Gem‐Difluorination of Triazole Alkyl Functionalized Amino Pyrazoles by Selectfluor to Access 4,4‐Difluoro‐pyrazol‐3‐ones/Pyrazol‐3‐imines

Abstract

We have successfully accomplished gem‐difluorination of triazole alkyl functionalized amino pyrazoles in the presence of Selectfluor under dry condition and obtained 4,4‐difluoro pyrazol‐3‐imines derivatives in high yield. However, in the presence of water, 4,4‐difluoro pyrazol‐3‐one derivatives were afforded.

Synthesis of Highly Substituted Fluoro Chromenones in a “One‐Pot Four‐ Component Strategy” Using NFSI as a Fluorinating Reagent

“…In continuation of our efforts to develop the novel fluorination methodologies, we chose a multicomponent strategy to synthesize fluorine substituted chromenones, as multicomponent reactions (MCRs) have the additional advantage of rapid synthesis with high selectivity for complex molecules. Recently, we reported the synthesis of non‐fluorinated chromenone derivatives from β ‐arylthioacetanilide using InCl 3 as a catalyst .…”