<i>Helicobacter pylori</i>Infection in Finnish Children and Adolescents A Serologic Cross-Sectional and Follow-up Study

Ashorn, Merja; Mäki, Markku; Hällström, Minna; Uhari, Matti; Åkerblom, H. K.; Viikari, Jorma; Miettinen, Aaro

doi:10.3109/00365529509101594

Cited by 83 publications

(55 citation statements)

References 16 publications

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“…The prevalence of infection was greater in boys than in girls. In addition, spontaneous elimination of the helicobacter infection from children has also been reported previously in developed countries [29,30]. No sex differences in those low-risk populations have been reported.…”

Section: Discussionmentioning

confidence: 69%

Delayed rise in incidence of gastric cancer in females results in unique sex ratio (M/F) pattern: etiologic hypothesis

2002

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Conclusion.The male predominance of GCA is a global phenomenon, and is similar in populations with high and low GCA incidence, and this predominance is related to a 10-to 15-year delay in the appearance and onset of GCA of the intestinal subtype in females compared with males. It is suggested that sex hormones (estrogens) protect women against GCA, and that GCA begins to be as prevalent in females as in males only after the menopausal age. Another possibility is that a later acquisition of H. pylori gastritis in females than in males causes the relative delay in the appearance and onset of new GCA cases in females compared with males.

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Section: Discussionmentioning

confidence: 69%

Delayed rise in incidence of gastric cancer in females results in unique sex ratio (M/F) pattern: etiologic hypothesis

2002

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“…This, along with the absence of a fixed hot water supply, had been considered a strong risk factor for infection 26 . In contrast, studies which could be seen to reflect good hygienic conditions and less crowded environments reported a much lower prevalence; less than 6 or 7% in a study carried out on 3300 German children 27 , with comparable values reported from other European countries [28][29][30] . In more recent times however, acquisition away from the home has been considered more important.…”

Section: Discussionmentioning

confidence: 81%

Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth

Mohammad¹,

Hussein²,

Coward

et al. 2008

Public Health Nutr.

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Objective: The study aim was to assess the prevalence of Helicobacter pylori infection in Egyptian schoolchildren and its effect on growth parameters. Design: A cross-sectional population-based study was conducted among 286 schoolchildren (168 boys and 118 girls), with a mean age of 11.04 6 0.19 years, to determine the prevalence of H. pylori. The presence of the bacterium was assessed using the [ 13 C]urea breath test. Relevant personal and socio-economic data on risk factors for infection were collected. Height and weight were analysed in relation to H. pylori infection. Results: The overall prevalence of H. pylori infection was 72.38%. Attending school in a socially deprived area and residing in an overcrowded home were the major risk factors for infection. Differences between infected and non-infected children were significant with regard to body weight and height (weight: 39.5 6 1.0 vs. 44.6 6 1.8 kg, P 5 0.05; height: 139.9 6 1.3 vs. 144.2 6 2.1 cm; P 5 0.009). The number of children (both boys and girls) falling below the 5th percentile of height-for-age was significantly higher in infected than non-infected children (P 5 001), similarly for Z-scores for height-for-age below -2.0 (P 5 0.003). Conclusion:The results demonstrate not only that the prevalence of H. pylori infection is extremely high among Egyptian schoolchildren, but also that the adverse effects of the infection reach far beyond the stomach. Evidence of the burden of infection on growth failure is presented.

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“…Ashorn et al (3) found that only one infant out of 21 who had transplacental H. pylori IgG antibodies remained seropositive throughout the follow-up period, and no new seroconversions occurred in the remaining 20 infants. On the contrary, they found ten originally cord-blood negative children seroconverted up to the age of 2 years (5.1%).…”

Section: Discussionmentioning

confidence: 99%

Five-Year Follow-Up Study of Mother-to-Child Transmission ofHelicobacter pyloriInfection Detected by a Random Amplified Polymorphic DNA Fingerprinting Method

et al. 2005

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Recent studies have speculated on the possible role of the mother in transmitting Helicobacter pylori infection to their children. In an attempt to either prove or disprove this supposition, we investigated the rates of infection of children born to H. pylori-positive mothers from birth to 5 years of age using serology and the stool antigen test. When infection of the children did occur, the strains from the children were compared to those of their mothers using DNA analysis. Sixty-nine of the 350 pregnant mothers (19.7%) had a positive serology for H. pylori. Fifty-one children underwent serological examinations and stool antigen tests at 4 to 6 days after birth, followed by 1, 3, and 6 months. They were continuously given the stool antigen test at 4-to 6-month intervals until the age of 5 years. Gastric juice samples were collected from the infected children and their mothers for culture and DNA analyses using a random amplified polymorphic DNA fingerprinting method. None of the 51 children acquired H. pylori infection during the first year of life. Of the 44 children enrolled in a 5-year follow-up study, five (11%) acquired H. pylori infection. They acquired the infection at the age of 1 year 2 months, 1 year 3 months, 1 year 6 months, 1 year 8 months, and 4 years 4 months. Random amplified polymorphic DNA fingerprinting confirmed that the strains of the five children exhibited DNA fingerprinting patterns identical to those of their mothers. These findings suggest that mother-to-child transmission is the most probable cause of intrafamilial spread of H. pylori.

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Helicobacter pyloriInfection in Finnish Children and Adolescents A Serologic Cross-Sectional and Follow-up Study

Abstract: In children seropositivity for H. pylori of the IgG class is often a sign of an infection acquired in early childhood. It seems likely that the age-dependent increase in the seropositivity reflects cumulation of a chronic infection.

Cited by 83 publications

References 16 publications

Delayed rise in incidence of gastric cancer in females results in unique sex ratio (M/F) pattern: etiologic hypothesis

Delayed rise in incidence of gastric cancer in females results in unique sex ratio (M/F) pattern: etiologic hypothesis

Prevalence of Helicobacter pylori infection among Egyptian children: impact of social background and effect on growth

Five-Year Follow-Up Study of Mother-to-Child Transmission ofHelicobacter pyloriInfection Detected by a Random Amplified Polymorphic DNA Fingerprinting Method

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