<i>Fusobacterium necrophorum</i> subsp. <i>necrophorum</i> Liver Abscess with Pylephlebitis: An Abdominal Variant of Lemierre’s Syndrome

Radovanović, Nataša; Dumić, Igor; Veselinovic, Mladjen; Burger, Susanne; Milovanović, Tamara; Nordstrom, Charles W.; Niendorf, Eric; Ramanan, Poornima

doi:10.1155/2020/9237267

Cited by 20 publications

(24 citation statements)

References 24 publications

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“…Abdominal pain, out of proportion to physical findings, is a hallmark of porto-mesenteric thrombosis, typically associated with fever and leukocytosis [ 4 ]. Abdominal pain was encountered in all cases, either generalized from the beginning, of high intensity, or firstly localized in the epigastrium or the mezogastric area.…”

Section: Resultsmentioning

confidence: 99%

“…Several systemic conditions, such as arterial hypertension, atrial fibrillation, atherosclerosis, heart failure, or valve disease are risk factors for AMI. Portal vein thrombosis and mesenteric vein thrombosis can be seen with celiac disease [ 2 ], appendicitis [ 3 ], pancreatitis [ 4 ], and, in particular, liver cirrhosis and hepatocellular cancer [ 5 ].…”

Section: Introductionmentioning

confidence: 99%

“…ACE2 receptors are present at the level of the intestinal wall, and enterocytes may be directly infected by SARS-CoV-2. The virus was evidenced in feces and enteral walls in infected subjects [ 4 , 11 , 12 , 13 ]. In a study by Xu et al, rectal swabs were positive in 8 of 10 pediatric patients, even after the nasopharyngeal swabs became negative [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Acute Mesenteric Ischemia in COVID-19 Patients

Serban

Tribus

Vancea

et al. 2021

JCM

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Acute mesenteric ischemia is a rare but extremely severe complication of SARS-CoV-2 infection. The present review aims to document the clinical, laboratory, and imaging findings, management, and outcomes of acute intestinal ischemia in COVID-19 patients. A comprehensive search was performed on PubMed and Web of Science with the terms “COVID-19” and “bowel ischemia” OR “intestinal ischemia” OR “mesenteric ischemia” OR “mesenteric thrombosis”. After duplication removal, a total of 36 articles were included, reporting data on a total of 89 patients, 63 being hospitalized at the moment of onset. Elevated D-dimers, leukocytosis, and C reactive protein (CRP) were present in most reported cases, and a contrast-enhanced CT exam confirms the vascular thromboembolism and offers important information about the bowel viability. There are distinct features of bowel ischemia in non-hospitalized vs. hospitalized COVID-19 patients, suggesting different pathological pathways. In ICU patients, the most frequently affected was the large bowel alone (56%) or in association with the small bowel (24%), with microvascular thrombosis. Surgery was necessary in 95.4% of cases. In the non-hospitalized group, the small bowel was involved in 80%, with splanchnic veins or arteries thromboembolism, and a favorable response to conservative anticoagulant therapy was reported in 38.4%. Mortality was 54.4% in the hospitalized group and 21.7% in the non-hospitalized group (p < 0.0001). Age over 60 years (p = 0.043) and the need for surgery (p = 0.019) were associated with the worst outcome. Understanding the mechanisms involved and risk factors may help adjust the thromboprophylaxis and fluid management in COVID-19 patients.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Acute Mesenteric Ischemia in COVID-19 Patients

Serban

Tribus

Vancea

et al. 2021

JCM

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“…septicemia [4]. We hereby report a case of septic portomesenteric thrombosis secondary to Fusobacterium necrophorum bacteremia in the setting of sigmoid colitis to add to a total of 21 cases of Fusobacterium-spp.-infection-related pylephlebitis reported in the literature [8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: Discussionmentioning

confidence: 93%

A Rare Twist of the Forgotten Disease: A Case of Fusobacterium necrophorum Sepsis with Portomesenteric Thrombosis and a Review of the Literature

Lazar

Sardarli

Imam

et al. 2021

Case Reports in Gastrointestinal Medicine

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Abdominal variants of Lemierre’s syndrome presenting with pylephlebitis are rare, and the role of anticoagulation in treatment is controversial. We hereby report a case of pylephlebitis secondary to F. necrophorum bacteremia in a 57-year-old female originating from bacterial translocation secondary to colitis, who developed a favorable outcome with prompt treatment with antibiotics and anticoagulation. We also perform a literature review on similar cases in the literature and discuss management options of this rare but potentially fatal complication.

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“… 14 Review of the literature revealed one case report of splenic abscesses associated with hepatic abscesses and the gastrointestinal variant of Lemierre’s syndrome. 14 , 15 Fusobacterium spp. are susceptible to a broad spectrum of antibiotics, with small numbers of isolates demonstrating penicillin and erythromycin resistance.…”

Section: Discussionmentioning

confidence: 99%

An unusual case of abdominal pain and splenomegaly in a paediatric patient

Eckbo

Mijović

Tam

et al. 2021

SAGE Open Medical Case Reports

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Fusobacterium species are members of the oral microbiota and have been found to cause a wide spectrum of opportunistic infections. We describe the case of a previously healthy teenager with a large splenic abscess secondary to Fusobacterium nucleatum, successfully managed with percutaneous drainage and intravenous antibiotics. Identification of the organism was achieved using anaerobic culture of the aspirated fluid and matrix-assisted laser desorption/ionization time of flight, later confirmed by 16S ribosomal RNA metagenomic sequencing of the fluid. Fusobacteria are typically associated with oropharyngeal infections but are very rarely implicated in splenic abscesses. Aerobic and anaerobic blood cultures should be drawn when an intra-abdominal infection is suspected in a paediatric patient, and empiric antimicrobial therapy should be administered with coverage for gram-positive, gram-negative, and anaerobic bacteria.

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Fusobacterium necrophorum subsp. necrophorum Liver Abscess with Pylephlebitis: An Abdominal Variant of Lemierre’s Syndrome

Cited by 20 publications

References 24 publications

Acute Mesenteric Ischemia in COVID-19 Patients

Acute Mesenteric Ischemia in COVID-19 Patients

A Rare Twist of the Forgotten Disease: A Case of Fusobacterium necrophorum Sepsis with Portomesenteric Thrombosis and a Review of the Literature

An unusual case of abdominal pain and splenomegaly in a paediatric patient

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