<i>Helicobacter pylori</i> infection and its related factors in junior high school students in Nagano Prefecture, Japan

Nakayama, Yoshiko; Lin, Yingsong; Hongo, Minoru; Hidaka, Hiroya; Kikuchi, Shogo

doi:10.1111/hel.12363

Cited by 28 publications

(34 citation statements)

References 46 publications

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“…The study population consisted of thirteen subjects with serum/urinary H pylori antibody positivity, who agreed to enrollment in the H pylori epidemiological study performed as a part of a lifestyle‐related disorder prevention program at four junior high schools in Nagano and received eradication therapy at our university hospital in Nagano between 2012 and 2015. The detail regarding the epidemiological study and part of results were previously published . In this study, we updated the epidemiological data with addition of data collected for 2014‐2015.…”

Section: Methodsmentioning

confidence: 99%

“…Previously, we conducted an epidemiological study screening for H pylori antibody positivity to clarify the prevalence of H pylori infection among Japanese junior high school students. The results indicated a prevalence of 3.1% among junior high school students in Nagano Prefecture, Japan . However, the clinical features of infected children and adolescents, such as the extent of gastritis or gastric atrophy and associations with abdominal pain and anemia, have not been clearly defined.…”

Section: Introductionmentioning

confidence: 96%

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Clinical features of Helicobacter pylori antibody‐positive junior high school students in Nagano Prefecture, Japan

et al. 2018

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Background Previously, we conducted an epidemiological study screening for Helicobacter pylori antibody positivity among Japanese junior high school students. In this study, we updated the epidemiological data and assessed the clinical features of H pylori antibody‐positive junior high school students. Materials and methods We assessed H pylori antibody‐positive subjects who were identified between 2012 and 2015 at four junior high schools in Nagano Prefecture, Japan. H pylori infection was confirmed by urea breath test (UBT) or endoscopic examination. Endoscopy was performed after obtaining consent from the subject and their guardians. Eradication therapy consisted of triple therapy with proton pump inhibitor (PPI), amoxicillin (AMPC), and clarithromycin (CAM) or metronidazole (MNZ) for seven days. Eradication of H pylori was confirmed by UBT. We reviewed subjects’ characteristics, endoscopic findings, histological findings, eradication regimes, outcomes, and adverse effects. Results The overall prevalence of H pylori antibody positivity was 3.2% (42/1298). We assessed thirteen H pylori antibody‐positive subjects. Eight subjects had a family history of H pylori infection. Six subjects had abdominal pain, and two subjects had iron deficiency anemia (IDA). Twelve subjects underwent endoscopy; one subject had duodenal ulcer, eleven subjects had antral nodular gastritis, and six subjects showed grade 2 closed type atrophic border according to the Kimura‐Takemoto classification. All subjects received eradication therapy; CAM was used in five subjects with CAM susceptibility as well as in three subjects with unknown information on CAM susceptibility, and MNZ was used in five subjects with CAM resistance. Eradication was successful in twelve subjects (one unconfirmed). There were three mild adverse effects (abdominal pain or diarrhea). Conclusions Helicobacter pylori test for junior high school students represents an opportunity to diagnose the peptic ulcer, iron deficiency anemia, and gastric atrophy.

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Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Clinical features of Helicobacter pylori antibody‐positive junior high school students in Nagano Prefecture, Japan

et al. 2018

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“…Studies from Japan have also shown a considerable fall of H. pylori prevalence in childhood. One study from a high GC incidence area found only 85 of 1,765 (4.8%) students aged 13‐15 years to be positive, and in another the prevalence in school children aged 12‐15 years was 3.1% . Inoue reported that Japanese generations born before 1950 have a high prevalence of around 80%‐90%, decreasing with age to reach around 10% or less in those born around the 1990s, and less than 2% for those born after year 2000.…”

Section: Prevalence Of H Pylori and Recent Changesmentioning

confidence: 99%

Epidemiology of Helicobacter pylori infection

2017

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The study of Helicobacter pylori genetic variability brought us interesting data on the history of mankind. Based on multilocus sequence typing and more recently on whole-genome sequencing, paleomicrobiology still attracts the attention of global researchers in relation to its ancestor roots and coexistence with humans. Three studies determining the prevalence of virulence factors illustrates the controversial results obtained since 30 years by studies trying to associate prevalence of different virulence markers and clinical outcomes of H. pylori infection. Three articles analyzed the prevalence and risk of multiple (genetically distinct isolates) and mixed (susceptible and resistant isolates) infections. A number of studies confirm that H. pylori prevalence is falling worldwide especially in the developed world and in children but that the level of infection is higher in certain ethnic minorities and in Migrants. There is little new in identifying the mode of H. pylori transmission though intrafamilial spread appears to be important. There have, however, been some interesting papers on the presence of the organism in food, water, and the oral cavity.

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“…H. pylori status was assessed by ELISA and then by UBT. The overall prevalence of H. pylori was 3.1% (14/454) …”

Section: Epidemiologymentioning

confidence: 99%

Helicobacter pylori infection in children

2017

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Helicobacter pylori infection in children differs from that in adults, from the point of view of epidemiology, host response, clinical features, related diseases, and diagnosis, as well as treatment strategies. The prevalence of H. pylori infection, in both children and adults, is decreasing in the Western World as well as in some developing countries, which contrasts with the increase in childhood asthma and allergic diseases. Recurrent abdominal pain is not specific during H. pylori infection in children. The role of H. pylori infection and failure to thrive, children's growth, type I diabetes mellitus (T1DM) and celiac disease remains controversial. The main initial diagnosis is based on upper digestive endoscopy with biopsy-based methods. Nodular gastritis may be a pathognomonic endoscopic finding of childhood H. pylori infection. The infection eradication control is based on validated noninvasive tests. The main cause of treatment failure of H. pylori infection is its clarithromycin resistance. We recommend standard antibiotic susceptibility testing of H. pylori in pediatric patients prior to the initiation of eradication therapy. H. pylori treatment in children should be based on an evaluation of the rate of eradication in the local population, a systematic use of a treatment adapted to the susceptibility profile and a treatment compliance greater than 90%. The last meta-analysis in children did not show an advantage for sequential therapy when compared to a 14-day triple therapy. Finally, the high rate of antibiotic resistance responsible for therapy failure in recent years justifies the necessity of a novel vaccine to prevent H. pylori infection in children.

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Helicobacter pylori infection and its related factors in junior high school students in Nagano Prefecture, Japan

Abstract: The prevalence of H. pylori infection is as low as 3% among junior high school students aged 12-15 years in Japan. The disappearance of H. pylori is accelerating in Japanese children.

Cited by 28 publications

References 46 publications

Clinical features of Helicobacter pylori antibody‐positive junior high school students in Nagano Prefecture, Japan

Clinical features of Helicobacter pylori antibody‐positive junior high school students in Nagano Prefecture, Japan

Epidemiology of Helicobacter pylori infection

Helicobacter pylori infection in children

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