<i>Garcinia kola</i>seed ameliorates renal, hepatic, and testicular oxidative damage in streptozotocin-induced diabetic rats

Adedara, Isaac A.; Awogbindin, Ifeoluwa O.; Anamelechi, Joy Perpetual; Farombi, Ebenezer O.

doi:10.3109/13880209.2014.937504

Cited by 54 publications

(37 citation statements)

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“…The reduction in testicular weight observed in this study is a pointer to codeine-induced alteration in metabolic process that could be associated with excessive tissue break down [40,41]. Studies have reported the possibility of assessing organ toxicity by the organ weight [42,43].…”

Section: Discussionmentioning

confidence: 89%

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO and caspase 3

Akhigbe

Ajayi

2019

Preprint

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Background: Codeine, a 3-methylmorphine, and other related opioids have been implicated in androgen suppression, although the associated mechanisms remain unclear.Aim: Therefore, the objective of the current study was to elucidate the in vivo molecular mechanisms underlying codeine-induced androgen suppression.Methods: This study made use of Twenty-one healthy male rabbits, distributed into three groups randomly, control and codeine-treated groups. The control had 1ml of normal saline daily p.o.The codeine-treated groups received either 4mg/kg b.w of codeine or 10mg/kg b.w of codeine p.o. for six weeks. Reproductive hormonal profile, testicular weight, enzymes, oxidative and inflammatory parameters, histological examination and apoptosis marker were evaluated to examine the effects of codeine use.Key findings: Oral administration of codeine resulted in testicular atrophy and alterations in testicular histomorphology, elevated testicular enzymes, and suppression of circulatory and intratesticular testosterone. These changes were associated with a marked rise in oxidative markers, including oxidative DNA damage, inflammatory response, and caspase-dependent apoptosis.Significance: In conclusion, chronic codeine use resulted in testicular degeneration and testosterone suppression, which may be attributable to nitric oxide-/oxidativestress-mediated caspase-dependent apoptotic testicular cell death.

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Section: Discussionmentioning

confidence: 89%

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO and caspase 3

Akhigbe

Ajayi

2019

Preprint

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“…Male reproductive function is a targeted physiological process mostly damaged by diabetes [18] due to the high susceptibility of testicular microenvironment to oxidative stress. The commonest of non-lethal complications in diabetic men is infertility.…”

Section: Introductionmentioning

confidence: 99%

Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role ofLoranthus micranthus

Ebokaiwe

Ijomone

Osawe³

et al. 2018

Redox Report

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Objectives: Loranthus micranthus is widely used in Nigerian folklore treatment of male infertility and diabetes complications. We investigated this claim in rats rendered diabetic by streptozotocin (STZ). Methods: Induction of diabetes mellitus in adult male Wistar rats was by intraperitoneal injection of STZ (60 mg/kg). The diabetic rats were thereafter treated orally once/day with 5 mg/kg Gilbenclamide or L. micranthus (100 mg/kg or 200 mg/kg) and monitored for 14 days. Clinical observations, hormonal profile, oxidative stress parameters, glucose metabolism enzymes, histopathological examination, apoptotic marker immunoreactivity and western blotting in testes and sperm parameters were evaluated to examine effects of L. micranthus on STZ-diabetic rats. Results: L. micranthus treatment significantly reduced the blood glucose level (45.9% and 84.7% on the 7th and 14th post-treatment days, respectively); increased antioxidant status, improved microarchitecture of testes, reduced lipid peroxidation and increased BCl-2 protein expression in diabetic rats relative to control. Furthermore, treatment with L. micranthus increased steroidogenic enzymes activities, levels of steroid hormones and improved sperm quality, relative to control. Conclusion: The anti-diabetic and aphrodisiac properties exhibited by L. micranthus could be contingent on its ability to restore a balance to the compromised redox status that characterizes male reproductive dysfunction in diabetes.

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“…Seed administration significantly ameliorates hyperglycemia-mediated damage by decreasing the blood glucose level, enhancing the antioxidant system, inhibiting lipid peroxidation, and improving the architecture of the kidney, liver, and testes in STZ-induced diabetic rats (Adedara et al, 2014). Seed administration significantly ameliorates hyperglycemia-mediated damage by decreasing the blood glucose level, enhancing the antioxidant system, inhibiting lipid peroxidation, and improving the architecture of the kidney, liver, and testes in STZ-induced diabetic rats (Adedara et al, 2014).…”

Section: Bitter Kolamentioning

confidence: 99%

“…The extracts of the seed, commonly known as "bitter kola" (Figure 28.6), have been used in African herbal medicine for the treatment of illnesses such as laryngitis, liver diseases, cough, hoarseness of voice, and diabetes and its associated complications (Adedara et al, 2014;Akinmoladun et al, 2015). The extracts of the seed, commonly known as "bitter kola" (Figure 28.6), have been used in African herbal medicine for the treatment of illnesses such as laryngitis, liver diseases, cough, hoarseness of voice, and diabetes and its associated complications (Adedara et al, 2014;Akinmoladun et al, 2015).…”

Section: Bitter Kolamentioning

confidence: 99%

Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals

Duarte¹,

Rolo²,

Palmeira³

2016

Nutraceuticals

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Garcinia kolaseed ameliorates renal, hepatic, and testicular oxidative damage in streptozotocin-induced diabetic rats

Abstract: The findings from this investigation provide persuasive scientific support for the traditional use of G. kola seed in the treatment of diabetes and its associated complications.

Cited by 54 publications

References 46 publications

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO and caspase 3

Testicular toxicity following chronic codeine administration is via oxidative DNA damage and up-regulation of NO and caspase 3

Alteration in sperm characteristics, endocrine balance and redox status in rats rendered diabetic by streptozotocin treatment: attenuating role ofLoranthus micranthus

Mitochondria as a Target for Safety and Toxicity Evaluation of Nutraceuticals

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