<i>Helicobacter pylori-</i>Induced Immunological Responses in Patients with Duodenal Ulcer and in Patients with Cardiomyopathies

Klausz, Gergely; Tiszai, A; Lénárt, Zsuzsa; Gyulai, Z.; Tiszlavicz, L.; Högye, M; Csanády, Miklós; Lonovics, J.; Mándi, Yvette

doi:10.1556/amicr.51.2004.3.9

Cited by 8 publications

(12 citation statements)

References 14 publications

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“…Pathogen binding to class II majorhistocompatibility-complex (MHC) on the surface of gastric epithelial cells can induce apoptosis (Fan et al, 2000). As noted above, translocation of CagA into the gastric epithelial cells leads to higher levels of proinflammatory cytokines such as TNF-a, IL-6, IL-10, and most importantly, IL-8 (Klausz et al, 2004;Kim et al, 2006). The VacA protein interacts with macrophages, B-and T-lymphocytes.…”

Section: Immunological Response To H Pylori Infectionmentioning

confidence: 99%

Helicobacter pylori and autoimmune diseases

2011

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Helicobacter pylori (H. pylori) is a widely prevalent microbe, with between 50 and 80% of the population infected worldwide. Clinically, infection with H. pylori is commonly associated with peptic ulcer disease, but many of those infected remain asymptomatic. H. pylori has evolved a number of means to affect the host immune response and has been implicated in many diseases mitigated by immune dysregulation, such as immune thrombocytopenic purpura (ITP), atrophic gastritis, and mucosa associated lymphoid tissue (MALT) lymphoma. Autoimmune diseases, such as systemic lupus erythematosus, rheumatoid arthritis, and Sjogren’s syndrome, are the result of a dysregulated host immune system which targets otherwise healthy tissues. The exact etiology of autoimmune diseases is unclear, but it has long been suggested that exposure to certain environmental agents, such as viral and bacterial infection or chemical exposures, in genetically susceptible individuals may be the catalyst for the initiation of autoimmune processes. Because of its prevalence and ability to affect human immune function, many researchers have hypothesized that H. pylori might contribute to the development of autoimmune diseases. In this article, we review the available literature regarding the role of chronic H. pylori infection in various autoimmune disease states.

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Section: Immunological Response To H Pylori Infectionmentioning

confidence: 99%

Helicobacter pylori and autoimmune diseases

2011

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“…Accumulation of profuse amounts of ammonia in the colon is toxic and could lead to pelvic congestion. In addition, the increased mucosal production of inflammatory cytokines of H. pylori could play an integral role in the pathogenesis of ED [18,19].…”

Section: Discussionmentioning

confidence: 99%

Male Pelvic Congestion and Erectile Dysfunction Obscure Reasons for an Obvious Phenomenon among the Young

Nasrat¹,

Sayed²

2016

Gen Med

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The study aimed to demonstrate recent environmental reasons behind the rising phenomena of erectile dysfunction among young ages during late decades.Erectile dysfunction (ED) has got its impact on the quality of life of both partners. Erectile function (EF) is due to local arousal induced by release of nitric oxide. ED can be adequately prevented and improved by reduction of cardiovascular disease risk factors, regular exercise, weight loss and abstinence from smoking. An apparent role for cytokines in the pathophysiology of ED has been emerging; this substance can induce vascular spasm and affect vascular endothelial function including endothelial-derived nitric oxide production (NO). The association of male pelvic congestion with the frequency of male sexual dysfunction has been documented in literature. As concerns therapeutic modalities, medicines work essentially by mediating or enhancing the effect of NO. Colonic H. pylori strains were found frequently associated with pelvic congestion; H. pylori were considered as a possible underlying etiologic pathology in cases of pelvic pathology in general. The increased mucosal production of inflammatory cytokines of H. pylori could play an integral role in the pathogenesis of ED. The association of the colonic H. pylori strains with pelvic pathology, the role played by the inflammatory cytokines and the therapeutic effect of NO in ED were the scientific reasons to employ colon clear and blood-let out (BLO) cupping therapy in cases of ED. 40 patients with ED positive for colonic H. pylori strains were selected in two age groups; young and older age groups. They were scheduled for three sessions of colon clear, one each month, and a procedure BLO cupping therapy one week after the last colon clear. Marked improvement and most patients recovered their usual EF and sexual satisfaction. Employment of combined colon clear and cupping therapy in cases of ED is promising and is not just hypothetical.

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“…The association of H. pylori with autoimmune disorders and chronic idiopathic dermatitis was sufficiently reported [10]. The role played by the increased mucosal production of inflammatory mediators (cytokines) induced by H. pylori was also clearly illustrated [11,12].…”

Section: Discussionmentioning

confidence: 99%

Therapeutic Effect of Combined Colon Clear and Cupping Therapy on Idiopathic Skin Pathology

Nasrat¹,

Nasrat²,

Nasrat³

et al. 2015

Gen Med (Los Angel)

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The study aimed at demonstration of idiopathic skin pathology; influence of Helicobacter pylori and therapeutic effect of combined colon clear with cupping therapy.The complex spectrum of inflammatory skin diseases is ever expanding and evolving particularly in psoriasis, idiopathic eczema and atopic dermatitis. The etiology of these inflammatory atopic dermato-pathological disorders is still obscure but it is basically autoimmune triggered and maintained by an aberrant response of the skin immune system cells. Pro-inflammatory cytokines play a pivot role in the pathogenesis of immune skin pathologies. H. pylori could migrate or get forced to migrate to the colon leading to accumulation of profuse toxic amounts of ammonia unopposed or buffered by any acidity. The association of H. pylori with autoimmune disorders and chronic idiopathic dermatitis was sufficiently reported. The role played by the increased mucosal production of inflammatory mediators (cytokines) induced by H. pylori was also clearly illustrated. Antibiotics are seldom effective against extra-gastric H. pylori strains. A potent natural purgative is the only measure to eradicate H. pylori strains migrated to the colon. Elimination of toxic metabolites and inflammatory mediators from the body is a challenge which is only feasible via seroclearance blood-let out cupping therapy.Seven patients with atopic dermatitis, seven with idiopathic eczema and seven with psoriasis were randomly included in the study on the basis of being newly discovered, not starting any definitive treatment and having a frank history of H. pylori dyspepsia which was proved by sensitive specific tests. All patients underwent colon clear employing the potent natural senna purge which was followed in five days by a session of blood-let out seroclearance cupping therapy on the upper back.Marked improvement as regards the scales, itchiness and discoloration was seen in 5 patients with dermatitis, 6 patients with eczema and 4 patients with psoriasis after colon clear. Improvement was much more marked after cupping therapy.On conclusion, combined natural colon clear and blood-let out cupping therapy should be considered as a potent adjuvant therapeutic measure in idiopathic immune skin disorders associated with H. pylori.

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Helicobacter pylori-Induced Immunological Responses in Patients with Duodenal Ulcer and in Patients with Cardiomyopathies

Cited by 8 publications

References 14 publications

Helicobacter pylori and autoimmune diseases

Helicobacter pylori and autoimmune diseases

Male Pelvic Congestion and Erectile Dysfunction Obscure Reasons for an Obvious Phenomenon among the Young

Therapeutic Effect of Combined Colon Clear and Cupping Therapy on Idiopathic Skin Pathology

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