<i>Fructus mume</i> Protects Against Cigarette Smoke Induced Chronic Cough Guinea Pig

Xiang, Jun; Liu, Xiao-dong; Zhong, Shan; Zheng, Fang; Shen, Shuirong; Tang, Jiaman; Lai, Siqi; Lai, Kefang

doi:10.1089/jmf.2019.4423

Cited by 13 publications

(5 citation statements)

References 26 publications

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“…Growing evidence suggests that the major components of MF, including flavonoids, sterols, and organic acids, have multiple pharmacologic functions, such as bacteriostasis, antitumor activity, and regulating gut microbiota. Citric acid, chlorogenic acid, and neochlorogenic acid in MF can significantly alleviate cough and airway inflammation, inhibit the overproduction of mucus, and thus reduce chronic cough resulting from tobacco smoke in a guinea pig model [ 59 ]. Xing et al illustrated that MF extracts could alleviate diarrhea caused by the combined treatment of lapatinib and Xeloda for breast cancer patients [ 60 ].…”

Section: Discussionmentioning

confidence: 99%

Characterizing the Antitumor Effect of Coptis chinensis and Mume Fructus against Colorectal Cancer Based on Pharmacological Analysis

Gao

2022

Evidence-Based Complementary and Alternative Medicine

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Colorectal cancer (CRC) is the third most diagnosed cancer worldwide and is a significant cause of cancer-related deaths. Previous studies have observed that Coptis chinensis (CC) and Mume Fructus (MF) are effective against CRC, enteritis, and intestinal dysbiosis, but the chemical and pharmacological mechanisms remain poorly understood. In this study, we employed pharmacological network analysis to reveal mechanisms underlying the therapeutic effect of CC and MF against CRC. All compounds and targeted genes were obtained from the traditional Chinese medicine systems pharmacology database and analysis platform (TCMSP). Differentially expressed genes (DEGs) were identified based on GSE146587, GSE156720, and GSE184093 datasets. A protein-protein interaction (PPI) network was constructed to identify putative target genes of CC and MF. Ten key targeted genes were identified, including CCND1, ICAM1, IL1B, IL-6, MMP1, MMP3, MMP9, MYC, SERPINE1, and VEGFA. Among these genes, six (ICAM1, IL1B, IL-6, MMP1, MMP3, MMP9, and SERPINE1) were positively correlated with levels of effector memory CD4 T cells and natural killer T cells, and three (CCND1, MYC, and VEGFA) were negatively correlated with type 17 T helper cells and CD56dim natural killer cells. Molecular docking analysis showed that four compounds of CC and MF (kaempferol, oleanolic acid, quercetin, and ursolic acid) could affect CRC by interacting with target genes. Our study proved that pharmacological analysis could reliably assess the mechanism of traditional Chinese medicines for treating cancer.

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Section: Discussionmentioning

confidence: 99%

Characterizing the Antitumor Effect of Coptis chinensis and Mume Fructus against Colorectal Cancer Based on Pharmacological Analysis

Gao

2022

Evidence-Based Complementary and Alternative Medicine

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“…TCMs are considered better alternatives for improving animal health and resisting infectious diseases. Fructus mume (“wumei” in Chinese) has long been used in China to treat chronic coughs, expectoration, ulceration, chronic diarrhea, and gastrointestinal diseases [ 39 , 40 , 41 , 42 , 43 , 44 ]. This medicinal effect is due to its antioxidant [ 44 ], antibacterial [ 45 ], and anti-inflammatory properties [ 43 , 44 ], and its protective ability against gastrointestinal diseases via the opsonization of intestinal commensal bacteria, as well as its ability to alleviate epithelial injury and inflammation [ 39 ].…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Fructus mume and Scutellaria baicalensis Georgi on the Fecal Microbiota and Its Correlation with Apparent Nutrient Digestibility in Weaned Piglets

Zhang

Jin

Liu

et al. 2022

Animals

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Traditional Chinese medicine (TCM) has long been demonstrated to exert a therapeutic effect on various diseases and has been used as a substitute for antibiotics in pig production. However, few studies have investigated the relationship between the intestinal microbiota and apparent nutrient digestibility when weaned piglet diets are supplemented with TCM. One hundred and sixty-two 25-day-old weaning piglets were housed in an environmentally controlled nursery facility and fed a basal diet (control group, n = 54) or a TCM complex (Fructus mume 1%, Scutellaria baicalensis Georgi 3%) (TCM group, n = 54), or a fermented diet with a complex of these two TCMs (F-TCM group, n = 54). Compared with the control group, in the TCM and F-TCM groups, the average daily gain (ADG) increased (p < 0.05), the F:G ratio and diarrhea rate decreased (p < 0.05), and the apparent digestibility of dry matter (DM) and ether extract (EE) of weaned piglets increased (p < 0.05). Bacteroidetes and Firmicutes were the predominant phyla, representing approximately 95% of all sequences. The abundance of four genera and 10 OTUs (belonging to Ruminococcaceae_UCG-014, Lachnoclostridium, Prevotellaceae_NK3B31 group, Prevotella_1) were negatively correlated with apparent EE digestibility (p < 0.05). The results suggest that weaned piglets fed with antibiotic-free diets supplemented with Fructus mume and Scutellaria baicalensis Georgi gained more weight and were healthier. When added to the diet, the complex of these two TCMs may have a direct impact on apparent EE digestibility by modifying the gut microbial composition, which favors the health of weaned piglets.

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“…The content of polysaccharides in PFC is about 75.30%. Previous study has reported the number-average and weight-average molecular weights of the polysaccharides were 1.60 kDa and 1.68 kDa and the main monosaccharides were galactose (41.49%), glucose (36.45%), arabinose (9.14%), mannose (4.92%), ribose (4.34%), and xylose (3.23%) ( Xiang et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of polysaccharides-riched Prunus mume fruit juice concentrate on uric acid excretion and gut microbiota in mice with adenine-induced chronic kidney disease

Huang

Guo

et al. 2022

Current Research in Food Science

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Fructus mume Protects Against Cigarette Smoke Induced Chronic Cough Guinea Pig

Cited by 13 publications

References 26 publications

Characterizing the Antitumor Effect of Coptis chinensis and Mume Fructus against Colorectal Cancer Based on Pharmacological Analysis

Characterizing the Antitumor Effect of Coptis chinensis and Mume Fructus against Colorectal Cancer Based on Pharmacological Analysis

Effect of Dietary Fructus mume and Scutellaria baicalensis Georgi on the Fecal Microbiota and Its Correlation with Apparent Nutrient Digestibility in Weaned Piglets

Effects of polysaccharides-riched Prunus mume fruit juice concentrate on uric acid excretion and gut microbiota in mice with adenine-induced chronic kidney disease

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