Galega officinalisL. and Immunological Status in Diabetes Mellitus

Abstract

Under diabetes mellitus, the administration of Galega officinalis promotes restoration of leukocyte precursors' bone marrow pool and normalizes their proliferative activity. This plant protects the functional state of leukocytes by modulating actin cytoskeleton formation and through quantitative redistribution of leukocyte membrane glycoconjugates. Galega officinalis prevents the development of diabetesassociated oxidative stress which results in antiapoptotic activity. The normalization of leukocytes' proliferative and functional capacity by Galega officinalis, along with its antiapoptotic and hypoglycemic effects, can improve the course of the disease and may prevent the development of complications of diabetes.

A Review on Futuristic Scope of Agents Related to Amphibian’s Skin and Plants-based Sources in Type 2 Antidiabetic Therapies

“…Additionally, the drug Metformin widely used in modern era in diabetes is also derived from plant Galega officinalis. [59] However, decades of research on variety of such amphibian's skin/ plants-based agents none of the steadfast and economical solutions has been achieved till date countering type 2 form of diabetes and its related complications. Based on this fact the current review here aims to discuss unique and less widely explored agents from natural sources like insulinotropic peptides isolated from frog skin secretions belonging to class Pipidae and agents from marine/local plants (Laguncularia racemosa, Pterocarpus marsupium and Cymodocea nodosa) bearing immense potential to be transformed into vital futuristic therapy against type-2 Diabetes.…”