Helicobacter pylori infection and nonalcoholic fatty liver disease: Time for large clinical trials evaluating eradication therapy

Active Helicobacter pylori Infection is Independently Associated with Nonalcoholic Steatohepatitis in Morbidly Obese Patients

“…Nonalcoholic fatty liver disease (NAFLD), as the hepatic component of the metabolic syndrome (MetS), represents a leading cause of chronic liver disease; its estimated global prevalence is about 25% of the general population [1] whereas in morbidly obese individuals its prevalence might rise up to 90% [1,2]. NAFLD is bidirectionally linked to MetS and insulin resistance (IR) [3].…”

“…One of the potential pathogenetic "multiple hits, is regarded to be Helicobacter pylori infection (Hp-I) [1], with an estimated prevalence of 58% (varying from 39.9%-91.7%) worldwide [5]. Hp-I exhibits pleiotropic local and systematic manifestations.…”

“…Peptic ulcer, nonulcer dyspepsia, gastric adenocarcinoma, gastric mucosa-associated lymphoid tissue lymphoma, and colorectal cancer belong to its classical pathogenicity [6,7]. Beyond its established local pathologies, Hp-I has been associated with systematic entities, including MetS, IR, diabetes mellitus type 2 (T2DM), coronary artery disease, and neurodegenerative diseases [1,8]. In addition, there is accumulating evidence, that Hp-I might contribute to the development and progression of NAFLD, as concluded in several studies [9][10][11][12][13], although controversy still exists [14][15][16], as we have previously systematically reviewed [1].…”

“…Beyond its established local pathologies, Hp-I has been associated with systematic entities, including MetS, IR, diabetes mellitus type 2 (T2DM), coronary artery disease, and neurodegenerative diseases [1,8]. In addition, there is accumulating evidence, that Hp-I might contribute to the development and progression of NAFLD, as concluded in several studies [9][10][11][12][13], although controversy still exists [14][15][16], as we have previously systematically reviewed [1]. Notably, meta-analyses, having been conducted on the association between Hp-I and NAFLD, showed higher rates of NAFLD in Hp infected individuals, as we have also reviewed [5].…”

Doenças relacionadas à infecção pelo Helicobacter pylori

“…Durante muito tempo, discute-se a relação entre o Helicobacter pylori (HP) e a doença do refluxo gastresofágico (DRGE).Diversos estudos mostram não haver relação entre a presença de infecção do H. pylori e os sintomas de DRGE. No entanto, para além disso foi estudado não só a relação das duas patologias em si mas também a erradicação do HP e os sintomas de DRGE [12][13][14][15][16] .…”