<i>Francisella tularensis</i>in Rodents, China

Fang, Zhang; Liu, Wei; Chu, May C.; He, Jun; Duan, Qiangde; Wu, Xiaoming; Zhang, Pan-He; Zhao, Qin; Yang, Hong; Xin, Zhong-Tao; Cao, Wu‐Chun

doi:10.3201/eid1206.051324

Cited by 26 publications

(19 citation statements)

References 6 publications

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“…Importantly, ecological conditions and climate can significantly influence the rate of tularemia infection. For example, the rates of tularemia in wild rodents in six Chinese regions ranged from 0 to almost 12% (Zhang et al, 2006).…”

Section: Epidemiology Of Tularemiamentioning

confidence: 99%

“…The causative agent is transmittable to humans and can cause serious disease (Meric et al, 2010;Snowden and Stovall, 2010). Despite the relatively high number of tularemia-positive animals in the environment (Zhang et al, 2006;Treml et al, 2007), the total incidence in humans is on the decrease (Tarnvik and Berglunci, 2003). Game animals, and lagomorphs in particular (such as the European brown hare (Lepus europaeus)), are the most important sources of human infection (Hauri et al, 2010;Bandouchova et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review

Pohanka¹,

Chlíbek²,

Kuča³

et al. 2011

Vet. Med. - Czech

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Tularemia, an infection caused by the intracellular gram-negative bacterium Francisella tularensis, is accompanied by high mortality and occurs throughout the Northern Hemisphere. The causative agent is also considered one of the most important biological warfare agents. As well as its taxonomy and epidemiology, the basic immunochemical, biochemical, and molecular approaches for disease diagnosis are outlined in this review. Aspects of immune responses during tularemia and damage to specific organs are discussed with regards to the predictive value of standard biomarkers. Bacterial burden is also considered as a limitation for polymerase-chainreaction-based diagnosis. Keywords: Francisella tularensis; tularaemia; zoonosis; pathogenesis; assayList of abbreviations ALT = alanine aminotransferase, AST = aspartate aminotransferase, CFU = colony forming unit, GLU = glucose, IFN = interferon, iNOS = inducible nitric oxide synthase, LD = lactate dehydrogenase, LVS = live vaccine strain, PCR = polymerase chain reaction, TNF = tumour necrosis factor

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Section: Epidemiology Of Tularemiamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review

Pohanka¹,

Chlíbek²,

Kuča³

et al. 2011

Vet. Med. - Czech

View full text Add to dashboard Cite

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“…Subspecies holartica (subtype B; can be referred to as palaeartica) is found in North America as well as in Eurasia. Zhang et al (2006) proved that this subspecies was present in nearly 5 % of rodents in China. The holarctica subspecies can be divided into three biovars (Olsufjev and Meshcheryakova 1983): the erythromycin-sensitive biovar I, erythromycin-resistant biovar II and biovar japonica.…”

Section: Introductionmentioning

confidence: 96%

Bacillus anthracis, Francisella tularensis and Yersinia pestis. The most important bacterial warfare agents — review

Pohanka¹,

Skládal

2009

Folia Microbiol

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There are three most important bacterial causative agents of serious infections that could be misused for warfare purposes: Bacillus anthracis (the causative agent of anthrax) is the most frequently mentioned one; however, Fracisella tularensis (causing tularemia) and Yersinia pestis (the causative agent of plague) are further bacterial agents enlisted by Centers for Disease Control and Prevention into the category A of potential biological weapons. This review intends to summarize basic information about these bacterial agents. Military aspects of their pathogenesis and the detection techniques suitable for field use are discussed.

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“…The human population can be simply infected too, especially by arthropod vectors such as ticks, flies and mosquitoes. For example, 2.1 -2.8% of Dermacentor reticulatus are natural vectors of F. tularensis in the middle Europe [2], and nearly 5% of rodents in China are suffering or at least vectors of F. tularensis [3]. In another study it was pointed out that 3.1% of wild boars in Germany possess antibodies against F. tularensis [4].…”

Section: Introductionmentioning

confidence: 99%

Serological Diagnosis of Tularemia in Mice Using the Amperometric Immunosensor

Pohanka

Skládal

2007

Electroanalysis

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Tularemia caused by the bacterium Francisella tularensis belongs to danger infective diseases, therefore timely diagnosis is an important part of protective activities. A novel approach for serological diagnostics of tularemia using a four-channel amperometric immunosensor was proposed and evaluated on BALB/c mice as a model organism. The immunosensor was able to work with small volumes of serum samples (0.05 mL per assay) and diagnosed tularemic infection very early after immunization. From the 5 th day, it was possible to distinguish tularemic sera from control sera from mice immunized with Escherichia coli on the probability level of 0.99 (t-test). Some 40 measurements per one hour can be realized with the developed procedure. The obtained results were confirmed by the standard indirect ELISA. The proposed immunosensor-based approach seems promising for rapid detection of microbial pathogen infections.

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Francisella tularensisin Rodents, China

Cited by 26 publications

References 6 publications

Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review

Diagnosis of tularemia using biochemical, immunochemical and molecular methods: a review

Bacillus anthracis, Francisella tularensis and Yersinia pestis. The most important bacterial warfare agents — review

Serological Diagnosis of Tularemia in Mice Using the Amperometric Immunosensor

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