<i>Helicobacter pylori</i> infection and normal colorectal mucosa–adenomatous polyp–adenocarcinoma sequence: a meta‐analysis of 27 case–control studies

Wang, F.; Sun, Manyi; Shi, Songli; Lv, Zhen

doi:10.1111/codi.12290

Cited by 36 publications

(28 citation statements)

References 43 publications

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“…However, whereas a previous study showed that duodenal ulcer was associated with decreased risk of gastric cancer [43], we found an increased risk for both gastric and duodenal ulcer patients. Our risk estimates for colon cancer were in agreement with studies reporting a modest increased risk of 20% [33]. The decreased risk of rectal cancer may reflect diagnosis of prevalent cancers during lower endoscopy following bleeding among patients with ulcer disease (vs. no screening in the general population).…”

Section: Discussionsupporting

confidence: 88%

“…The association with gastric adenocarcinoma appears to be restricted to increased risk of noncardia cancer [31]. In contrast, H. pylori infection is associated with an increased risk of colorectal cancer [9,[32][33][34]. Finally, evidence to support an association with other nongastric GI cancers is sparse, and null associations have been reported [8,[35][36][37][38][39][40].…”

Section: Discussionmentioning

confidence: 99%

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Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers

et al. 2016

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Peptic ulcer predicts gastric cancer. It is controversial if peptic ulcers predict other gastrointestinal cancers, potentially related to Helicobacter pylori or shared lifestyle factors. We hypothesized that gastric and duodenal ulcers may have different impact on the risk of gastrointestinal cancers. In a nationwide cohort study using Danish medical databases 1994–2013, we quantified the risk of gastric and other gastrointestinal cancers among patients with duodenal ulcers (dominantly H. pylori‐related) and gastric ulcers (dominantly lifestyle‐related) compared with the general population. We started follow‐up 1‐year after ulcer diagnosis to avoid detection bias and calculated absolute risks of cancer and standardized incidence ratios (SIRs). We identified 54,565 patients with gastric ulcers and 38,576 patients with duodenal ulcers. Patient characteristics were similar in the two cohorts. The 1–5‐year risk of any gastrointestinal cancer was slightly higher for gastric ulcers patients (2.1%) than for duodenal ulcers patients (2.0%), and SIRs were 1.38 (95% CI: 1.31–1.44) and 1.30 (95% CI: 1.23–1.37), respectively. The SIR of gastric cancer was higher among patients with gastric ulcer than duodenal ulcer (1.92 vs. 1.38), while the SIRs for other gastrointestinal cancers were similar (1.33 vs. 1.29). Compared with gastric ulcer patients, duodenal ulcer patients were at lower risk of smoking‐ and alcohol‐related gastrointestinal cancers. The risk of nongastric gastrointestinal cancers is increased both for patients with gastric ulcers and with duodenal ulcers, but absolute risks are low. H. pylori may be less important for the development of nongastric gastrointestinal cancer than hypothesized.

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Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 99%

Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers

et al. 2016

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“…These precancerous lesions occur in the following order: gastritis, atrophy, intestinal metaplasia (IM), and eventually dysplasia. H. pylori represent the most significant risk factor for gastric malignant tumors (Wang et al, 2014). Gastric cancer (GC) is an insidious disease, with symptoms that often manifest at an advanced stage, a time when the few remaining therapeutic options have low efficiency (Boreiri et al, 2013).…”

Section: H Pylori Adhesion and Invasion Mechanismmentioning

confidence: 99%

“…Gastric cancer (GC) is an insidious disease, with symptoms that often manifest at an advanced stage, a time when the few remaining therapeutic options have low efficiency (Boreiri et al, 2013). Approximately 10% of infected individuals develop severe gastric lesions, such as those in peptic ulcer disease; 1-3% progress to GC, with a low 5-year survival rate, and 0-1% develop mucosa-associated lymphoid tissue (MALT) lymphoma (Parreira et al, 2013;Wang et al, 2014).…”

Section: H Pylori Adhesion and Invasion Mechanismmentioning

confidence: 99%

Bacteriological Investigation of Helicobacter pylori Infections in Patients with Gastric and Duodenal Ulcer

Elshiekh¹,

Sultan²,

Zaky³

2017

Int.J.Curr.Microbiol.App.Sci

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“…Подобные результаты продемонстрированы и в другом метаана-лизе F. Wang и соавт. [35] с выявленной связью между патогенны-ми штаммами H. pylori (CagA+) и колоректальной аденокарцино-мой (ОШ 1,22 при 95% ДИ от 1,08 до 1,37; р=0,05). В настоящее время единственной, подтвержденной на экспериментальном уровне, является патогенетическая гипотеза о взаимосвязи ги-пергастринемии на фоне ассоциированного с H. pylori атрофиче-ского гастрита и повышения пролиферативной активности коло-ноцитов [36,37].…”

Section: терапевтический архив 8 2015unclassified

Helicobacter pylori infection and extragastroduodenal diseases

Маев¹,

Andreev²,

Kucheryavyi³

2015

Ter. arkh.

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АннотацияНа настоящее время достоверно определена клиническая значимость инфекции Helicobacter pylori в рамках развития целого ряда заболеваний гастродуоденальной зоны, включая хронический гастрит, язвенную болезнь желудка и двенад-цатиперстной кишки, MALT-лимфому, а также аденокарциному желудка. В консенсусе Маастрихт IV (2010 г.), определя-ющем международные стандарты диагностики и лечения инфекции H. pylori, экспертный совет постановил, что имеются доказательства возможной ассоциации инфекции H. pylori с развитием ряда экстрагастродуоденальных заболеваний (ЭГДЗ), представленных железодефицитной анемией неуточненной этиологии, идиопатической тромбоцитопенической пурпурой и дефицита витамина В 12 . При этих заболеваниях рекомендовано проведение диагностики инфекции H. pylori и при положительных результатах тестирования -эрадикация микроорганизма. За последнее время проведено большое количество исследований, посвященных изучению связи инфекции H. pylori и с другими ЭГДЗ. В настоящей статье приво-дится обзор теоретических и эпидемиологических данных ассоциации H. pylori с заболеваниями органов сердечно-сосу-дистой системы (атеросклероз, инфаркт миокарда), центральной нервной системы (болезнь Альцгеймера, болезнь Пар-кинсона), поджелудочной железы (аутоиммунный панкреатит, рак поджелудочной железы), онкологическими (аденомы толстой кишки, колоректальный рак, гепатоцеллюлярная карцинома), дерматологическими (хроническая спонтанная кра-пивница, псориаз) а также другими ЭГДЗ. В обзоре освещается потенциальная защитная роль H. pylori при заболеваниях с атопическим элементом генеза и осложненном течении гастроэзофагеальной рефлюксной болезни (пищевод Барретта, аденокарцинома пищевода). At present, the clinical significance of Helicobacter pylori infection has been validly determined within the development of a diversity of gastroduodenal diseases, including chronic gastritis, gastroduodenal ulcer, MALT lymphoma, and gastric adenocarcinoma. The Expert Council's Maastricht IV consensus (2010) determining international standards for the diagnosis and treatment of H. pylori infection is that there is evidence that the latter may be associated with the development of a number of extragastroduodenal diseases (EGDDs) presented by iron-deficiency anemia of unspecified etiology, idiopathic thrombocytopenic purpura, and vitamin B 12 deficiency. In these diseases, it is recommended that infection with H. pylori be diagnosed and, if the test is positive, this microorganism be eradicated. A large number of investigations have been recently conducted to examine the association of H. pylori infection with other EGDDs. This paper reviews theoretical and epidemiological data on the association of H. pylori with diseases of the cardiovascular (atherosclerosis, myocardial infarction) and central nervous (Alzheimer's disease, Parkinson's disease) systems, pancreas (autoimmune pancreatitis, pancreatic cancer), oncological (colonic adenomas, colorectal cancer, hepatocellular carcinoma), dermatological (chronic spontaneous urticaria), and ot...

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Helicobacter pylori infection and normal colorectal mucosa–adenomatous polyp–adenocarcinoma sequence: a meta‐analysis of 27 case–control studies

Abstract: The meta-analysis suggests a promoting effect of Helicobacter pylori on the risk of adenocarcinoma. It also suggests that Helicobacter infection might have its influence at the start of the adenomatous polyp disease sequence.

Cited by 36 publications

References 43 publications

Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers

Long‐term risk of gastrointestinal cancers in persons with gastric or duodenal ulcers

Bacteriological Investigation of Helicobacter pylori Infections in Patients with Gastric and Duodenal Ulcer

Helicobacter pylori infection and extragastroduodenal diseases

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