<i>Helicobacter pylori</i>: Bacterial Strategy for Incipient Stage and Persistent Colonization in Human Gastric Niches

Rhee, Kwang‐Ho; Park, Jin-Sik; Cho, Myung-Je

doi:10.3349/ymj.2014.55.6.1453

Cited by 25 publications

(22 citation statements)

References 93 publications

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“…Due to the properties of the gastric mucosa, H. pylori adhesion and survival in such an environment depend on many mechanisms and specific virulence factors [6]. Strains that live in the gastric mucosa and how they interact with the host's immune system determine the H. pylori long-term colonization with chronic gastritis induction [7]. Also, human genetic polymorphisms contribution to the susceptibility and clinical evolution of the infection was reported.…”

Section: Introductionmentioning

confidence: 99%

Association Between Vitamin D Receptor Gene Polymorphisms and Helicobacter Pylori Infection

Mohamed¹,

Moussa²,

Shaheen³

et al. 2020

TOBIOMJ

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Background & Aims: Human genetic polymorphism has been reported in the susceptibility and clinical development of infection. In this regard, this study aimed to investigate the link between Vitamin D Receptor (VDR) gene polymorphism and H. pylori infection. Materials and Methods: This cross-sectional study was conducted on 224 adult patients with upper gastrointestinal symptoms who underwent an upper gastrointestinal endoscopy between July 2017 and May 2019 in two major university hospitals. All patients were evaluated for helicobacter pylori infection. Two gastric antral biopsy specimens were taken from each patient. One of those Biopsy specimens was evaluated for histopathology examination and the other one was immersed in a saline solution ready for genomic DNA extraction. Results: There were statistically significant differences between different genotypes of VDR rs7975232 polymorphism between H. pylori infected and non-infected groups (CC was higher in H. pylori negative and AC and AA were the most common in H. pylori positive group). There were statistical differences between different genotypes of VDR rs2228570 between H. pylori infected and non-infected groups (TT was higher in H. pylori negative and CT and CC were the most common in H. pylori positive group). Regarding VDR rs 7975232 gene polymorphisms; the (A) allele was significantly higher H. pylori infected, while (C) allele was significantly higher in uninfected patients. Regarding VDR rs 2228570 gene polymorphisms; the (C) allele was significantly higher H. pylori infected, while (T) allele was significantly higher in uninfected patients. Conclusion: There is a possible association between the FokI and Apal VDR polymorphism and H. pylori infection.

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Section: Introductionmentioning

confidence: 99%

Association Between Vitamin D Receptor Gene Polymorphisms and Helicobacter Pylori Infection

Mohamed¹,

Moussa²,

Shaheen³

et al. 2020

TOBIOMJ

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“…27 It drives toward the more hospitable environment, that is, toward the mucous membrane of gastric epithelium, an abundance of ammonium carbonate, neutral pH, amino acid, and cholesterol via chemotactic properties. 28 The flagella may play an important role in the colonization and pathogenesis of H. pylori. Apart from important flagellar filament proteins, FlaA and FlaB, there are more than 40 proteins that are involved in the flagellar biosynthesis and functioning.…”

Section: Motility Of H Pylorimentioning

confidence: 99%

“…Flagella drive to the H. pylori into the mucosa of host epithelium makes it even easier to survive it in such atmospheres since H. pylori is not an acidophil . It drives toward the more hospitable environment, that is, toward the mucous membrane of gastric epithelium, an abundance of ammonium carbonate, neutral pH, amino acid, and cholesterol via chemotactic properties . The flagella may play an important role in the colonization and pathogenesis of H. pylori .…”

Section: Introductionmentioning

confidence: 99%

Unraveling the factors and mechanism involved in persistence: Host‐pathogen interactions in Helicobacter pylori

Gupta

Maurya

Verma

et al. 2019

J of Cellular Biochemistry

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Helicobacter pylori and humans have one of the most complex relationships in nature. How a bacterium manages to live in one of the harshest and hostile environments is a topic of unraveling mysteries. H. pylori is a prevalent species and it colonizes the human gut of more than 50% of the world population. It infects the epithelial region of antrum and persists there for a long period. Over the time of evolution, H. pylori has developed complex strategies to extend the degree of inflammation in gastric mucosa. H. pylori needs specific adaptations for initial colonization into the host environment like helical shape, flagellar movement, chemotaxis, and the production of urease enzyme that neutralizes acidic environment of the stomach. There are several factors from the bacterium as well as from the host that participate in these complex interactions. On the other hand, to establish the persistent infection, H. pylori escapes the immune system by mimicking the host antigens. This pathogen has the ability to dodge the immune system and then persist there in the form of host cell, which leads to immune tolerance. H. pylori has an ability to manipulate its own pathogen‐associated molecular patterns, which leads to an inhibition in the binding with specific pattern recognition receptors of the host to avoid immune cell detection. Also, it manipulates the host metabolic homeostasis in the gastric epithelium. Besides, it has several genes, which may get involved in the acquisition of nutrition from the host to survive longer in the host. Due to the persistence of H. pylori, it causes chronic inflammation and raises the chances of gastric cancer. This review highlights the important elements, which are certainly responsible for the persistence of H. pylori in the human host.

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“…H. pylori can grow at a pH ~5.1, which is the pH of the gastric content immediately after food ingestion (Rhee, Park, and Cho 2014). The bacterium can therefore resist these acidic conditions when ingested with food, allowing it to colonise the host's stomach.…”

Section: H Pylori Nichementioning

confidence: 99%

“…Helicobacter pylori has had the ability to colonise human stomachs for thousands of years (Moodley et al 2012). It can also live within its host for years (Rhee, Park, and Cho 2014), and different strains can cohabit within the same host (Cao et al 2015).…”

Section: Long-term Genomic Evolution Of H Pylori In Americasmentioning

confidence: 99%

Genome evolution and virulence in H. pylori: Identifying the genes/alleles underlying phenotype variation

Berthenet¹

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An estimated 50% of all people carry the stomach bacterium Helicobacter pylori (H. pylori). This organism is responsible for gastric problems like gastritis and gastric ulcers, and is one of the major causes of gastric cancer worldwide. Large numbers of people carry this organism asymptomatically and many questions remain about why serious symptoms develop in a subset of infected humans. These extremely recombinant bacteria may take different evolutionary trajectories in different people, and some genomic changes may be associated with gastric cancer. To test this, and learn more about the genetics of cancer-associated H. pylori, different approaches were used. First, evolution of H. pylori populations was investigated looking at both core and accessory genomes and revealed traces of the long and complex history of the Americas in the bacterial genomes, as well as a similar evolution in core and accessory genome. This was the first time accessory genome of H. pylori was studied that way. Secondly, evolution occurring in the bacterial genome during colonisation of a single host was studied in mice model. This analysis revealed small changes during the passage from a human host to a mice host, and during the long-term colonisation of mice stomach. Then a Genome Wide Association Study (GWAS) approach was applied to a large isolate collection sampled across Europe comprising strains isolated from cancer patients and strains from asymptomatic or gastritissuffering patients. This approach identified 11 polymorphisms in 9 genes (3 cagPAI genes, babA, hpaA, 1 outer membrane protein coding gene HP1055 and 3 other core genes (HP0747, HP0709 and HP0468) associated with cancer and a preliminary risk score was built to identify high risk strains. Finally, variations observed among clinical isolates of H. pylori from European patients with different pathologies in terms of motility and ability to trigger cytokine production in two types of cells were quantified. Motility variations were not associated with the disease type, but a link was observed for cytokine production. This was compared to genomic variations, confirming the role of known genomic factors such as cagPAI genes and sheding light to possible functions of a number of new genes.

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Helicobacter pylori: Bacterial Strategy for Incipient Stage and Persistent Colonization in Human Gastric Niches

Cited by 25 publications

References 93 publications

Association Between Vitamin D Receptor Gene Polymorphisms and Helicobacter Pylori Infection

Association Between Vitamin D Receptor Gene Polymorphisms and Helicobacter Pylori Infection

Unraveling the factors and mechanism involved in persistence: Host‐pathogen interactions in Helicobacter pylori

Genome evolution and virulence in H. pylori: Identifying the genes/alleles underlying phenotype variation

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