<i>Helicobacter pylori </i>infection and small intestinal bacterial overgrowth–more than what meets the eye

Dharan, Murali; Wozny, David R.

doi:10.12998/wjcc.v10.i21.7209

Cited by 3 publications

(3 citation statements)

References 31 publications

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“…Conversely, only 21.9% patients without H. pylori infection met the criteria for SIBO [ 103 ]. These data suggested that the incidence of SIBO was twice as high in patients infected with H. pylori compared to those uninfected patient [ 105 ]. This conclusion was further supported by a separate study conducted in 2018, which reported that 53% patients with concurrent H. pylori infection and SIBO were identified [ 106 ].…”

Section: H Pylori Infection In Pd Pathogenesismentioning

confidence: 99%

“…It is noteworthy that H. pylori infection causes mitochondria impairment, and the coexistence of H. pylori and damaged mitochondria synergistically contribute to the progression of SIBO [ 107 , 105 ] (Fig. 1 C).…”

Section: H Pylori Infection In Pd Pathogenesismentioning

confidence: 99%

“…Its virulence factor, VacA, can enter mitochondria and stimulate the release of cytochrome c from these organelles, further leading to mitochondrial impairment [ 104 , 108 , 109 ]. The emergence of SIBO further exacerbates mitochondrial dysfunction, and chronic infection at the large mucosal interface intensifies mitochondrial damage [ 107 , 105 ]. Impaired mitochondrial function impedes adenosine triphosphate (ATP) synthesis and calcium regulation, both of which are crucial for neuronal activity [ 110 , 111 ].…”

Section: H Pylori Infection In Pd Pathogenesismentioning

confidence: 99%

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Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability

Wei,

Zhao,

Cheng

et al. 2024

Immun Ageing

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Parkinson’s disease (PD), a neurodegenerative disorder with an unknown etiology, is primarily characterized by the degeneration of dopamine (DA) neurons. The prevalence of PD has experienced a significant surge in recent years. The unidentified etiology poses limitations to the development of effective therapeutic interventions for this condition. Helicobacter pylori (H. pylori) infection has affected approximately half of the global population. Mounting evidences suggest that H. pylori infection plays an important role in PD through various mechanisms. The autotoxin produced by H. pylori induces pro-inflammatory cytokines release, thereby facilitating the occurrence of central inflammation that leads to neuronal damage. Simultaneously, H. pylori disrupts the equilibrium of gastrointestinal microbiota with an overgrowth of bacteria in the small intestinal known as small intestinal bacterial overgrowth (SIBO). This dysbiosis of the gut flora influences the central nervous system (CNS) through microbiome-gut-brain axis. Moreover, SIBO hampers levodopa absorption and affects its therapeutic efficacy in the treatment of PD. Also, H. pylori promotes the production of defensins to regulate the permeability of the blood-brain barrier, facilitating the entry of harmful factors into the CNS. In addition, H. pylori has been found to induce gastroparesis, resulting in a prolonged transit time for levodopa to reach the small intestine. H. pylori may exploit levodopa to facilitate its own growth and proliferation, or it can inflict damage to the gastrointestinal mucosa, leading to gastrointestinal ulcers and impeding levodopa absorption. Here, this review focused on the role of H. pylori infection in PD from etiology, pathogenesis to levodopa bioavailability.

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Section: H Pylori Infection In Pd Pathogenesismentioning

confidence: 99%

Section: H Pylori Infection In Pd Pathogenesismentioning

confidence: 99%

Section: H Pylori Infection In Pd Pathogenesismentioning

confidence: 99%

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Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability

Wei,

Zhao,

Cheng

et al. 2024

Immun Ageing

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Influence of Helicobacter pylori Infection and Eradication on Small Intestinal Bacterial Overgrowth and Abdominal Symptoms

Wang,

Zhu,

et al. 2024

Dig Dis Sci

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Helicobacter pylori infection and small intestinal bacterial overgrowth: a systematic review and meta-analysis

Liao,

Su,

2023

BMC Microbiol

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Background There is a link between Helicobacter pylori (HP) infection and small intestinal bacterial overgrowth (SIBO) with nonspecific digestive symptoms. Nonetheless, whether HP infection is associated with SIBO in adults remains unclear. Based on a meta-analysis, we evaluated this relationship. Results Observational studies relevant to our research were identified by searching PubMed, Embase, the Cochrane Library, and the Web of Science. We evaluated between-study heterogeneity using the Cochrane Q test and estimated the I2 statistic. Random-effects models were used when significant heterogeneity was observed; otherwise, fixed-effects models were used. Ten datasets from eight studies, including 874 patients, were involved in the meta-analysis. It was shown that HP infection was related to a higher odds of SIBO (odds ratio [OR]: 1.82, 95% confidence interval: 1.29 to 2.58, p < 0.001) with mild heterogeneity (p for Cochrane Q test = 0.11, I2 = 7%). Subgroup analyses showed that HP infection was related to SIBO in young patients (mean age < 48 years, OR: 2.68, 95% CI: 1.67 to 4.28, p < 0.001; I2 = 15%) but not in older patients (mean age ≥ 48 years, OR: 1.15, 95% CI: 0.69 to 1.92, p < 0.60; I2 = 1%; p for subgroup difference = 0.02). Subgroup analyses further indicated that the association was not significantly affected by the country of study, comorbidities, exposure to proton pump inhibitors, or methods of evaluating HP infection and SIBO. Conclusions HP infection may be related to SIBO in adults, which supports the detection of SIBO in patients with digestive symptoms and HP infection.

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Helicobacter pylori infection and small intestinal bacterial overgrowth–more than what meets the eye

Cited by 3 publications

References 31 publications

Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability

Helicobacter pylori infection and Parkinson’s Disease: etiology, pathogenesis and levodopa bioavailability

Influence of Helicobacter pylori Infection and Eradication on Small Intestinal Bacterial Overgrowth and Abdominal Symptoms

Helicobacter pylori infection and small intestinal bacterial overgrowth: a systematic review and meta-analysis

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