<i>Helicobacter cinaedi</i>Infection of Abdominal Aortic Aneurysm, Japan

Kakuta, Risako; Yano, Hisakazu; Kanamori, Hajime; Shimizu, Takuya; Gu, Yoshiaki; Hatta, Mochammad; Aoyagi, Tetsuji; Endo, Shiro; Inomata, Shinji; Oe, Chihiro; Tokuda, Koichi; Ozawa, Daiki; Gotō, Hitoshi; Katori, Yukio; Kaku, Mitsuo

doi:10.3201/eid2011.140440

Cited by 25 publications

(23 citation statements)

References 10 publications

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“…Third, culture was positive in all of the previous patients, while it was negative in this case, although this may have been related to prior antimicrobial therapy. We previously reported that 16S rRNA gene analysis was useful in patients with culture negative infection [7], and we employed this technique to identify the microorganism in the middle ear fluid of this patient. Although 7/8 cases, including this patient, responded to surgery and/or antimicrobial therapy, it is noteworthy that one patient died of ruptured intracranial mycotic aneurysm.…”

Section: Discussionmentioning

confidence: 99%

“…To identify the causative organism, 16S ribosomal RNA (16S rRNA) gene sequencing was performed. Bacterial DNA was extracted from middle ear fluid using the QIAamp DNA Minikit (Qiagen, Hilden, Germany), after which polymerase chain reaction (PCR) amplification and 16S rRNA gene sequencing were performed as described previously [7]. We used the EzTaxon-e Database for sequence analysis (http://eztaxon-e.ezbiocloud.net/).…”

Section: S Ribosomal Rna Gene Sequencing and Bacterial Studiesmentioning

confidence: 99%

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First report of severe acute otitis media caused by Campylobacter rectus and review of the literature

Kakuta

Hidaka

Yano

et al. 2016

Journal of Infection and Chemotherapy

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Section: Discussionmentioning

confidence: 99%

Section: S Ribosomal Rna Gene Sequencing and Bacterial Studiesmentioning

confidence: 99%

First report of severe acute otitis media caused by Campylobacter rectus and review of the literature

Kakuta

Hidaka

Yano

et al. 2016

Journal of Infection and Chemotherapy

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“…Helicobacter cinaedi often causes enteritis and bacteraemia, and sometimes causes cellulitis and arthritis . In rare cases it causes meningitis, infective endocarditis, infected aortic aneurysm, myopericarditis and pyoderma gangrenosum‐like ulcer . Most patients are immunocompromised, having HIV infection, haematological diseases, renal failure or a current history of anticancer chemotherapy.…”

Section: Clinical Features and Characteristic Skin Manifestations Of mentioning

confidence: 99%

Cutaneous manifestations ofHelicobacter cinaedi: a review

Shimizu

2016

Br J Dermatol

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Helicobacter cinaedi is an emerging Gram-negative spiral bacillus that was first reported in 1984. It has been implicated as a cause of gastroenteritis and bacteraemia in immunocompromised individuals. Helicobacter cinaedi-associated bacteraemia is sometimes accompanied by skin lesions; however, the cutaneous manifestations of this pathogen are not widely known. To our knowledge, a comprehensive review with detailed analysis of skin lesions associated with H. cinaedi has not been conducted. This article summarizes the clinical appearance of H. cinaedi cellulitis and its management. In addition, we conducted a retrospective review of 73 patients with H. cinaedi bacteraemia at a single institution, to further clarify the characteristic cutaneous features. It was found that 30% (22/73) of the cases of H. cinaedi bacteraemia had sudden-onset erythema accompanied by high fever. The most common cutaneous symptom of H. cinaedi bacteraemia was found to be mild cellulitis, appearing as multiple painful infiltrated erythemas on the extremities. As H. cinaedi is not always detectable in routine blood culture techniques, evaluation of these characteristic cutaneous manifestations seems important in diagnosis. Helicobacter cinaedi infection should be added to the diagnostic list of unspecified fever with painful infiltrated erythemas.

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“…Subsequently, Hc was cultured from surgically removed aneurysms characterized by severe atherosclerosis and inflammation23 and bacterial antigens were found in macrophages of atherosclerotic aortic tissues25. The bacterium was shown to trigger the differentiation of monocytes into macrophages releasing pro-inflammatory cytokines and to cause the formation of foam cells26.…”

Section: Discussionmentioning

confidence: 99%

“…The bacterium efficiently translocates from the intestinal tract, the primary site of infection, to the vascular system, where it can cause endovascular infections20. Cases of endocarditis21, myopericarditis22 and aneurysms2324 have been attributed to Hc infection, and Hc antigens have been found inside macrophages in both mature and immature human atheromas25. The etiological role of Hc has been further substantiated by the finding that Hc infection worsens the atherosclerotic lesions in hyperlipidaemic mice26.…”

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confidence: 99%

The Helicobacter cinaedi antigen CAIP participates in atherosclerotic inflammation by promoting the differentiation of macrophages in foam cells

D’Elios

Vallese

Capitani

et al. 2017

Sci Rep

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Recent studies have shown that certain specific microbial infections participate in atherosclerosis by inducing inflammation and immune reactions, but how the pathogens implicated in this pathology trigger the host responses remains unknown. In this study we show that Helicobacter cinaedi (Hc) is a human pathogen linked to atherosclerosis development since at least 27% of sera from atherosclerotic patients specifically recognize a protein of the Hc proteome, that we named Cinaedi Atherosclerosis Inflammatory Protein (CAIP) (n = 71). CAIP appears to be implicated in this pathology because atheromatous plaques isolated from atherosclerotic patients are enriched in CAIP-specific T cells (10%) which, in turn, we show to drive a Th1 inflammation, an immunopathological response typically associated to atherosclerosis. Recombinant CAIP promotes the differentiation and maintenance of the pro-inflammatory profile of human macrophages and triggers the formation of foam cells, which are a hallmark of atherosclerosis. This study identifies CAIP as a relevant factor in atherosclerosis inflammation linked to Hc infection and suggests that preventing and eradicating Hc infection could reduce the incidence of atherosclerosis.

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Helicobacter cinaediInfection of Abdominal Aortic Aneurysm, Japan

Cited by 25 publications

References 10 publications

First report of severe acute otitis media caused by Campylobacter rectus and review of the literature

First report of severe acute otitis media caused by Campylobacter rectus and review of the literature

Cutaneous manifestations ofHelicobacter cinaedi: a review

The Helicobacter cinaedi antigen CAIP participates in atherosclerotic inflammation by promoting the differentiation of macrophages in foam cells

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