<i>Helicobacter</i>species sequences in liver samples from patients with and without hepatocellular carcinoma

Pellicano, Rinaldo; Mazzaferro, Vincenzo; Grigioni, Francesco; Cutufia, Miguel Angel; Fagoonee, Sharmila; Silengo, Lorenzo; Rizzetto, Mario; Ponzetto, Antonio

doi:10.3748/wjg.v10.i4.598

Cited by 95 publications

(75 citation statements)

References 26 publications

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“…There are 10 case-control studies on this association (30)(31)(32)(33)(34)(35)(36)(37)(38)(39). All of them, except one (39), describe a significantly greater presence of EHH DNA in the liver tissue of patients with HCC than in healthy subjects (40).…”

Section: Hepatocarcinomamentioning

confidence: 99%

Enterohepatic Helicobacter other than Helicobacter pylori

Mateos-Muñoz

Pérez-de-la-Serna

Ruiz-de-León

et al. 2013

Rev. esp. enferm. dig.

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The Helicobacter genus includes Gram negative bacteria which were originally considered to belong to the Campylobacter genus. They have been classified in a separate genus since 1989 because they have different biochemical characteristics, with more than 24 species having been identified and more still being studied.H. pylori is the best known. It has an important etiopathogenic role in peptic ulcer disease and gastric cancer. Enterohepatic Helicobacters (EHH) other than H. pylori colonize the bowel, biliary tree and liver of animals and human beings with pathogenic potential. The difficulties existing to correctly isolate these microorganisms limit the description of their true prevalence and of the diseases they cause. Many studies have tried to discover the different clinical implications of EHH. Diseases like chronic liver disease, autoimmune hepatitis, hepatocarcinoma, autoimmune hepatobiliary disease, biliary lithiasis, cholangiocarcinoma and gallbladder cancer, Meckel´s diverticulum, acute appendicitis and inflammatory bowel disease have been related with different EHH species with different results, although their prevalence is greater than in healthy subjects. However, these data are currently not sufficient to draw definitive conclusions. Finally, the best known role of EHH in bowel disease is production of acute and chronic diarrhea pictures initially referred to as Campylobacter. H. pullorum has been identified in patients with acute gastroenteritis. The correct identification of EHH as producers of infectious gastroenteritis is found in its antibiotic susceptibility. It is generally macrolidesusceptible and quinolone-resistant.

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Section: Hepatocarcinomamentioning

confidence: 99%

Enterohepatic Helicobacter other than Helicobacter pylori

Mateos-Muñoz

Pérez-de-la-Serna

Ruiz-de-León

et al. 2013

Rev. esp. enferm. dig.

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“…Fourth, the lack of DNA from other gut organisms in HCC tissues, suggesting that helicobacter DNA detection does not represent non-specific DNA contamination from the portal circulation [13,15]. Finally, the absence or lower frequency of helicobacter in primary versus metastatic liver carcinomas suggests a more specific association with HCC [12,14,16]. Nevertheless, this link between HCC and Helicobacter is tempered by the observations of others that Helicobacter DNA was not detected in a group of 55 liver tissues [21].…”

Section: Discussionmentioning

confidence: 99%

“…To date, the possible association between HCC and helicobacter has been supported by a number of diverse observations which can be summarized as follows. First, based on serological studies as well as direct detection in liver tissues, Helicobacter is more common in those with cirrhosis than non-cirrhosis and, of those with cirrhosis, positive serology is found more frequently in those who have HCC [9][10][11][12][13][14][15][16]19]. Secondly, helicobacter DNA in HCC tissues has been reported from multiple geographic locations.…”

Section: Discussionmentioning

confidence: 99%

“…Since that time, a growing body of literature has suggested a role for Helicobacter in human HCC. Specifically, individuals with HCC are more likely to have serological evidence for past Helicobacter infection [5][6][7][8] and Helicobacter DNA can be found in HCC tissues more commonly than controls [9][10][11][12][13][14][15][16]. In addition to HCC, Helicobacter DNA has also been reported in intrahepatic cholangiocarcinomas [9,12].…”

Section: Introductionmentioning

confidence: 99%

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Low frequency of Helicobacter DNA in benign and malignant liver tissues from Baltimore, United States

Vivekanandan

Torbenson

2008

Human Pathology

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Helicobacter DNA has been reported in hepatocellular carcinoma tissues in several studies from varying geographical locations, raising the possibility that helicobacter infection may contribute to the pathogenesis of hepatocellular carcinoma. Other known risk factors for hepatocellular carcinoma show significant geographical variability, but whether the same holds for helicobacter is unknown. We studied the prevalence of Helicobacter DNA in a United States cohort of HCC, where the prevalence of helicobacter infection is low in the general population. Liver tissues from 57 individuals were examined. Thirty-five individuals had paired tumor/non-tumor samples, including 21 cases of hepatocellular carcinoma, for a total of 92 samples studied. Both Helicobacter genus and Helicobacter pylori species specific PCR was performed. Helicobacter DNA was detected in 5/57 (9%) cases, all in non-neoplastic cirrhotic liver tissues from individuals with hepatitis C infection (N=4) or alcohol liver disease (N=1). Tissues from 22 hepatocellular carcinomas and 10 cholangiocarcinomas were all negative as were tissues from 8 benign primary hepatic tumors. In conclusion, Helicobacter DNA was detectable in 9% of liver tissues in this cohort, but was not found in primary benign or malignant liver tumors. These findings indicate that Helicobacter infection is unlikely to be etiologically associated with hepatocellular carcinoma in this cohort. If Helicobacter infection does contribute to the development of hepatocellular carcinoma in general, then significant regional variability must exist.

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“…Helicobacter pylori (H. pylori) is a gram-negative, spiralshaped, microaerophilic bacterium which can cause gastritis, peptic ulcer and gastric cancer (1), as well as a number of extragastric infections, including vascular, respiratory, liver, skin, and kidney diseases, worldwide (2)(3)(4). Based on available literature, a H. pylori infection model, related to prostate and bladder diseases, has been hypothesized (5).…”

Section: Introductionmentioning

confidence: 99%

Failure to Detect Helicobacter pylori DNA in Semen Samples of Patients Referred to the Avicenna Infertility Clinic - Tehran, Iran

Tabriz¹,

Bagheri²,

Saeedi³

et al. 2014

Int J Enteric Pathog

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Background:Helicobacter pylori (H. pylori) is a gram-negative, spiral-shaped, microaerophilic microorganism and a causative agent of many gastrointestinal tract diseases, as well as several extragastric infections. Several studies have suggested the possibility of sexual transmission of these bacteria. Objectives:The aim of the current study Was to determine the possibility of detecting H. pylori DNA in semen samples from infertile men, compared with healthy controls. Patients and Methods: One hundred infertile male patients and 100 age and gender-matched healthy controls have been enrolled in the study. Semen samples collected from each participant, undergone DNA extraction and polymerase chain reaction (PCR) assay to detect the H. pylori. The ß-actin PCR was performed to verify the accuracy of DNA extraction. Results: Each sample was positive in the ß-actin PCR assay. None of the samples, from both patients and controls, showed positive PCR results. Consequently, statistical analysis was impossible to perform. Conclusions: We could not confirm the presence of H. pylori DNA in semen samples, but this does not exclude the possibility of male urethral colonization by this organism. Further studies with similar results are necessary to certify this hypothesis.

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Helicobacterspecies sequences in liver samples from patients with and without hepatocellular carcinoma

Abstract: Helicobacter spp., carcinogenic in mice, were found at a higher frequency in the liver of patients with HCV-related cirrhosis and HCC than those in patients without primary liver disease.

Cited by 95 publications

References 26 publications

Enterohepatic Helicobacter other than Helicobacter pylori

Enterohepatic Helicobacter other than Helicobacter pylori

Low frequency of Helicobacter DNA in benign and malignant liver tissues from Baltimore, United States

Failure to Detect Helicobacter pylori DNA in Semen Samples of Patients Referred to the Avicenna Infertility Clinic - Tehran, Iran

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