<i>Helicobacter pylori</i> in Colorectal Carcinoma Tissue

Bulajić, Milutin; Štimec, Bojan; Jesenofsky, Ralf; Kecmanović, Dragutin; Ceranic, Miljan; Kostić, Nada; Schneider-Brachert, Wulf; Lowenfels, Albert B.; Maisonneuve, Patrick; Löhr, Matthias

doi:10.1158/1055-9965.epi-06-1031

Cited by 25 publications

(21 citation statements)

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“…Some studies were able to identify the genetic material of the bacteria in colonic neoplasias (3,8,15) . The effect of the intestinal flora as a carcinogenic agent has been evaluated and the possibility exists that bacteria such as H. pylori circulating in the intestines could directly activate carcinogenesis (33) .…”

Section: Resultsmentioning

confidence: 99%

Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospital

Buso

Rocha

Diogo

et al. 2009

Arq. Gastroenterol.

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-Context -The association between Helicobacter pylori infection and colon neoplasia has been the subject of recent investigations which have produced controversial results. Objective -To evaluate the prevalence of H. pylori infection in patients with colonic adenomas and also in patients whose colonoscopy exams were normal. Methods -After colonoscopy, the individuals were distributed into two groups: patients with colon adenomas (cases) and patients whose colons were normal (controls). The groups were similar regarding age and gender. The individuals of both groups were subjected to a dosage of IgG antibody against H. pylori. The dosage was applied according to the solid phase, chemiluminescent immunometric assay. The chi-square test was used to analyze the data. Results -There were 30 men and 64 women in each group (94 cases and 94 controls). The mean age of the cases was 59.79 ± 12.25 years and that of the controls was 58.98 ± 11.55 years. The H. pylori serology was positive for 66 (70.21%) of the cases and for 51 (54.25%) of the controls. There was a significant difference (P = 0.024). The odds ratio was 1.98 (CI 95%, 0.82-3.15). The prevalence of H. pylori in cases and controls according to gender, histological type and location of the colon lesions showed a significant difference only among women (P = 0.03), among patients with tubular adenomas (P = 0.03), and in those with distal adenomas (P = 0.038). Conclusion -There is a positive association between H. pylori infection and colonic adenomas. This association is more evident in women, especially for tubular adenomas and distal colonic location. HEADINGS -Helicobacter pylori. Adenoma. Colonic neoplasms. Helicobacter infections.

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Section: Resultsmentioning

confidence: 99%

Seroprevalence of Helicobacter pylori in patients with colon adenomas in a brazilian university hospital

Buso

Rocha

Diogo

et al. 2009

Arq. Gastroenterol.

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“…Like serologic studies, studies using PCR methods have been equivocal. Two studies found that detection of H. pylori via PCR was significantly higher in colorectal adenocarcinoma tissues compared with normal colorectal tissues (Grahn et al, 2005;Jones et al, 2007), but a third study found that only 1.2% of malignant colorectal tissue samples were positive for H. pylori, compared with 6% of normal tissues (Bulajic et al, 2007). The 13C-urea breath test has 97% sensitivity and specificity in H. pylori detection (Chen et al, 2003); however, as in PCR-based studies, the evidence is not convincing.…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection and the Risk of Colorectal Adenoma and Adenocarcinoma: an Updated Meta-analysis of Different Testing Methods

Chen¹,

Xu²,

Ding³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…Nested PCR was used to detect H. pylori in the isolated DNA samples as previously described [8,9]. In order to exclude a methodological bias, the samples were analyzed blindly in 2 different laboratories, using either conventional or LightCycler PCR for H. pylori urease A and 16S ribosomal DNA.…”

Section: Methodsmentioning

confidence: 99%

“…Firstly, it is a factor acknowledged by the UICC (International Union against Cancer) to cause inflammation and cancer, primarily of the stomach [7]. Secondly, Helicobacter species have been found in biliary tract [8], but not in colorectal malignancies [9]. Thirdly, smoking and alcohol, both contributing to the development of chronic pancreatitis and pancreatic cancer [10,11], promote Helicobacter infections [12].…”

Section: Introductionmentioning

confidence: 99%