<i>Helicobacter pylori</i> independent chronological change in gastric acid secretion in the Japanese

Kinoshita, Yoshikazu; Kawanami, Chiharu; Kishi, Kiyohiko; Nakata, Hirohisa; Seino, Yutaka; Chiba, Tsutomu

doi:10.1136/gut.41.4.452

Cited by 158 publications

(147 citation statements)

References 30 publications

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“…Gastric acid secretion in Japanese individuals has been demonstrated to be increasing due to a decrease in the rate of H. pylori infection and the Westernization of eating habits, especially a high protein intake (29). In this study, we investigated changes in the degree of gastric mucosal atrophy and found that it decreased over the 10-year period in both men and women.…”

Section: Discussionmentioning

confidence: 95%

Gender Differences in the Time-Course Changes of Reflux Esophagitis in Japanese Patients

et al. 2015

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Objective Obesity is related to an increased prevalence of reflux esophagitis and gastroesophageal reflux disease symptoms. This study was performed to clarify the influence of gender on time-course changes in the rate of a high BMI and incidence of reflux esophagitis in Japanese subjects. Results A multiple logistic regression analysis showed that a high BMI, milder degree of gastric mucosal atrophy and larger size of diaphragmatic hiatus were significant predictive factors for the presence of reflux esophagitis in both men and women. The number of male subjects with reflux esophagitis and a high BMI increased during the 10-year examination period. In contrast, the number of individuals with reflux esophagitis and a high BMI was not increased among women. For both men and women, the proportions of patients with a large diaphragmatic hiatus and mild gastric mucosal atrophy increased during the 10-year period. Conclusion The prevalence of reflux esophagitis in the female subjects remained constant over 10 years, different from that observed in the men. A lack of change in BMI may be an important factor accounting for the constant prevalence of reflux esophagitis in women.

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Section: Discussionmentioning

confidence: 95%

Gender Differences in the Time-Course Changes of Reflux Esophagitis in Japanese Patients

et al. 2015

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“…Secondly, the population has become increasingly overweight [27] , and obesity may lead to an increase in intragastric pressure [15] . Thirdly, it has been reported Japanese patients have a high incidence of H pylori infection and this leads to an atrophic pattern of gastritis with low acid secretion [28,29] . The declining prevalence of H pylori infection [30] , due to improved hygiene conditions and widespread use of eradication therapy in Japan could also have paradoxically contributed to the increased frequency of GERD.…”

Section: Figurementioning

confidence: 99%

Prevalence of gastroesophageal reflux symptoms in a large unselected general population in Japan

Yamagishi¹,

Koike²,

Ohara³

et al. 2008

WJG

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AIM:To examine the prevalence of gastroesophageal reflux disease (GERD) symptoms in a large unselected general population in Japan. METHODS:In Japan, mature adults are offered regular check-ups for the prevention of gastric cancer. A notice was sent by mail to all inhabitants aged > 40 years. A total of 160 983 Japanese (60 774 male, 100 209 female; mean age 61.9 years) who underwent a stomach check up were enrolled in this study. In addition, from these 160 983 subjects, we randomly selected a total of 82 894 (34 275 male, 48 619 female; mean age 62.4 years) to evaluate the prevalence of abdominal pain. The respective subjects were prospectively asked to complete questionnaires concerning the symptoms of heartburn, dysphagia, and abdominal pain for a 1 mo period. RESULTS:The respective prevalences of the symptoms in males and females were: heartburn, 15.8% vs 20.7%; dysphagia, 5.4% vs 7.8%; and abdominal pain, 6.6% vs 9.6%. Among these symptoms, heartburn was significantly high compared with the other symptoms, and the prevalence of heartburn was significantly more frequent in females than in males in the 60-89-year age group. Dysphagia was also significantly more frequent in female patients. CONCLUSION:The prevalence of typical G ERD symptoms (heartburn) was high, at about 20% of the Japan population, and the frequency was especially high in females in the 60-89 year age group.

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“…It was reported that gastric acid secretion has increased over the past 20 years in Japanese subjects, however, gastric acid secretion is still lower in Japanese subjects than in Europeans or Americans, which may be one reason for lower esophageal acid exposure and smaller number of acidic reflux events in the present study. 21 In this study, weakly acidic reflux was defined as a decrease of more than 1 pH unit with the nadir pH remaining above 4, while non-acidic reflux was defined as no change of pH or a decrease of less than 1 pH unit. Because Sifrim et al 22 reported the importance of weakly acidic reflux (using the same definition as ours) in patients with suspected GERD, we defineded weakly acidic refluxes separately from non-acidic refluxes.…”

Section: Discussionmentioning

confidence: 99%

Liquid-containing Refluxes and Acid Refluxes May Be Less Frequent in the Japanese Population Than in Other Populations: Normal Values of 24- hour Esophageal Impedance and pH Monitoring

Kawamura

Kohata

Kawami

et al. 2016

J Neurogastroenterol Motil

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6Kurokawa general hospital, Miyagi, Japan Background/AimsTwenty-four-hour esophageal impedance and pH monitoring allows detection of all types of reflux episodes and is considered the best technique for identifying gastroesophageal refluxes. However, normative data for the Japanese population are lacking. This multicenter study aimed to establish the normal range of 24-hour esophageal impedance and pH data both in the distal and the proximal esophagus in Japanese subjects. MethodsForty-two healthy volunteers (25 men and 17 women) with a mean ± standard deviation age of 33.3 ± 12.4 years (range: 22-72 years) underwent a combined 24-hour esophageal impedance and pH monitoring. According to the physical and pH properties, distal or proximal esophageal reflux events were categorized. ResultsMedian 45 reflux events occurred in 24 hours, and the 95th percentile was 85 events. Unlike previous reports, liquid-containing reflux events are median 25/24 hours with the 95th percentile of 62/24 hours. Acidic reflux events were median 11/24 hours with the 95th percentile of 39/24 hours. Non-acidic gas reflux events were median 15/24 hours with the 95th percentile of 39/24 hours. Proximal reflux events accounted for 80% of the total reflux events and were mainly non-acidic gas refluxes. About 19% of liquid and mixed refluxes reached the proximal esophagus. ConclusionsUnlike previous studies, liquid-containing and acidic reflux events may be less frequent in the Japanese population. Non-acidic gas reflux events may be frequent and a cause of frequent proximal reflux events. This study provides important normative data for 24-hour impedance and pH monitoring in both the distal and the proximal esophagus in the Japanese population.

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Helicobacter pylori independent chronological change in gastric acid secretion in the Japanese

Cited by 158 publications

References 30 publications

Gender Differences in the Time-Course Changes of Reflux Esophagitis in Japanese Patients

Gender Differences in the Time-Course Changes of Reflux Esophagitis in Japanese Patients

Prevalence of gastroesophageal reflux symptoms in a large unselected general population in Japan

Liquid-containing Refluxes and Acid Refluxes May Be Less Frequent in the Japanese Population Than in Other Populations: Normal Values of 24- hour Esophageal Impedance and pH Monitoring

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