<i>GALNT14</i>
            Genotype Effectively Predicts The Therapeutic Response in Unresectable Hepatocellular Carcinoma Treated with Transcatheter Arterial Chemoembolization

Liang, Kung–Hao; Lin, Chih Lang; Chen, Sung Fang; Chiu, Chih Wei; Yang, Pei Ching; Chang, Ming; Chen, Lin; Sung, Kai Feng; Yeh, Cassandra; Hung, Chien Fu; Chien, Rong Nan; Yeh, Chau Ting

doi:10.2217/pgs.15.179

Cited by 25 publications

(33 citation statements)

References 36 publications

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“…Recently, GALNT14 has been shown to be associated with neuroblastoma, hepatocarcinoma, and lung adenocarcinoma216667. Furthermore, elevated GALNT14 expression has been proposed as a biomarker for TRAIL-sensitive tumours60.…”

Section: Discussionmentioning

confidence: 99%

GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment

et al. 2016

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Some polypeptide N-acetyl-galactosaminyltransferases (GALNTs) are associated with cancer, but their function in organ-specific metastasis remains unclear. Here, we report that GALNT14 promotes breast cancer metastasis to the lung by enhancing the initiation of metastatic colonies as well as their subsequent growth into overt metastases. Our results suggest that GALNT14 augments the self-renewal properties of breast cancer cells (BCCs). Furthermore, GALNT14 overcomes the inhibitory effect of lung-derived bone morphogenetic proteins (BMPs) on self-renewal and therefore facilitates metastasis initiation within the lung microenvironment. In addition, GALNT14 supports continuous growth of BCCs in the lung by not only inducing macrophage infiltration but also exploiting macrophage-derived fibroblast growth factors (FGFs). Finally, we identify KRAS-PI3K-c-JUN signalling as an upstream pathway that accounts for the elevated expression of GALNT14 in lung-metastatic BCCs. Collectively, our findings uncover an unprecedented role for GALNT14 in the pulmonary metastasis of breast cancer and elucidate the underlying molecular mechanisms.

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Section: Discussionmentioning

confidence: 99%

GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment

et al. 2016

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“…Early stage HCC can be treated surgically, by ablation procedures or by liver transplantation [13]. Hepatitis B and C viruses are the main causes of HCC [14].…”

Section: Galnt 14 and Hepatocellular Carcinomamentioning

confidence: 99%

“…According to recent studies, a single nucleotide polymorphism on GALNT14 is shown to be associated with the therapeutic response to combined chemotherapy in cases with advanced HCC. The gene region that encoded GALNT14 associated to time-to-progression and survival in patinets with HCC [12,13].…”

Section: Galnt 14 and Hepatocellular Carcinomamentioning

confidence: 99%

Critical Role of a Novel Biological Marker GALNT14 Expression in Different Cancer Types

Turğut¹

2017

J Brain Tumors Neurooncol

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“…Recently, the genotypes of the GALNT14 -rs9679162 single nucleotide polymorphism (SNP) has been shown to be an effective predictor for systemic chemotherapy response in advanced hepatocellular carcinoma (HCC), based on a genome-wide exploration of 500,000 SNPs in human white blood cells [23], and subsequent prospective [24] and retrospective validations [25, 26]. This genotype was further demonstrated to be an effective outcome predictor of transcatheter arterial chemoembolization treatment (TACE) for intermediate-stage HCC patients [27]. In all these studies, the GALNT14 rs9679162 “T” allele was associated to favorable outcomes of patients, while the “G” allele was associated to poor outcomes.…”

Section: Introductionmentioning

confidence: 99%

“…The systemic combination chemotherapy regimens used for the previous studies were 5- fluorouracil, cisplatin and mitoxantrone, of which two were commonly used for advanced ESCC. Furthermore, the GALNT14 protein has been shown to be able to enhance the extrinsic apoptotic signaling of cancer cells [27, 28]. It would be interesting to know if GALNT14 genotype could be a predictor of chemoradiotherapeutic response in patients with advanced ESCC.…”

Section: Introductionmentioning

confidence: 99%

GALNT14 genotype as a response predictor for concurrent chemoradiotherapy in advanced esophageal squamous cell carcinoma

et al. 2017

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Esophageal squamous cell carcinoma is an aggressive cancer. We investigated genetic response predictors for patients with advanced esophageal squamous cell carcinoma receiving concurrent chemoradiotherapy. A cohort of 108 patients was recruited. Survival analysis showed that lower esophageal location of tumor, more advanced metastasis stage, and longer length of tumor were associated with poorer overall survival (adjusted P = 0.001, < 0.001, and 0.045, respectively), while the presence of complete/partial response to concurrent chemoradiotherapy was independently associated with better overall survival (adjusted P < 0.001). The GALNT14-rs9679162 “GG” genotype was associated with a lower rate of response (P = 0.014). Multivariate Cox-proportional hazards models also showed that the “GG” genotype was associated with a longer time to complete/partial response (adjusted P = 0.022), independent of leukocyte counts and gender. In conclusion, the presence of a complete/partial response to chemoradiotherapy was critical for advanced esophageal squamous cell carcinoma patients to achieve better overall survival. The GALNT14-rs9679162 “GG” genotype was associated with a longer time to complete/partial response of concurrent chemoradiotherapy.

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GALNT14 Genotype Effectively Predicts The Therapeutic Response in Unresectable Hepatocellular Carcinoma Treated with Transcatheter Arterial Chemoembolization

Abstract: GALNT14 genotypes were significantly associated with clinical outcomes of transcatheter arterial chemoembolization. The differential status of extrinsic apoptotic signaling between cancerous and non-cancerous tissues might underlie the clinical association.

Cited by 25 publications

References 36 publications

GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment

GALNT14 promotes lung-specific breast cancer metastasis by modulating self-renewal and interaction with the lung microenvironment

Critical Role of a Novel Biological Marker GALNT14 Expression in Different Cancer Types

GALNT14 genotype as a response predictor for concurrent chemoradiotherapy in advanced esophageal squamous cell carcinoma

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