<i>Francisella tularensis</i>
            Bacteremia

Haristoy, X.; Lozniewski, Alain; Tram, C.; Simeon, D.; Bevanger, Lars; Lion, C.

doi:10.1128/jcm.41.6.2774-2776.2003

Cited by 27 publications

(22 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In pneumonic, typhoidal or septic tularaemia, blood cultures are most promising. Frequently used commercial blood culture systems like BACTEC TM (BD), or BacT/Alert TM (bioMerieux, Hazelwood, IL, USA) were shown to give positive results in human tularaemia (Provenza et al., 1986; Haristoy et al., 2003). It remains to be determined if inoculation of samples from sterile sites (pleural fluid, liquor) into these blood culture systems may be superior to culture on solid media or in conventional broth (Brion et al., 1996).…”

Section: Bacteriological Specimen Examination For the Diagnosis Of Tumentioning

confidence: 99%

Diagnostic Procedures in Tularaemia with Special Focus on Molecular and Immunological Techniques

Splettstoesser

Tomaso

Dahouk

et al. 2005

Journal of Veterinary Medicine, Series B

View full text Add to dashboard Cite

Tularaemia is a severe bacterial zoonosis caused by the highly infectious agent Francisella tularensis. It is endemic in countries of the northern hemisphere ranging from North America to Europe, Asia and Japan. Very recently, Francisella-like strains causing disease in humans were described from tropical northern Australia. In the last decade, efforts have been made to develop sensitive and specific immunological and molecular techniques for the laboratory diagnosis of tularaemia and also for the definite identification of members of the species F. tularensis and its four subspecies. Screening for the keyword 'Francisella' a Medline search over the last decade was performed and articles describing diagnostic methods for tularaemia and its causative agent were selected. Besides classical microbiological techniques (cultivation, biochemical profiling, susceptibility testing) several new immunological and molecular approaches to identify F. tularensis have been introduced employing highly specific antibodies and various polymerase chain reaction (PCR)-based methods. Whereas direct antigen detection by enzyme-linked immunosorbent assay (ELISA) or immunofluorescence might allow early presumptive diagnosis of tularaemia, these methods--like all PCR techniques--still await further evaluation. Therefore, diagnosis of tularaemia still relies mainly on the demonstration of specific antibodies in the host. ELISA and immunoblot methods started to replace the standard tube or micro-agglutination assays. However, the diagnostic value of antibody detection in the very early clinical phase of tularaemia is limited. Francisella tularensis is regarded as a 'highest priority' biological agent (category 'A' according to the CDC, Atlanta, GA, USA), thus rapid and reliable diagnosis of tularaemia is required not only for a timely onset of therapy, the handling of outbreak investigations but also for the surveillance of endemic foci. Only very recently, evaluated test kits for serological diagnosis of human tularaemia became available, while the introduction of standardized molecular techniques for detection and typing is still missing.

show abstract

Section: Bacteriological Specimen Examination For the Diagnosis Of Tumentioning

confidence: 99%

Diagnostic Procedures in Tularaemia with Special Focus on Molecular and Immunological Techniques

Splettstoesser

Tomaso

Dahouk

et al. 2005

Journal of Veterinary Medicine, Series B

View full text Add to dashboard Cite

show abstract

“…The six strains isolated from France were from Chateneaux (AFIP3 and F0295), St. Germaine (AFIP4), Lorraine (FR-LauR), Langres (FR-Syl-S), and Vosges (F0020), implying that RD 23 -positive strains may be widespread in France. The FR-LauR and FR-Syl-S strains were isolated in 1993 and 2000, respectively, with the FR-Syl-S strain being isolated from one of the first cases of human F. tularensis bacteremia reported in Southern Europe (12). However, the F0020 strain was isolated in 1952, implying that the RD 23 -positive strains may have been in France for some time.…”

mentioning

confidence: 94%

Genomic Deletion Marking an Emerging Subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

Dempsey

Dobson

Zhang

et al. 2007

Appl Environ Microbiol

Self Cite

View full text Add to dashboard Cite

Francisella tularensis subsp. holarctica is widely disseminated in North America and the boreal and temperate regions of the Eurasian continent. Comparative genomic analyses identified a 1.59-kb genomic deletion specific to F. tularensis subsp. holarctica isolates from Spain and France. Phylogenetic analysis of strains carrying this deletion by multiple-locus variable-number tandem repeat analysis showed that the strains comprise a highly related set of genotypes, implying that these strains were recently introduced or recently emerged by clonal expansion in France and the Iberian Peninsula.

show abstract

“…Elle peut être réalisée sur du sang ou des ulcérations. Le prélèvement sur une lésion locale permet un diagnostic précoce [3,12,13] comme le montre notre cas. Une étude a comparé les aminosides, les tétracyclines et les quinolones.…”

Section: Discussionunclassified

Oropharyngeal tularemia: clustes of cases concerning 7 people

Lebourg¹,

Dufresne²,

Youssef³

et al. 2011

Ann. Fr. Med. Urgence

View full text Add to dashboard Cite

Francisella tularensis Bacteremia

Abstract: Bacteremia caused by Francisella tularensis is rare and has been reported mainly in the United States and infrequently in Europe. We report herein the first case of bacteremic F. tularensis pneumonia in an immunocompetent individual in southern Europe

Cited by 27 publications

References 29 publications

Diagnostic Procedures in Tularaemia with Special Focus on Molecular and Immunological Techniques

Diagnostic Procedures in Tularaemia with Special Focus on Molecular and Immunological Techniques

Genomic Deletion Marking an Emerging Subclone of Francisella tularensis subsp. holarctica in France and the Iberian Peninsula

Oropharyngeal tularemia: clustes of cases concerning 7 people

Contact Info

Product

Resources

About