<i>Gentianella acuta</i> mitigates cardiovascular damage and inflammation in diet‑induced hypercholesterolaemic rats

Si, Mingdong; Wu, Meng; Huo, Yingying; Li, Aiying; Guan, Shengjiang; Ma, Donglai; Ma, Zhihong

doi:10.3892/etm.2021.10694

Cited by 6 publications

(3 citation statements)

References 38 publications

(42 reference statements)

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“…The mortality, incidence, and prevalence rates of CVD continue to increase globally. 31 Obesity directly contributes to the development of CVD. 32 BMI was consistently positively associated with CVD.…”

Section: Discussionmentioning

confidence: 99%

Cardiovascular disease risk perceptions and influencing factors among Chinese systemic lupus erythematosus patients

Zhang,

Yu,

Zhao

et al. 2023

Lupus

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Background Systemic Lupus Erythematosus patients (SLE) are at a higher risk of cardiovascular events than the general population. This study aimed to investigate the risk perception of cardiovascular disease (CVD) and to analyze its influence factors among Chinese SLE patients. Methods This was a cross-sectional study. Convenience sampling was used to select 201 patients with SLE who had attended the outpatient and inpatient departments of the Department of Rheumatology and Immunology at the First Affiliated Hospital of the University of Science and Technology of China from November 2022 to March 2023. The following were used in the study: the Chinese version of the Attitudes and Beliefs about Cardiovascular Disease Risk Questionnaire, the Social Support Rating Scale, the Connor–Davidson Resilience Scale, the General Self-Efficacy Scale, the Hospital Anxiety and Depression Scale, the Health Literacy Management Scale, and sociodemographic and disease-related data. Results The mean (standard deviation) risk perception score of CVD patients with SLE was 57.18 ± 13.02. A Pearson correlation analysis showed that CVD risk perceptions were positively correlated with health literacy ( r = 0.152, p < .05) and depression ( r = 0.277, p < .05), and negatively correlated with social support ( r = −0.393, p < .05) and psychological resilience ( r = −0.374, p < .05). A multiple linear regression analysis showed that body mass index (BMI), family history, health literacy, depression, social support, and psychological resilience were the main factors influencing CVD risk perceptions among Chinese SLE patients ( p < .05). Conclusions Body mass index, family history, health literacy, depression, social support, and psychological resilience influenced CVD risk perceptions among Chinese SLE patients. Healthcare workers should objectively and accurately assess the levels of CVD risk perception among SLE patients, identify the risk factors of CVD, adopt effective health risk communication strategies to help patients develop appropriate risk perceptions, and raise risk awareness to adopt active coping approaches to reduce risk.

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Section: Discussionmentioning

confidence: 99%

Cardiovascular disease risk perceptions and influencing factors among Chinese systemic lupus erythematosus patients

Zhang,

Yu,

Zhao

et al. 2023

Lupus

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“…We followed the method of Si et al. ( 2021 ) for which 32 specific pathogen-free male Sprague Dawley rats weighing 160–180 g were purchased from Beijing Vital River Laboratory Animal Technology Co., Ltd. and were adaptively fed at room temperature for 1 week. Rats were randomized into four groups, each containing eight rats: (1) normal diet (Control), (2) normal diet + S. mussotii (Control-S), (3) high-fat diet (Model), and (4) high-fat diet + S. mussotii (Model-S).…”

Section: Methodsmentioning

confidence: 99%

Swertia mussotii prevents high-fat diet-induced non-alcoholic fatty liver disease in rats by inhibiting expression the TLR4/MyD88 and the phosphorylation of NF-κB

Dong

Cheng

et al. 2022

Pharmaceutical Biology

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Context Swertia mussotii Franch. (Gentianaceae) is a source of the traditional Tibetan medicine, ZangYinChen, and is used to treat chronic hepatitis and many types of jaundice. Objective This study explored the therapeutic effects and mechanism of S. mussotii on non-alcoholic fatty liver disease in diet-induced hypercholesterolaemia. Materials and methods After a week of adaptive feeding, 32 Sprague-Dawley rats were divided into four groups: (1) Control, (2) Control-S, (3) Model, and (4) Model-S. During the 12 experimental weeks, we established the Model using a high-fat diet. Control-S and Model-S were given 1.0 g/kg S. mussotii water extract via gavage starting in the fifth week until the end of experiment. Results When compared with Model rats, the S. mussotii water extract led to a reduction in high-density lipoproteins (43.9%) and albumin (13.9%) and a decrease in total cholesterol (54.0%), triglyceride (45.6%), low-density lipoproteins (8.6%), aspartate aminotransferase (11.0%), alanine aminotransferase (15.5%), alkaline phosphatase (19.1%), total protein (6.4%), and glucose (20.8%) in serum. A reduction in three cytokines (IL-1β, IL-6, and TNFα) was detected. Histopathological examination showed that liver steatosis was significantly relieved in S. mussotii -treated high-fat diet rats. S. mussotii also caused a downregulation in the expression of TLR4 (43.2%), MyD88 (33.3%), and a decrease in phosphorylation of NF-κB. Discussion and conclusions Our findings indicate that S. mussotii may act as a potential anti-inflammation drug via inhibition of the TLR4/MyD88/NF-κB pathway. Further in vivo and in vitro studies are needed to validate its potential in clinical medicine.

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“…Gentianella acuta ( G. acuta ) is a herb of the Gentianaceae family that exhibits many pharmacological activities, such as reducing pain and inflammation, and shows antineoplastic activity [ 18 – 20 ]. Moreover, G. acuta , known as “Wenxincao” in Mongolia, China, is generally used to treat heart disease [ 21 ].…”

Section: Introductionmentioning

confidence: 99%

Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4

et al. 2023

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To date, there is no effective therapy for pathological cardiac hypertrophy, which can ultimately lead to heart failure. Bellidifolin (BEL) is an active xanthone component of Gentianella acuta (G. acuta) with a protective function for the heart. However, the role and mechanism of BEL action in cardiac hypertrophy remain unknown. In this study, the mouse model of cardiac hypertrophy was established by isoprenaline (ISO) induction with or without BEL treatment. The results showed that BEL alleviated cardiac dysfunction and pathological changes induced by ISO in the mice. The expression of cardiac hypertrophy marker genes, including ANP, BNP, and β-MHC, were inhibited by BEL both in mice and in H9C2 cells. Furthermore, BEL repressed the epigenetic regulator bromodomain-containing protein 4 (BRD4) to reduce the ISO-induced acetylation of H3K122 and phosphorylation of RNA Pol II. The Nox4/ROS/ADAM17 signalling pathway was also inhibited by BEL in a BRD4 dependent manner. Thus, BEL alleviated cardiac hypertrophy and cardiac dysfunction via the BRD4/Nox4/ROS axes during ISO-induced cardiac hypertrophy. These findings clarify the function and molecular mechanism of BEL action in the therapeutic intervention of cardiac hypertrophy.

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Gentianella acuta mitigates cardiovascular damage and inflammation in diet‑induced hypercholesterolaemic rats

Cited by 6 publications

References 38 publications

Cardiovascular disease risk perceptions and influencing factors among Chinese systemic lupus erythematosus patients

Cardiovascular disease risk perceptions and influencing factors among Chinese systemic lupus erythematosus patients

Swertia mussotii prevents high-fat diet-induced non-alcoholic fatty liver disease in rats by inhibiting expression the TLR4/MyD88 and the phosphorylation of NF-κB

Bellidifolin ameliorates isoprenaline-induced cardiac hypertrophy by the Nox4/ROS signalling pathway through inhibiting BRD4

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