Helicobacter pylori and Non‐malignant Diseases

Abstract

It is well known that Helicobacter pylori infection is associated with many nonmalignant disorders such as gastritis, peptic ulcer, gastroesophageal reflux disease (GERD), gastric polyp, nonsteroidal anti-inflammatory drug (NSAID)/aspirin-induced gastric injury, and functional dyspepsia. In 2008, interesting articles on the association of H. pylori infection with these disorders were presented, some of which intended to reveal the mechanisms of inter-individual differences in response to H. pylori infection, and have demonstrated that genetic differences in host and bacterial factors as well as environmental factors account for these differences. A decline in the occurrence of peptic ulcer related to H. pylori was confirmed. An inverse relationship between H. pylori infection and GERD was also confirmed but the impact of gastric atrophy on the prevention of GERD remained debatable. For NSAID-induced gastric injury, eradication of H. pylori infection has been recommended. During this year, eradication of H. pylori infection was recommended for patients treated with antiplatelet therapy as well as aspirin and NSAID. It was also reported that for patients with functional dyspepsia, eradication of H. pylori offers a modest but significant benefit.

Risk Factors for <i>Helicobacter pylori</i> Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers

“…A recent study in Japan indicated that the Helicobacter pylori ( H. pylori ) infection rate increased with age by around 1% per year, whereas the population-wide infection rate decreased in a time-dependent manner ( 1 ). Several diseases, such as peptic ulcers, mucosa-associated lymphoid tissue lymphoma, gastric cancers and chronic gastritis, are induced by H. pylori infection ( 2 , 3 ). Chronic gastritis, including nodular gastritis, has been recognized in relatively young adults ( 4 , 5 ), but the prevalence of nodular gastritis in young Japanese adults is still unclear.…”

Novel Functions for Glycosyltransferases Jhp0562 and GalT in Lewis Antigen Synthesis and Variation in Helicobacter pylori

“…If left untreated with antibiotics, colonization with H. pylori can continue for the lifetime of the host and can result in the development of peptic ulcer disease (14) or gastric adenocarcinoma (38). To flourish within the host for such long durations, H. pylori has developed adaptations that mediate persistence, including evasion of innate and adaptive immune responses (reviewed in reference 25) and maintenance of high levels of genetic diversity (10,11,28,47).…”

Is Helicobacter Pylori Associated with an Increased Complication Rate after Sleeve Gastrectomy?

“…1 Helicobacter pylori infection has been associated with several pathologic changes such as gastritis and ulcers, and has also been implicated in gastric malignancies such as mucosa-associated lymphoid tissue (MALT) lymphoma. [2][3][4] The prevalence of H. pylori infection is 30-50% in the United States. 5 Among bariatric surgery patients tested preoperatively, studies report a prevalence ranging from 20% to 50%.…”