Helicobacter pylori Infection following Endoscopic Resection of Early Gastric Cancer

Abstract

e role of Helicobacter pylori (H. pylori) infection in patients following endoscopic resection of early gastric cancer (EGC) remains unclear. is article presents a review of literature published in the past 15 years. H. pylori-mediated persistent methylation levels are associated with the development of metachronous gastric cancer. e methylation of certain speci c genes can be used to identify patients with a high risk of metachronous gastric cancer even a er H. pylori eradication. H. pylori eradication a er endoscopic resection should be performed as early as possible for eradication success and prevention of metachronous precancerous lesions. Although whether the eradication of H. pylori could prevent the development of metachronous cancer a er endoscopic resection is controversial, several meta-analyses concluded that H. pylori eradication could reduce the incidence of metachronous gastric cancer signi cantly. In addition, H. pylori eradication in gastric cancer survivors a er endoscopic resection could reduce healthcare cost and save lives in a cost-e ective way. Taken together, H. pylori eradication a er endoscopic resection of EGC is recommended as prevention for metachronous precancerous lesions and metachronous gastric cancer.

Clinical Relevance of Helicobacter pylori Infection

“…Patients with precancerous lesions who do not reverse after treatment with H. pylori are at the 'point of no return' and may be at high risk of developing stomach cancer. An earlier eradication of H. pylori should prevent the development of gastric cancer before the onset of precancerous lesions [24,25].…”

Clinical and Endoscopic Features in Helicobacter Pylori Infection: Literature Review

“…8,29 Colonization of H.pylori bacteria is the most significant and important risk factor for gastric malignancy development. 29,59,60 Gastric adenocarcinoma can be classified into intestinal-type and diffuse-type. 15,61 Intestinal-type adenocarcinoma is more common, has been well studied, and H.pylori infection can cause chronic gastritis, atrophy, intestinal metaplasia, dysplasia, and cause intestinal-type gastric cancer.…”

“…15,61 Intestinal-type adenocarcinoma is more common, has been well studied, and H.pylori infection can cause chronic gastritis, atrophy, intestinal metaplasia, dysplasia, and cause intestinal-type gastric cancer. 8,15,60,61 However, gastric malignancies development depends on H.pylori virulence factors, genetic hosts, dietary factors, micronutrients, and gastrointestinal microbiota. 14 H.pylori bacteria, which carry the cagA gene, cause more severe inflammation, and the disease can progress to atrophic gastritis and malignancy.…”

Scutellarin Inhibits the Growth and EMT of Gastric Cancer Cells through Regulating PTEN/PI3K Pathway

“…Gastric cancer is one of the most frequent and fatal malignancies in human beings, which seriously affect the patients' lives. 1) The occurrence of gastric cancer is related to smoking, alcohol abuse and Helicobacter pylori infection. 2) Clinically, about 20% of gastric cancer patients die within five years after diagnosis, mainly due to high lymphatic metastasis, recurrence and drug resistance.…”