularemia is a disease of complex epidemiology that is challenging to understand and therefore to control. Many aspects of this disease remain poorly understood. Better understanding is needed of the epidemiological role of animal hosts, potential vectors, mechanisms of maintenance in the different ecosystems, and routes of transmission of the disease.

show abstract

Section: Ticksmentioning

confidence: 99%

The status of tularemia in Europe in a one-health context: a review

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Several confirmed cases have been reported in the literature: immigrants from Ethiopia three months after they arrived in Israel, four French patients with unexplained fever from Senegal and a Dutch woman that developed symptoms after a twoweek trip to Guatemala and Belize (Sidi et al, 2005;Patrat-Delon et al, 2008;Heerdink et al, 2006). by physicians in Idaho, and one year later it was isolated from ticks (Petersen et al, 2009 (Aberer, 2009;Hubalek et al, 1996). In the U.S., Sweden, Finland and Russia, arthropod bites are a common mode of tularemia transmission to humans.…”

Section: Relapsing Fever Borreliosismentioning

confidence: 99%

“…In the U.S., Sweden, Finland and Russia, arthropod bites are a common mode of tularemia transmission to humans. In Central Europe, contact with infected animals and ingestion of contaminated food or water are more common modes of transmission (Hubalek et al, 1996;Petersen et al, 2009). The prevalence of tularemia in ticks is very low: only 0.01 % of 120,000 I. ricinus adult ticks in Russia were positive (Sjostedt, 2007a).…”

Section: Relapsing Fever Borreliosismentioning

confidence: 99%

Update on tick-borne bacterial diseases in Europe

et al. 2009

View full text Add to dashboard Cite

Summary :In recent years, the prevalence of tick-borne bacterial diseases has significantly increased in European countries. The emergence and reemergence of these illnesses are attributed to changes in the environment and human behavior. Several diseases are caused by bacteria initially isolated from ticks and subsequently considered pathogenic. It is necessary to consider the bacteria found in arthropods capable of biting humans as potential human pathogens. Here we review the clinical and epidemiological data on bacterial tick-borne diseases in European countries. We focus on the epidemiological and clinical aspects of tick-borne rickettsioses and give an overview of other tick-borne illnesses as well as the emergence and re-emergence of these diseases. Résumé : ACTUALITÉ SUR LES MALADIES BACTÉRIENNES TRANSMISES PAR

show abstract

“…Our future studies will determine whether the DISA method will provide a means to detect and monitor the emergence of new substrains of this highly infectious pathogen. Type A.I, A.II, and B strains of F. tularensis are present in North America, with hard ticks being considered the major biological vector of tularemia in this region (26). Since F. tularensis survival is sustained throughout the tick's life cycle from larva to nymph to adult, and since tick morphogenesis requires a blood meal, pathogen transmission to a new host may occur at each stage.…”

Section: Discussionmentioning

confidence: 99%

Francisella tularensis Molecular Typing Using Differential Insertion Sequence Amplification

et al. 2011

View full text Add to dashboard Cite

Tularemia is a potentially fatal disease that is caused by the highly infectious and zoonotic pathogen Francisella tularensis. Despite the monomorphic nature of sequenced F. tularensis genomes, there is a significant degree of plasticity in the organization of genetic elements. The observed variability in these genomes is due primarily to the transposition of direct repeats and insertion sequence (IS) elements. Since current methods used to genotype F. tularensis are time-consuming and require extensive laboratory resources, IS elements were investigated as a means to subtype this organism. The unique spatial location of specific IS elements provided the basis for the development of a differential IS amplification (DISA) assay to detect and distinguish the more virulent F. tularensis subsp. tularensis (subtypes A.I and A.II) and subsp. holarctica (type B) strains from F. tularensis subsp. novicida and other near neighbors, including Francisella philomiragia and Francisella-like endosymbionts found in ticks. Amplicon sizes and sequences derived from DISA showed heterogeneity within members of the subtype A.I and A.II isolates but not the type B strains. These differences were due to a 312-bp fragment derived from the IS element ISFtu1. Analysis of wild-type F. tularensis isolates by DISA correlated with pulsed-field gel electrophoresis genotyping utilizing two different restriction endonucleases and provided rapid results with minimal sample processing. The applicability of this molecular typing assay for environmental studies was demonstrated by the accurate identification and differentiation of tick-borne F. tularensis. The described approach to IS targeting and amplification provides new capability for epidemiological investigations and characterizations of tularemia source outbreaks.

show abstract

Francisella tularensis: an arthropod-borne pathogen

Cited by 201 publications

References 43 publications

The status of tularemia in Europe in a one-health context: a review

The status of tularemia in Europe in a one-health context: a review

Update on tick-borne bacterial diseases in Europe

Francisella tularensis Molecular Typing Using Differential Insertion Sequence Amplification

Contact Info

Product

Resources

About