Helicobacter pylori infection and the prevalence of hypertension in Chinese adults: The Dongfeng‐Tongji cohort

Abstract

Although many studies explored the association between helicobacter pylori (H pylori) infection and hypertension, there is no consensus. This study is to investigate the association between H pylori infection and the prevalence of hypertension among a middle‐ and old‐age Chinese population. A cross‐sectional study including 17,100 participants from the Dongfeng‐Tongji cohort study was performed. All participants underwent a 14C‐urea breath test and a routine health check‐up. Logistics and linear regression with multivariable adjustment were used to quest the association between H pylori infection and hypertension. The individuals with H pylori infection had a higher prevalence of hypertension (57.5% vs 55.1%, P = .002), and infection rate of H pylori in patients with hypertension is higher than that in non‐hypertensive individuals (48.8% vs 46.4%, P = .002). After adjustment for potential confounders, H pylori infection increased the prevalence of hypertension (odds ratio, 1.117, 95% confidence interval (CI), 1.029‐1.213, P = .008). Moreover, compared with participants without H pylori infection, individuals infected had an increase of 0.905 mm Hg (95% CI, 0.025‐1.785, P = .044) for diastolic blood pressure. However, there was no interaction between H pylori infection and traditional risk factors on hypertension. These findings suggested that H pylori infection was positively associated with the prevalence of hypertension.

Predictors for regression and progression of intestinal metaplasia (IM): A large population-based study from low prevalence area of gastric cancer (IM-predictor trial)

“…pylori infection and hypertension in Chinese adults, which presumably resulted from atherosclerosis induced by H . pylori -related pro-inflammatory cytokines [ 22 ]. Lastly, the most important risk factor for the development of IM was current H .…”

Preliminary single‐center experience of Helicobacter pylori eradication among the liver transplant recipients

“…Considering the immunocompromised status after transplantation and the high prevalence of H. pylori infection among the general population in China (50%), the risk of H. pylori recurrence among LT recipients may be significantly elevated compared with the general population. In addition, a significant proportion of LT recipients have metabolic syndrome, which may also increase the likelihood of H. pylori re‐infection 22,23 . Therefore, screening and treating infected family members and improving sanitary conditions are recommended to reduce the risk of H. pylori recurrence in LT recipients.…”

“…In addition, a significant proportion of LT recipients have metabolic syndrome, which may also increase the likelihood of H. pylori re-infection. 22,23 Therefore, screening and treating infected family members and improving sanitary conditions are recommended to reduce the risk of H. pylori recurrence in LT recipients.…”

Helicobacter pylori Infection and Endothelial Dysfunction

“…After adjusting for traditional CVD risk factors, H. pylori infection is found to be the only independent predictor of incident carotid plaque with the multivariate odds ratio (OR) of 2.3, and incident acute stroke (with multivariate OR of 3.6) [31]. H. pylori infection was positively associated with the prevalence of HTN among Chinese adults [25,26].…”

“…A recent meta-analysis with a large population showed that H. pylori infection increased the risk of adverse cardiovascular events by 51%, mostly due to myocardial infarction and cerebrovascular disease [23]. Data also suggests that H. pylori infection increases the risk of coronary heart diseases (CHD) and related events predominantly in a patient's early life [24], and is positively associated with HTN [25,26]. In this chapter, efforts will be focused on: 1) brief overview on the association of H. pylori infection and CVDs; 2) relationship between H. pylori infection and atherosclerosis; 3) H. pylori infection and endothelial dysfunction; 4) role of exosomes in mediating the effect of H. pylori infection on endothelial function, and 5) significance and clinical implications.…”