<i>Fusobacterium nucleatum</i>
            induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling

Udayasuryan, Barath; Ahmad, Raffae N.; Nguyen, Tam T.D.; Umaña, Ariana; Roberts, LaDeidra Monét; Sobol, Polina; Jones, Stephen D.; Munson, Jennifer M.; Slade, Daniel J.; Verbridge, Scott S.

doi:10.1126/scisignal.abn4948

Cited by 60 publications

(42 citation statements)

References 82 publications

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“…Moreover, F. nucleatum enhances the secretion of pro-inflammatory cytokines, such as cyclooxygenase-2, interleukin (IL)-8, IL-6, IL-1ß, and tumor necrosis factor alpha (TNF-α) [39]. Similar results were found in pancreatic cancer, when both infected normal and pancreatic cancer cells secreted increased amounts of the cytokines Granulocyte-macrophage colony-stimulating factor, C-X-C motif ligand 1 (CXCL1), IL-8, and MIP-3α, known to increase proliferation, migration, and invasive cell motility [40 ▪ ]. Also, F. nucleatum can induce inflammation in CRC cells by promoting the production of reactive oxygen species (ROS) [41].…”

Section: Fusobacteria In (Oral) Cancermentioning

confidence: 56%

The role of Fusobacteria in oral cancer and immune evasion

Harrandah

2023

Current Opinion in Oncology

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Purpose of reviewThere is growing evidence that suggests a possible role for bacteria in the progression of cancer. Fusobacteria have been detected in different types of cancers, including colorectal and oral cancers. Fusobacteria are common opportunistic oral bacteria known to cause various infections. In this review, we focus on the association between Fusobacteria and cancer, specifically oral cancer, and provide insight into the role of Fusobacteria in carcinogenesis and immune evasion.Recent findingsRecently, it has been suggested that Fusobacteria are among the bacteria that contribute to the progression of cancer and might affect disease prognosis and treatment outcome. Moreover, Fusobacteria might alter tumor microenvironment and have an impact on tumor immune response. Thus, understanding the effect of Fusobacteria on cancer cells and tumor microenvironment is crucial to improve treatment outcome.SummeryRecent evidences suggest that Fusobacteria not only have an impact on tumor progression, but might also affect tumor immune response. Moreover, Fusobacteria presence in the tumor microenvironment might have an impact on treatment outcome and might be used as a prognostic factor.

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Section: Fusobacteria In (Oral) Cancermentioning

confidence: 56%

The role of Fusobacteria in oral cancer and immune evasion

Harrandah

2023

Current Opinion in Oncology

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“…In addition, NF-κB plays an important role in regulating the survival, activation and differentiation of immune cells. Of particular interest, this signaling pathway is involved in promoting cell proliferation and closely related to cancer development and progression, of which is promotion of proliferation of pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer [ 129 , 131 ] ( Figure 3 ).…”

Section: Virulence Factors Of Periodontal Pathogens and Their Associa...mentioning

confidence: 99%

Virulence Factors of the Periodontal Pathogens: Tools to Evade the Host Immune Response and Promote Carcinogenesis

2023

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Periodontitis is the most common chronic, inflammatory oral disease that affects more than half of the population in the United States. The disease leads to destruction of the tooth-supporting tissue called periodontium, which ultimately results in tooth loss if uncured. The interaction between the periodontal microbiota and the host immune cells result in the induction of a non-protective host immune response that triggers host tissue destruction. Certain pathogens have been implicated periodontal disease formation that is triggered by a plethora of virulence factors. There is a collective evidence on the impact of periodontal disease progression on systemic health. Of particular interest, the role of the virulence factors of the periodontal pathogens in facilitating the evasion of the host immune cells and promotion of carcinogenesis has been the focus of many researchers. The aim of this review is to examine the influence of the periodontal pathogens Aggregatibacter actinomycetemcomitans (A. actinomycetemcomitans), Porphyromonas gingivalis (P. gingivalis), and Fusobacterium nucleatum (F. nucleatum) in the modulation of the intracellular signaling pathways of the host cells in order to evade the host immune response and interfere with normal host cell death and the role of their virulence factors in this regard.

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“…Udayasuryan et al found that F. nucleatum infection increased the secretion of granulocyte-macrophage colony-stimulating factor (GM-CSF), CXCL1, IL-8, and macrophage inflammatory protein 3α, which could contribute to the accumulation of MDSCs in the TMA. It could be that GM-CSF promotes the proliferation of pancreatic cancer cells [ 2 , 51 ]. In addition, the inflammasome PRR is involved in the formation of a protein complex that activates inflammatory pathways through the recognition of PAMPs or DAMPs by associated receptors, and inflammasome defects cause inflammation-induced colorectal cancer [ 4 ].…”

Section: Mechanism Of the Role Of Intra-tumorigenic Bacteria In Tumor...mentioning

confidence: 99%

Awareness of intratumoral bacteria and their potential application in cancer treatment

Yin

Liu

et al. 2023

Discov Onc

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Hitherto, the recognition of the microbiota role in tumorigenesis and clinical studies mostly focused on the intestinal flora. In contrast to the gut microbiome, microorganisms resident in tumor tissue are in close contact with cancer cells and therefore have the potential to have similar or even different functional patterns to the gut flora. Some investigations have shown intratumoral bacteria, which might come from commensal microbiota in mucosal areas including the gastrointestinal tract and oral cavity, or from nearby normal tissues. The existence, origin, and interactions of intratumoral bacteria with the tumor microenvironment all contribute to intratumoral microorganism heterogeneity. Intratumoral bacteria have a significant role in tumor formation. They can contribute to cancer at the genetic level by secreting poisons that directly damage DNA and also intimately related to immune system response at the systemic level. Intratumoral bacteria have an impact on chemotherapy and immunotherapy in cancer. Importantly, various properties of bacteria such as targeting and ease of modification make them powerful candidates for precision therapy, and combining microbial therapies with other therapies is expected to improve the effectiveness of cancer treatment. In this review, we mainly described the heterogeneity and potential sources of intratumoral bacteria, overviewed the important mechanisms by which they were involved in tumor progression, and summarized their potential value in oncology therapy. At last, we highlight the problems of research in this field, and look forward to a new wave of studies using the various applications of intratumoral microorganisms in cancer therapy.

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Fusobacterium nucleatum induces proliferation and migration in pancreatic cancer cells through host autocrine and paracrine signaling

Cited by 60 publications

References 82 publications

The role of Fusobacteria in oral cancer and immune evasion

The role of Fusobacteria in oral cancer and immune evasion

Virulence Factors of the Periodontal Pathogens: Tools to Evade the Host Immune Response and Promote Carcinogenesis

Awareness of intratumoral bacteria and their potential application in cancer treatment

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