Helicobacter pyloriEradication Lowers Serum Asymmetric Dimethylarginine Levels

Abstract

Introduction. Microbial pathogens, one of them is Helicobacter pylori (H. pylori), have frequently been implicated in the atherogenesis. Endothelium-derived nitric oxide (NO) is synthesized from L-arginine by nitric oxide synthase (NOS) and plays a pivotal role in the regulation of vascular tone. Asymmetric dimethylarginine (ADMA) is the most potent endogenous NOS inhibitor. Elevated levels of ADMA have been reported in many circumstances associated with a high cardiovascular risk. The aim of the present study was to investigate whether the eradication of H. pylori infection affects serum ADMA levels. Materials and Methods. Forty-two H. pylori-positive patients were enrolled in the study. Triple therapy for 14 days were given to all patients. Serum ADMA levels were measured at baseline and 2 months after therapy. Results. Eradication was achieved in 34 (81%) patients. The mean serum ADMA levels before and after therapy were 1, 77 ± 0, 30 and 1, 67 ± 0, 29 ng/mL in the group with H. pylori eradicated and 1, 63 ± 0, 28 and 1, 56 ± 0, 32 ng/mL in the noneradicated, respectively. We detected statistically significant decreased serum ADMA levels after therapy in H. pylori eradicated group. Conclusion. These findings have indicated that eradication of H. pylori infection may decrease the risk of atherosclerosis and cardiovascular events.

Changes in Serum Levels of ADMA, SDMA and L-NMMA with Helicobacter Pylori Eradication

“…In our study, a significant decrease was observed with H. pylori eradication in ADMA levels, as in the study by Aydemir et al (7). In addition, a significant decrease in eradication treatment was first revealed in other methylarginine metabolism products (SDMA and L-NMMA) in our study.…”

“…The only study evaluating H. pylori eradication and ADMA levels was conducted by Aydemir et al (7). In their study, a significant decrease was reported in serum ADMA levels of patients in whom H. pylori eradication was provided.…”

“…Clinical and experimental studies have demonstrated that H. pylori infection caused increased levels of ADMA (6). Despite several studies on the importance of ADMA in the development of endothelial dysfunction in the literature, there are a few studies evaluating the relationship between H. pylori infection and ADMA levels (7)(8)(9). The aim of the present study is to evaluate the effect of eradication treatment on the serum levels of ADMA, symmetric dimethylarginine (SDMA), and N-monomethyl-l-arginine (L-NMMA) in individuals infected with H. pylori.…”

Helicobacter pylori—An Infectious Risk Factor for Atherosclerosis?

“…Heat shock proteins (HSPs), highly conserved decreases the risk of cardiovascular disease by decreasing the serum ADMA level 67,68) . In addition to evidence suggesting a link between H. pylori infection and endothelial dysfunction, there are contradictory data showing no association between H. pylori infection and the endothelial function 69,70) .…”

Efficient tumorigenesis by mutation-induced failure to terminate microRNA-mediated adaptive hyperplasia

“…Vascular wall infection by Chlamydophila pneumonia induces SMC proliferation and elevates risk of coronary heart disease [267,268], and similar effects are suspected for vascular infection by Helicobacter pylori [269,270]. The DAH hypothesis predicts that SMC hyperplasia induced by vascular-wall bacterial infection is an example of P-type AH, which is mediated and sustained by an epigenetically maintained miRNA profile similar to that observed in hyperplastic SMCs [257], as can readily be tested using methods mentioned above.…”