Ganoderma lucidum culture supplement ameliorates dyslipidemia and reduces visceral fat accumulation in type 2 diabetic rats

Abstract

Diabetic rats were daily fed with a high-cholesterol diet containing 1% or 3% freeze-dried whole submerged G. lucidum culture or its mycelia for 5 weeks. Body weight, adipose tissue weight and plasma triglyceride levels were reduced, while high-density lipoprotein-cholesterol levels were elevated in rats fed with G. lucidum powder supplement diets. Notably, G. lucidum supplements downregulated the activities of hepatic acetyl-CoA carboxylase, fatty acid synthase and lipoprotein lipase, but upregulated the activity of hormone-sensitive lipase in the perirenal adipose tissues. Moreover, G. lucidum supplements increased the faecal triglyceride excretion. Therefore, daily supplementation of submerged G. lucidum culture, especially mycelia, can ameliorate dyslipidemia and reduce visceral fat accumulation in diabetic rats fed with a high-fat diet, which is closely related to the modulation of lipid synthesis, metabolism, and excretion.

Effects of different graphene‐based nanomaterials as elicitors on growth and ganoderic acid production by Ganoderma lucidum

“…28,29 G. lucidum is one of the most well-known medicinal mushrooms and has been used for its therapeutic effects for more than 2,000 years. [31][32][33][34] GAs are the most significant secondary metabolites of G. lucidum and have many potential therapeutic applications, as claimed by numerous literature. 35,36 There is a considerable amount of researches that describes the influence of different parameters on growth and GA production of G. lucidum, such as optimization of fermentation conditions, elicitation, and molecular biology technique to achieve higher expression of GA biosynthesis-related genes.…”

“…In the last two decades, numerous studies have explored the active components of G. lucidum and their biological effects along with underlying mechanisms of action 30 . To date, over 300 active compounds have been isolated from G. lucidum with numerous biological activities, including anti‐inflammatory, immune regulation, anti‐tumor, hepatoprotective, hypoglycemic, anti‐aging, neuroprotection, and antioxidant activities 31‐34 . GAs are the most significant secondary metabolites of G. lucidum and have many potential therapeutic applications, as claimed by numerous literature 35,36 .…”

Protective effect of Ganoderma lucidum-fermented crop extracts against hydrogen peroxide- or β-amyloid-induced damage in human neuronal SH-SY5Y cells

“…Forty gram of crop mixture (containing embryo rice and wheat germ in a weight ratio of 6:4) and equal amount of water were added into a jar (diameter 6.5 cm × height 12.5 cm), which was then sterilized at 121 °C for 15 min to prepare the crop medium. At the same time, G. lucidum BCRC 36123 was cultured on Gano medium agar plate at 30 °C for 7 days, and then, 5 mL sterile water was added to wash the spores of G. lucidum [19]. This spore suspension was inoculated into the crop medium in the jar to have initial spore density of 10 5 spores/g.…”

Ganoderma adspersum (Ganodermataceae): Investigation of Its Secondary Metabolites and the Antioxidant, Antimicrobial, and Cytotoxic Potential of Its Extracts

“…Today, many products derived from Ganoderma are consumed in the form of powders, food supplements, and teas [17]. Several reports elucidate the antioxidant, anti-inflammatory, anti-hyperlipidemic, anticancer, anti-aging, antimicrobial, antiviral, hepatoprotective, neuroprotective, and antidepressant properties of various Ganoderma species extracts from different parts of the mushroom, both in vitro and in vivo [7,[18][19][20][21][22][23][24][25][26][27].…”