<i>Grifola frondosa</i>polysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats

Li, Lü; Guo, Weiling; Zhang, Wen; Xu, Jiaxin; Qian, Min; Bai, Weidong; Zhang, Yanyan; Rao, Pingfan; Ni, Li; Lv, Xu-Cong

doi:10.1039/c9fo00075e

Cited by 156 publications

(77 citation statements)

References 52 publications

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“…Lipid drops are usually accumulated in liver tissue, causing hepatic structural disruption and dysfunction, which ultimately leads to liver hypertrophy and fatty liver disease [21]. Therefore, controlling lipid accumulation in the liver can prevent the progression of lipid metabolic disorders [22]. In this study, fatty liver disease was mimicked in broilers by consecutive injection of CORT, showing with the typical characteristics of fatty liver disease as the previous report [10].…”

Section: Discussionsupporting

confidence: 64%

“…A study have shown that more abundance of Proteobacteria was found in fecal of children who were high-fat, and low-ber consumers [38]. Notably, Intestinimonas, a short-chain fatty acids (SCFA) -producing intestinal bacterium [22], was enriched in the CORT&PB group. It has been reported that SCFA is generally considered to have many important effects on maintaining host health such as providing nutrients and energies for the host [39], and reduced production of SCFA is a crucial pathogenic cause in fatty liver disease [40].…”

Section: Discussionmentioning

confidence: 98%

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Probiotics Supplementation Alleviate Corticosterone-induced Fatty Liver Disease Related With the Changes of Hepatic Lipogenesis and Gut Microbiota Profile in Broiler

Mei

Feng

Yao

et al. 2020

Preprint

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Background:Emerging evidencesindicate a close relationship between gut microbiotaand fatty liver disease.It has been suggested that gut microbiota modulation with probiotics improved fatty liver disease in rodents and human, yet it still remains unclear in poultry.Results: Ninety six one-day-old green-legged chicken were divided into control group (CON) and probiotic group (PB), respectively. Probiotics were administrated throughdrinking water for two weeks from 1-day-old. At 28 d of age,16 broilers selectedfromCON or PB group randomly, and receivedvehicle(15% ethanol) or CORT(4.0 mg/kg)treatmentdaily viasubcutaneous injection for a week to induce fatty liver. At the end of the experiment, broilers from 4 groups,control group(CON), corticosterone group (CORT), probiotic group (PB), PB plusCORT group(CORT&PB),were slaughtered for sampling and analysis.The results showed that probiotics administration significantly prevented CORT-induced body weight loss(P<0.05), but did not alleviate the reduction of immune organs weight caused by CORT. Compared to CON,broilers in CORT group exhibited a significant increase of triglyceride (TG) levelin both plasma and liver(P< 0.01), as well as severe hepatocytic steatosis and hepatocellular ballooning, and accompanied with the up-regulation of hepatic lipogenesis genes expression. However, probiotics supplementation markedly decreased the intrahepatic lipid accumulation and steatosis histological score, which was associated withthedown-regulation of sterol regulatory element-binding protein-1 (SREBP1) and acetyl-CoA carboxylase (ACC) mRNA (P< 0.05)as well as it protein (P= 0.06) expression.Cecal microbiota composition was determined by 16S rRNA high-throughput sequencing. Results showed that CORT treatment induced distinct gut microbiota alterations with a decrease of microbial diversity, and anincrease of proteobacteriaabundance (P<0.05). On the contrary, probiotic supplementation increased the beta diversity and increased community richness and diversity index(P> 0.05), as well as the abundance of Intestinimonas(P<0.05).Conclusion: Our results indicate that CORT treatment induced serious fatty liver disease and altered the gut microbiota composition in broilers, however,probiotics supplementation from post-hatching had a beneficial effect on alleviatingfatty liver disease through regulating lipogenic genes expression and increasing gut microbiota diversity andbeneficial bacteria abundanceimbalance.

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Section: Discussionsupporting

confidence: 64%

Section: Discussionmentioning

confidence: 98%

Probiotics Supplementation Alleviate Corticosterone-induced Fatty Liver Disease Related With the Changes of Hepatic Lipogenesis and Gut Microbiota Profile in Broiler

Mei

Feng

Yao

et al. 2020

Preprint

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“…Furthermore, the same study demonstrated changes in farnesoid X receptor (FXR)-dependent gene expression, including increases in Cyp7a1, suggesting enhanced bile acid synthesis [10]. Mushroom polysaccharide supplementation of a high fat diet led to similar changes in gene expression, along with increases in Parasutterella that were correlated with reductions in serum lipids [24]. While total cholesterol levels were decreased, although not signi cantly, by the introduction of Parasutterella, LDL levels were not measured [10], suggesting that the mechanisms documented in mice could be acting similarly in humans consuming RPS, speci cally those with above-threshold levels of Parasutterella.…”

Section: Discussionmentioning

confidence: 83%

Increasing levels of Parasutterella in the gut microbiome correlate with improving Low-Density Lipoprotein levels in healthy adults consuming resistant potato starch during a randomised trial

Bush

Alfa

2020

Preprint

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Background Prebiotics, defined as a substrate that is selectively utilized by host microorganisms conferring a health benefit, present a potential option to optimize gut microbiome health. Elucidating the relationship between specific intestinal bacteria, prebiotic intake, and the health of the host remains a primary microbiome research goal. Objective To assess the correlations between gut microbiota, serum health parameters, and prebiotic consumption in healthy adults. Methods We performed ad hoc exploratory analysis of changes in abundance of genera in the gut microbiome of 75 participants from a randomized, placebo-controlled clinical trial that evaluated the effects of resistant potato starch (RPS; MSPrebiotic®, N = 38) intervention versus a fully digestible placebo (N = 37) for which primary and secondary outcomes have previously been published. Pearson correlation analysis was used to identify relationships between health parameters (ie. blood glucose and lipids) and populations of gut bacteria. Results Abundance of Parasutterella (phylum Proteobacteria) tended to increase in the gut microbiome of individuals consuming RPS and those increases in Parasutterella were correlated with reductions in low-density lipoprotein (LDL) levels in participants consuming RPS but not placebo. Segregating RPS-consuming individuals whose LDL levels decreased (ie “Responders”) from those who did not (ie. “Non-Responders”) revealed that LDL Responders had significantly higher levels of Parasutterella both at baseline and after 12 weeks of consuming RPS. Conclusion Our analyses suggest that RPS may help improve LDL levels depending upon the levels of Parasutterella in an individual’s gut microbiome. Trial Registration: This study protocol was reviewed and approved by Health Canada (Submission #188517; “Notice of Authorization” dated 06/05/13) and registered as NCT01977183 (10/11/13) listed on NIH website: ClinicalTrials.gov. Data generated in this study have been submitted to NCBI (http://www.ncbi.nlm.nih.gov/bioproject/381931).

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“…52 As a member of the Barnesiellaceae family, Barnesiella is also a SCFA producer. 53 It has recently been reported that multiple bioactive components, such as mannoligosaccharides (MOS) from spent coffee grounds, 54 polyphenolrich cranberry extracts, 55 Grifola frondosa polysaccharides, 56 polyunsaturated fatty acids from Spirulina platensis, 57 and decaffeinated green and black tea polyphenols, 58 might regulate glucose homeostasis, insulin sensitivity and lipid metabolism as well as modulate body weight through modifying gut microbiota, including increasing the abundance of Barnesiella. Moreover, improving T2DM with a traditional Chinese medicine, Xiexin Tang, was also associated with enriched Barnesiella.…”

Section: Discussionmentioning

confidence: 99%

Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring

et al. 2019

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Grifola frondosapolysaccharides ameliorate lipid metabolic disorders and gut microbiota dysbiosis in high-fat diet fed rats

Abstract: G. frondosa polysaccharides have the potential to ameliorate lipid metabolic disorders in part through modulating gut microbiota and mRNA expression of genes involved in hepatic lipid and cholesterol metabolism.

Cited by 156 publications

References 52 publications

Probiotics Supplementation Alleviate Corticosterone-induced Fatty Liver Disease Related With the Changes of Hepatic Lipogenesis and Gut Microbiota Profile in Broiler

Probiotics Supplementation Alleviate Corticosterone-induced Fatty Liver Disease Related With the Changes of Hepatic Lipogenesis and Gut Microbiota Profile in Broiler

Increasing levels of Parasutterella in the gut microbiome correlate with improving Low-Density Lipoprotein levels in healthy adults consuming resistant potato starch during a randomised trial

Gut microbiota might be a crucial factor in deciphering the metabolic benefits of perinatal genistein consumption in dams and adult female offspring

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