<i>Helicobacter pylori</i> Infection in Pediatrics

Veres, Gábor; Pehlivanoğlu, Ender

doi:10.1111/j.1523-5378.2007.00532.x

Cited by 18 publications

(9 citation statements)

References 66 publications

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“…Our experience of the use of noninvasive tests confirms that of previous publications reporting the high sensitivity and specificity of UBT , whether employed before treatment to confirm or exclude infection or used to confirm HP eradication. In contrast, the sensitivity of SAIT in this study was very low and completely different from that reported in other studies .…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection in Children. Antimicrobial Resistance and Treatment Response

Montes

F²,

Eizaguirre

et al. 2014

Helicobacter

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Section: Discussionmentioning

confidence: 99%

Helicobacter pylori Infection in Children. Antimicrobial Resistance and Treatment Response

Montes

F²,

Eizaguirre

et al. 2014

Helicobacter

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“…Çocukluk çağının, H. pylori enfeksiyonunun edinilmesinde önem-li bir dönemi oluşturduğu gösterilmiştir (4). Özellikle KKA olan çocuklarda %20'lerde H. pylori pozitifliği bildirilmiş olmakla birlikte, bu pozitifliğin hastalık gidişini etkilemediği saptanmıştır.…”

Section: Introductionunclassified

Coexistence of Helicobacter pylori and Intestinal Parasitosis in Children with Chronic Abdominal Pain

Gökşen¹,

Appak²,

Girginkardeşler³

et al. 2016

TurkiyeParazitolDerg

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ÖZAmaç: Bu çalışmanın amacı kronik karın ağrısı (KKA) yakınması ile başvuran çocuklarda Helicobacter pylori (H. pylori) enfeksiyonu ve bağırsak parazitozları birlikteliğinin sıklığı ve her iki enfeksiyonun oluşmasındaki ortak risk etmenlerinin belirlenmesidir. Yöntemler: KKA yakınması ile başvuran 90 hasta çalışmaya alınmıştır. Tüm olguların kan örnekleri H. pylori Ig G (HpIgG) antikoru ve dışkı örnekleri ise H. pylori antijeni (H. pylori stool antigen-HpSA) ve direkt bakı, ayrıca formol-etil asetat konsantrasyon ve Trikrom boyama yön-temleriyle bağırsak parazitleri yönünden incelenmiştir. Enterobius vermicularis (E. vermicularis) için anal bant testi uygulanmıştır. HpIgG ve/ veya HpSA pozitif saptanan çocuklar H. pylori pozitif kabul edilmiştir. Risk etkenleri anket çalışması ile karşılaştırılmıştır. Bulgular: Giardia intestinalis (G. intestinalis) insidansının H. pylori pozitif grupta %14,8 olduğu ve H. pylori negatif grup ile karşılaştırıldığın-da (%1,6) istatistiksel olarak yüksek olduğu belirlenmiştir. H. pylori pozitiflik oranının okula giden ve içme suyu olarak şebeke suyu kullanan çocuklarda anlamlı düzeyde arttığı saptanmıştır. Anne eğitim düzeyi düşük olan ve ailede parazit tedavisi alma öyküsü bulunan çocuklarda parazitoz insidansı anlamlı düzeyde yüksek bulunmuştur. Sonuç: H. pylori enfeksiyonu ve bağırsak parazitozları çocuklarda kronik karın ağrısı etiyolojisinin en sık nedenlerindendir. Hijyen koşullarının iyileştirilmesi her iki enfeksiyonun önlenmesinde yararlı olabilir (Turkiye Parazitol Derg 2016; 40: 32-6 ABSTRACT Objective: The aim of this study was to determine the incidence of coinfection with Helicobacter pylori and intestinal parasitosis in children with chronic abdominal pain (CAP) and to investigate the common risk factors in the development of both infections. Methods: Ninety patients with CAP were enrolled in this study. Blood samples of each case were screened for human preformed IgG (HpIgG) antibodies, and stool samples were tested for HpSA and also examined for intestinal parasites by direct wet-mount, formalin-ethyl-acetate concentration, and Trichrome staining procedures. Cellophane tape test was used for Enterobius vermicularis. Children tested positive for HpIgG and/or HpSA were accepted as H. pylori positive. The risk factors were compared with a questionnaire.Results: The incidence of Giardia intestinalis was 14.8% in the H. pylori-positive group and was found to be statistically higher than that in the H. pylori-negative group (1.6%). The positivity rates of H. pylori were found to be statistically higher in children attending school and using drinking water from taps. The incidences of parasitosis were significantly higher in children with a low maternal education level and with a history of parasitosis treatment in the family. Conclusion:The most common etiologies of CAP in children are H. pylori infection and intestinal parasitosis. İmprovement of hygienic conditions would be beneficial in preventing both infections. (Turkiye Parazitol Derg 2016; 40: 32-6).

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“…On one hand, this could result in enhancing the progression to cancer through premalignant lesions; while, on the other hand, cytokines may be responsible for better capabilities to clear H. pylori infection after acquiring the microorganism. There is evidence showing that a proportion of individuals spontaneously clear the infection [32]. In a pediatric study in Jamaica, it was found that the presence of the IL-1A-889 T allele was associated with a lower risk of H. pylori infection (with 43% risk reduction) [33].…”

Section: Host Geneticsmentioning

confidence: 99%

Markers for Gastric Cancer Premalignant Lesions: Where Do We Go?

Leja

Wex²,

Malfertheiner³

2012

Dig Dis

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Only a small proportion of patients infected with Helicobacter pylori develop gastric cancer during their lifetime. At the same time, this type of cancer remains an important cause of mortality globally. The current interventional strategies have not been successful in decreasing the global burden of the disease; therefore, biomarkers for the identification of the individuals at high risk as well as those in the early stage of the disease is of high importance. In addition, predicting the point of no return for the development of the malignancy is of particular interest; whether atrophy, intestinal or spasmolytic polypeptide-expressing metaplasia, or some of their subtypes correspond to this point, still needs to be answered. The current review addresses the place of ‘old markers’, in particular pepsinogen tests for the identification of increased risk conditions. More data in Caucasian populations are required before these tests can be recommended for routine screening. Several of the host genetic factors are related to the development of sporadic gastric cancer; still their importance is probably not so high as initially thought, and at this stage host genetic factors cannot be used to identify high-risk groups. The detection of specific microRNAs could become a potential field in marker development, and several other new approaches for marker identification are emerging. To achieve the goal, a screening marker has to be not only accurate, but also available and cost-effective in the target populations, many of which are from low-income countries. This has to be considered when developing a marker or set of markers offered for gastric cancer screening programs.

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Helicobacter pylori Infection in Pediatrics

Cited by 18 publications

References 66 publications

Helicobacter pylori Infection in Children. Antimicrobial Resistance and Treatment Response

Helicobacter pylori Infection in Children. Antimicrobial Resistance and Treatment Response

Coexistence of Helicobacter pylori and Intestinal Parasitosis in Children with Chronic Abdominal Pain

Markers for Gastric Cancer Premalignant Lesions: Where Do We Go?

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