Helicobacter pyloriInfection and the Risk of Gastric Carcinoma

Abstract

Infection with H. pylori is associated with an increased risk of gastric adenocarcinoma and may be a cofactor in the pathogenesis of this malignant condition.

Clinical Characteristics and Helicobacter pylori Status of Gastric Cancer in Thailand

“…Since Warren and Marshall first isolated H. pylori and found its association with gastritis (Warren et al, 1983), many studies have suggested the relationship between H. pylori infection and gastric cancer (Parsonnet et al, 1991, Uemura et al, 2001, Demirel et al, 2013, Karami et al, 2013. In this study, the prevalence of active and non-active H. pylori infection in gastric cancer was 40% and 43% respectively.…”

“…The annual incidence is 5 cases per 100,000 populations and had poor prognosis (Mahachai et al, 2011). Previous studies have suggested risk factors of gastric cancer included H. pylori infection, smoking, eating salty foods or fermented foods, family history of gastric cancer, gastric polyp and ethnic Japan, Chinese and Korean (Nomura et al, 1991;Parsonnet et al, 1991;Talley et al, 1991;Mahachai et al, 2011).…”

“…The pathogenesis of H. pylori in the development of gastric cancer has been suggested primarily from both epidemiological and basic research studies (Parsonnet et al, 1991, Uemura et al, 2001, Demirel et al, 2013, Karami et al, 2013, Basiri et al, 2014. The World Health Organization and International Agency for Research on Cancer consensus group stated in 1994 based on epidemiologic and histological evidence has classified H. pylori as a definite class I carcinogen (IARC 1994;Abeba et al, 2014).…”

Linking epithelial polarity and carcinogenesis by multitasking Helicobacter pylori virulence factor CagA

“…Gastric carcinoma is the second and fourth most common form of malignant tumors in male and female individuals, respectively, accounting for 876 000 estimated new cases and 405 000 estimated deaths in the year 2000 (Parkin et al, 2001). There is accumulating evidence that chronic infection with Helicobacter pylori, a spiral-shaped bacterium that colonizes the gastric mucosa of more than half of the world's human population, has a causative function in the development of gastric carcinoma (Nomura et al, 1991;Parsonnet et al, 1991;Uemura et al, 2001). Studies on H. pylori-gastric epithelial cell interactions have greatly contributed to our current understanding of H. pylori-triggered mucosal lesions that direct gastric carcinogenesis, pointing to the H. pylori virulence factor CagA (cytotoxin-associated gene A) as a central player in this process (Peek and Blaser, 2002;Hatakeyama, 2004Hatakeyama, , 2008.…”

H. pylori-associated pathologic findings among Alaska native patients

“…H. pylori is considered a group 1 carcinogen by the World Health Organization and populations with high H. pylori infection rates tend to have a higher risk for gastric cancer [4]. H. pylori infection typically progresses from gastritis and inflammation, to ulcers and eventually gastric cancer [5].…”