2020
DOI: 10.1111/hel.12754
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Helicobacter pylori infection and eradication: Exploring their impacts on the gastrointestinal microbiota

Abstract: The rapid development of microbiota research has remolded our view of human physiological and pathological processes. Among all the gastrointestinal microorganisms, Helicobacter pylori (H pylori) is probably the most notorious constituent. Although half of the adults worldwide are infected with H pylori, their clinical manifestations vary widely, suggesting other microorganisms beyond H pylori may play a role in determining clinical outcomes. Recently, many studies have put effort into elucidating the crosstal… Show more

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Cited by 24 publications
(18 citation statements)
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References 87 publications
(177 reference statements)
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“…As a part of the human ecosystem, microbial community imbalance is related to many pathological processes. With the development of sequencing technology, it has been found that there is also a bacterial ecosystem in the stomach [ 41 , 42 ]. There is continuous evidence that H. pylori infection can reshape the gastrointestinal flora through host–microbe interaction or microbe–microbial interaction.…”
Section: Discussionmentioning
confidence: 99%
“…As a part of the human ecosystem, microbial community imbalance is related to many pathological processes. With the development of sequencing technology, it has been found that there is also a bacterial ecosystem in the stomach [ 41 , 42 ]. There is continuous evidence that H. pylori infection can reshape the gastrointestinal flora through host–microbe interaction or microbe–microbial interaction.…”
Section: Discussionmentioning
confidence: 99%
“…Although the mechanisms underlying H. pylori infection associated alterations in gut microbiota are still unknown, some studies have suggested possible contributing factors; these included host immune responses, virulence factors, physical contact and modification of gastric acidity[ 4 , 27 ]. A previous study performed using a transgenic Drosophila model revealed that the virulence factor, cytotoxin-associated gene A (CagA), of H. pylori may contribute to gut microbiota dysbiosis[ 28 ].…”
Section: The Mechanisms Underlying H Pylori Infection Induced Gut Microbiotamentioning
confidence: 99%
“…The altered host immune response may also modulate the gut microbiota[ 9 , 32 ]. A previous review suggested the possibility of a direct interaction of H. pylori , which migrates from the stomach towards the intestinal tract, with the local gut microbiota[ 4 ]. However, this hypothesis is yet to be proven.…”
Section: The Mechanisms Underlying H Pylori Infection Induced Gut Microbiotamentioning
confidence: 99%
See 1 more Smart Citation
“…Helicobacter pylori ( H pylori ), as we all know, is a notorious gastrointestinal microorganism, which can lead to chronic gastritis, peptic ulcer, and even evolve into gastric cancer. [ 1 ] Besides, H pylori infection is also associated with extragastric diseases, especially cardiovascular, metabolic, and neurologic disorders. [ 2 , 3 ] In the world, more than half of the human population is infected with H pylori .…”
Section: Introductionmentioning
confidence: 99%