Ginkgo biloba extract mitigates the neurotoxicity of AlCl ₃ in alzheimer rat’s model: role of apolipoprotein E4 and clusterin genes in stimulating ROS generation and apoptosis

Effect of Ginkgo Biloba Extract (EGb761) on Cerebral Nervous System in Patients with ALzheimer’s Disease

“…However, before this conjecture appeared, the therapeutic research of AChE inhibitors on ad has been widely studied since the introduction of the first cholinesterase inhibitor (ChEI) in 1997 [16]. At present, the International Pharmaceutical Association has approved the use of AChE inhibitors to treat mild to moderate AD symptoms, such as kabbalatine and donepezil [18]. In recent years, in order to reduce side effects and improve drug effects, people have tried to find a plant that can extract natural compounds to produce AChE inhibitors [18].…”

“…At present, the International Pharmaceutical Association has approved the use of AChE inhibitors to treat mild to moderate AD symptoms, such as kabbalatine and donepezil [18]. In recent years, in order to reduce side effects and improve drug effects, people have tried to find a plant that can extract natural compounds to produce AChE inhibitors [18]. In 2018, Zhang et al selected 21 EGb761 compounds and established a kinetic simulation model through molecular docking experiments to identify the ability of 21 compounds to bind to ache.…”