<i>H. pylori cagL</i> amino acid sequence polymorphism Y58E59 induces a corpus shift of gastric integrin α5β1 related with gastric carcinogenesis

Yeh, Yi Chun; Chang, Wei; Yang, Hsiao Bai; Cheng, Hsiu Chi; Wu, Jiunn Jung; Sheu, Bor Shyang

doi:10.1002/mc.20753

Cited by 45 publications

(100 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…A study on 61 isolates from patients with digestive disease in Iran, showed that 96.7% were cagL positive. This report was concordant with the results from Taiwan, where the 98.6% of the patients were cagL positive, but no remarkable association was detected between the cagL genotype and clinical outcomes (P>0.05) (Kwok et al, 2007;Yeh et al, 2011;Wang et al, 2013;Yadegar et al, 2014). These results are consistent with our results in GC group but not in PU group, while the cagL genotype is remarkably and independently associated with the risk of PU in Iran (P=0.021), but no association was found with the risk of GC (P>0.05).…”

Section: Discussionsupporting

confidence: 90%

“…Recently, it has been demonstrated that 86.6% of the H. pylori isolates from Indian patients were cagL positive. Other studies in Malaysia, Singapore, and Taiwan demonstrated that more than 85% of the isolates were cagL positive (Schmidt et al, 2010;Yeh et al, 2011). A study on 61 isolates from patients with digestive disease in Iran, showed that 96.7% were cagL positive.…”

Section: Discussionmentioning

confidence: 95%

“…H. pylori has several virulence factors that might take part in mucosal damage (Mahdavi et al, 2002;Erzin et al, 2006;Kusters et al, 2006;Miernyk et al, 2011;Yeh et al, 2011;Shiota et al, 2012). This study investigated the relevance of various virulence factors (cagH, cagL, cagG, and orf17) and their relationship with sever gastrointestinal disease.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Helicobacter pylori cag Pathogenicity Island cagL and orf17 Genotypes Predict Risk of Peptic Ulcerations but not Gastric Cancer in Iran

Raei¹,

Latifi‐Navid²,

Zahri³

2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Gastric cancer (GC) is the third most common cancer regarding mortality in the world. The cag pathogenicity island (PAI) of Helicobacter pylori which contains genes associated with a more aggressive phenotype may involve in the pathogenesis of gastrointestinal disease. We here aimed to examine the associations of cagH, cagL, orf17, and cagG genotypes of H. pylori cag PAI with severe gastrointestinal disease. Materials and Methods: A total of 242 H. pylori strains were genotyped. Histopathological examination and classification of subjects were performed. Results: The frequencies of the cagH, cagL, cagG, and orf17 genotypes were 40/54 (74.1%), 53/54 (98.1%), 38/54 (70.4%), and 43/54 (79.6%), respectively, in patients with peptidic ulceration (PU),while in the control group, the frequencies were 87/147 (59.6%) for cagH, 121/146 (82.9%) for cagL, 109/146 (74.7%) for cagG, and 89/146 (61.0%) for orf17. The results of simple logistic regression analysis showed that the cagL and orf17 genotypes were significantly associated with an increased risk of PU not GC; the ORs (95% CI) were 10.950 (1.446-82.935), and 2.504 (1.193-5.253), respectively. No significant association was found between the cagH and cagG genotypes and the risk of both the PU and the GC in Iran (P>0.05). Finally, multiple logistic regression analysis showed that the cagL genotype was independently and significantly associated with the ageand sex-adjusted risk for PU; the OR (95% CI) was 9.557 (1.219-17.185). Conclusions: We conclude that the orf17 and especially cagL genotypes of H. pylori cag PAI could be factors for risk prediction of PU, but not GC in Iran.

show abstract

Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 95%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Helicobacter pylori cag Pathogenicity Island cagL and orf17 Genotypes Predict Risk of Peptic Ulcerations but not Gastric Cancer in Iran

Raei¹,

Latifi‐Navid²,

Zahri³

2015

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…The present study indicated 86.6 % of our isolates were cagL positive and all carried the RGD motif in their amino acid sequences. Studies from Malaysia, Singapore, and Taiwan reported [85 % prevalence of cagL in their H. pylori isolates, and the results are concordant with the current finding [15,16]. Moreover, the presence of RGD motif in all the current isolates suggests that the CagA translocation is mediated through an RGD-dependent pathway.…”

Section: Discussionsupporting

confidence: 84%

“…Therefore, it is rational to check whether the cagL amino acid sequence polymorphisms correlate with clinical disease. Previously, a study from Taiwan reported a higher rate of the amino acid sequence polymorphisms Y58 and E59 in GC patients (P \ 0.05) and concluded that cagL-Y58E59 isolates possibly exert stronger acid suppression during chronic infection [16]. On the other hand, the results of Saha et al [17] help in part to explain that CagL may dissociate ADAM17 of integrin a5b1 to contribute to hypochlorhydria during H. pylori infection.…”

Section: Discussionmentioning

confidence: 95%

Helicobacter pylori cagL amino acid polymorphisms and its association with gastroduodenal diseases

et al. 2012

View full text Add to dashboard Cite

CagL is a pilus protein of Helicobacter pylori that interacts with host cellular a5b1 integrins through its arginine-glycine-aspartate (RGD) motif, guiding proper positioning of the T4SS and translocation of CagA. Deletion or sequence variations of cagL significantly diminished the ability of H. pylori to induce secretion of IL-8 by the host cell. Therefore, this study was undertaken to investigate the association of cagL and its amino acid sequence polymorphisms with gastric cancer (GC), peptic ulcer disease (PUD), and non-ulcer dyspepsia (NUD) as there are no such studies from India. In total, 200 adult patients (NUD 120, PUD 30, GC 50) who underwent an upper gastrointestinal endoscopy were enrolled. H. pylori infection was diagnosed by rapid urease test, culture, histopathology, and PCR. The collected isolates were screened for cagL genotype by PCR and assessed for amino acid sequence polymorphisms using sequence translation. The prevalence of H. pylori infection in study population was 52.5 %. Most of the isolates were cagL genopositive (86.6 %), and all had RGD motif in their amino acid sequences. D58 and K59 polymorphisms in cagLgenopositive strains were significantly higher in GC patients (P \ 0.05). Combined D58K59 polymorphism was associated with higher risk of GC (3.8-fold) when compared to NUD. In conclusion, H. pylori cagL amino acid polymorphisms such as D58K59 are correlated with a higher risk of GC in the Indian population. Further studies are required to know the exact role of particular cagL amino acid polymorphisms in the pathogenicity of H. pylori infection.

show abstract

Pathogenesis of Helicobacter pylori in Humans

Zambon

Basso

Pelloso

et al. 2015

Human Emerging and Re‐emerging Infections

View full text Add to dashboard Cite

The Old World arenaviruses: taxonomic and zoonotic introduction Arenaviruses represent a fast-growing group of rodent-borne viruses (see Notes in the Proofs) which are an example of how environmental changes disrupt the natural animal virus-host balance and result in unexpected diseases. In the wild, arenaviruses exist as chronic infections in specific rodent hosts. This provides ideal conditions for competition within viral quasispecies for improved adaptation to the host. Analysis of arenavirus phylogeny and rodent cytochrome-b sequences provides examples of coevolution of arenaviruses with their rodent hosts. Based on their antigenic properties and geographic distribution approximately two dozen arenaviruses discovered so far are placed into two groups: the Old World (OW) or Lassa-LCMV complex and the New World (NW) or Tacaribe complex (Salvato et al., 2012). In general, the OW viruses are hosted by rodents of the family Muridae, subfamily Murinae. The NW arenaviruses are associated with rodents of the subfamily Sigmodontinae which are divided into the North and South American lineages. Phylogenetically the NW arenaviruses are further divided into clades A, B, C, and a recombinant A/B clade. Lymphocytic choriomeningitis virus (LCMV), the prototypic arenavirus that belongs to the OW group, is hosted by the house mouse (Mus musculus). The virus is distributed worldwide and can cause aseptic meningitis or meningoencephalitis in immunocompetent children and adults. Recent studies indicate that LCMV is also an under-recognized cause of congenital infection and neurological disease in the fetus and newborns (Bonthius, 2012; Laposova

show abstract

H. pylori cagL amino acid sequence polymorphism Y58E59 induces a corpus shift of gastric integrin α5β1 related with gastric carcinogenesis

Cited by 45 publications

References 22 publications

Helicobacter pylori cag Pathogenicity Island cagL and orf17 Genotypes Predict Risk of Peptic Ulcerations but not Gastric Cancer in Iran

Helicobacter pylori cag Pathogenicity Island cagL and orf17 Genotypes Predict Risk of Peptic Ulcerations but not Gastric Cancer in Iran

Helicobacter pylori cagL amino acid polymorphisms and its association with gastroduodenal diseases

Pathogenesis of Helicobacter pylori in Humans

Contact Info

Product

Resources

About