<i>Helicobacter pylori</i>eradication for the prevention of gastric neoplasia

Ford, Alexander C.; Yuan, Yuhong; Forman, David; Hunt, Richard H.; Martin, Paul

doi:10.1002/14651858.cd005583.pub3

Cited by 96 publications

(107 citation statements)

References 91 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…For NCGA, which accounts for most gastric cancer cases globally, H pylori infection plays a leading role in pathogenesis, with an attributable risk of 80%-90%. 53,54 Although an estimated 4.4 billion people worldwide are infected with H pylori, there are marked global and regional variations in prevalence. In high-prevalence areas, colonization generally occurs in early childhood, 7 which is 39 Rate ratio Japan 1.7 (0.77-3.9) 5.6-6.5 a China 0.37 (0.16-0.86) 1.8-7.9 a important because it is the cumulative time of exposure to H pylori infection that is a strong determinant of cancer risk.…”

Section: Discussionmentioning

confidence: 99%

Increased Incidence and Mortality of Gastric Cancer in Immigrant Populations from High to Low Regions of Incidence: A Systematic Review and Meta-Analysis

Pabla

Shah

Corral

et al. 2020

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

BACKGROUND & AIMS:Gastric cancer is the leading cause of infection-related cancer death and the third-leading cause of cancer death worldwide. The effect of immigration on gastric cancer risk is not well-defined but might be helpful for screening or surveillance endeavors. We performed a systematic review and meta-analysis to define the risk of gastric cancer in immigrants from high-incidence regions to low-incidence regions (including Western that identified immigrants from high-incidence regions of gastric cancer, provided clear definitions of immigrant and reference populations, and provided sufficient data to calculate gastric cancer incidence and gastric cancer-related mortality. We performed meta-analyses of standardized incidence ratios (SIR) for first-generation immigrants from high-to low-incidence regions, stratified by immigrant generation, sex, and anatomic and histologic subtype, when data were available. RESULTS:We identified 38 cohort studies that met our inclusion criteria. All 13 studies of 21 distinct populations reported significantly increased SIRs for gastric cancer in first-generation foreignborn immigrants (men SIR range, 1.24-4.50 and women SIR range, 1.27-5.05). The pooled SIR for immigrants with all types of gastric cancer was 1.66 (95% CI, 1.52-1.80) for men and 1.83 (95% CI, 1.69-1.98) for women. Nine studies from 2 high-incidence populations (the former Soviet Union and Japan) reported an increased gastric cancer standardized mortality ratio in first-generation immigrants who migrated to regions of low incidence (former Soviet Union immigrants, 1.44-1.91 for men and 1.40-2.56 for women). CONCLUSIONS:Immigrants from regions with a high incidence of gastric cancer to regions of low incidence maintain a higher risk of gastric cancer and related mortality, based on a comprehensive systematic review and meta-analysis. Assessment of immigrant generation along with other risk factors might help identify high-risk populations for prevention and therapeutic interventions.

show abstract

Section: Discussionmentioning

confidence: 99%

Increased Incidence and Mortality of Gastric Cancer in Immigrant Populations from High to Low Regions of Incidence: A Systematic Review and Meta-Analysis

Pabla

Shah

Corral

et al. 2020

Clinical Gastroenterology and Hepatology

View full text Add to dashboard Cite

show abstract

“…Helicobacter pylori eradication can reduce the risk of gastric cancer, as well as effectively prevent peptic ulcer and H. pylori ‐associated dyspepsia. The data indicate that the implementation of the “ H. pylori eradication strategy” for preventing gastric cancer will be cost‐effective in Asian countries with a high incidence of gastric cancer . In China, endoscopy and the H. pylori test and most drugs for eradicating H. pylori have a low cost, and the detection rate of early gastric cancer is low .…”

Section: H Pylori Infection and Gastric Cancermentioning

confidence: 99%

Fifth Chinese National Consensus Report on the management ofHelicobacter pyloriinfection

et al. 2018

View full text Add to dashboard Cite

show abstract

“…The latter is relevant because initial H. pylori treatment is only 50%‐85% successful, persistent H. pylori infection may be associated with serious long‐term sequelae, symptoms are not a reliable sign of the presence or absence of infection after treatment, and patients may desire evidence that the infection has cleared . Furthermore, meta‐analyses have shown that eradication of H. pylori promotes ulcer healing, prevents ulcer recurrence, and decreases the incidence of gastric malignancy …”

Section: Background and Aimsmentioning

confidence: 99%

Helicobacter pylori‐associated peptic ulcer disease: A retrospective analysis of post‐treatment testing practices

Feder

Posner

et al. 2018

Helicobacter

View full text Add to dashboard Cite

Background & Aims Guidelines recommend that patients with Helicobacter pylori (H. pylori)‐associated peptic ulcer disease (PUD) receive H. pylori eradication therapy followed by post‐treatment testing to prove eradication; however, post‐treatment testing rates are suboptimal and barriers to testing are poorly understood. Our aim was to identify factors that predicted receipt of post‐treatment testing. Methods We performed a retrospective cohort study of 152 patients with H. pylori‐associated PUD diagnosed between 2007 and 2015 at a large tertiary medical center in the United States, who received standard eradication therapy and ambulatory follow‐up within one year. The primary outcome of interest was receipt of post‐treatment testing. Logistic regression models compared post‐treatment testing rates in those diagnosed while outpatient vs inpatient, patients with vs without repeat endoscopy, and patients with vs without gastroenterology (GI) clinic follow‐up. Propensity scores controlled for age, sex, race, ulcer location, and symptom persistence. Results Among 152 patients, 67 (44%) patients received post‐treatment testing. There were significant differences in post‐treatment testing rates in those diagnosed as outpatients vs inpatients (57% vs 33%; OR 3.87, P = 0.001) and in patients with vs without GI follow‐up (62% vs 11%; OR 9.85, P < 0.0001). Conclusions The rate of testing for eradication after treatment in patients with H. pylori‐ associated PUD was low. However, this was significantly improved in patients who have GI follow‐up and whose diagnosis was made in the outpatient setting. Our study demonstrates a clear opportunity for quality improvement initiatives.

show abstract

Helicobacter pylorieradication for the prevention of gastric neoplasia

Abstract: Helicobacter pylori eradication for the prevention of gastric neoplasia.

Cited by 96 publications

References 91 publications

Increased Incidence and Mortality of Gastric Cancer in Immigrant Populations from High to Low Regions of Incidence: A Systematic Review and Meta-Analysis

Increased Incidence and Mortality of Gastric Cancer in Immigrant Populations from High to Low Regions of Incidence: A Systematic Review and Meta-Analysis

Fifth Chinese National Consensus Report on the management ofHelicobacter pyloriinfection

Helicobacter pylori‐associated peptic ulcer disease: A retrospective analysis of post‐treatment testing practices

Contact Info

Product

Resources

About