<i>Helicobacter pylori</i> infection in subjects negative for high titer serum antibody

Toyoshima, Osamu; Nishizawa, Toshihiro; Arita, Masahide; Kataoka, Yasufumi; Sakitani, Kosuke; Yoshida, Shuntaro; Yamashita, Hiroharu; Hata, Keisuke; Watanabe, Hidenobu; Suzuki, Hidekazu

doi:10.3748/wjg.v24.i13.1419

Cited by 47 publications

(63 citation statements)

References 38 publications

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“…When the serum anti-H. pylori antibody titer was ≥ 3.0 U/mL, the urea breath test or histology was added. If either the urea breath test or histology was positive, patients were considered positive for H. pylori [18,19]. An antibody titer < 3.0 U/mL or negative urea breath test was considered to indicate H. pylori negativity.…”

Section: Diagnosis Of H Pylori Infectionmentioning

confidence: 99%

Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection

Toyoshima

Nishizawa

Sakitani³

et al. 2020

Endosc Int Open

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Background and study aims Helicobacter pylori-associated nodular gastritis, which is associated with follicular lymphoid hyperplasia, is mainly recognized in the antrum. However, we have also observed nodularity-like appearance in the cardia. This study aimed to investigate the clinical signiﬁcance of cardiac nodularity-like appearance in H. pylori-associated gastritis. Patients and methods Patients who underwent esophagogastroduodenoscopy and were evaluated for H. pylori infection for the ﬁrst time were enrolled. A nodularity-like appearance in the cardia was defined as a miliary nodular appearance or scattered appearances of small circular whitish coloration. H. pylori infection was diagnosed according to serum anti-H. pylori antibody and the urea breath test or histology. Accuracy of the H. pylori infection diagnoses based on nodularity-like appearance were assessed. Results Among 265 patients, 42 patients (15.8 %) were diagnosed as positive for H. pylori. Cardiac nodularity-like appearance and antral nodularity were recognized in 25 and 15 patients, respectively. In accuracy of predicting H. pylori by cardiac nodularity-like appearance, specificity was 0.996, sensitivity was 0.571, positive predictive value was 0.960, negative predictive value was 0.925, and accuracy was 0.928. The sensitivity of cardiac nodularity-like appearance was significantly higher than that of antral nodularity (P = 0.0284). Conclusions Cardiac nodularity-like appearance had a high accuracy rate for H. pylori infection diagnosis. Cardiac nodularity-like appearance was found more frequently than antral nodularity.

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Section: Diagnosis Of H Pylori Infectionmentioning

confidence: 99%

Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection

Toyoshima

Nishizawa

Sakitani³

et al. 2020

Endosc Int Open

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“…The Kyoto classification score comprises parameters such as atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness. The Kyoto classification score was reportedly associated with the risk of H. pylori infection and gastric cancer 15,[22][23][24][25] ; however, the change in Kyoto score before and Clinic on 6 September 2019 (approval no. S1909-U06).…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylorieradication improved the Kyoto classification score on endoscopy

et al. 2020

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Background and Aim: Endoscopy-based Kyoto classification predicts the risk of Helicobacter pylori infection and gastric cancer; however, the change in score following H. pylori eradication remains unknown. We retrospectively compared the Kyoto score before and after H. pylori eradication. Methods: H. pylori-positive patients who underwent baseline esophagogastroduodenoscopy (EGD), successful H. pylori eradication, and surveillance EGD were enrolled. The Kyoto score is a sum of scores for atrophy (Kimura-Takemoto atrophicborder classification none or C1: 0, C-II or C-III: 1

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“…The serum antibody titer was measured by an enzyme-linked immunoassay kit using antigens derived from Japanese individuals: E-plate Eiken H. pylori antibody II kit (Eiken Chemical, Tokyo, Japan). We defined a cut-off value of 10 U/mL was identified for H. pylori positivity as the manufacturer recommended[ 13 - 15 ].…”

Section: Methodsmentioning

confidence: 99%

“…The Kyoto classification score consisted of scores in gastric atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness[ 12 ]. Several studies have revealed the association of the Kyoto score with H. pylori infection[ 13 - 17 ] and gastric cancer risk[ 18 - 20 ]; however, the consistency of the Kyoto score with pathological findings has not been clarified. Therefore, this study aimed to investigate the relationship between the Kyoto score and pathological findings.…”

Section: Introductionmentioning

confidence: 99%

Endoscopy-based Kyoto classification score of gastritis related to pathological topography of neutrophil activity

Toyoshima¹,

Nishizawa²,

Yoshida³

et al. 2020

WJG

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BACKGROUND Endoscopy-based Kyoto classification for gastritis and pathological topographic distribution of neutrophil infiltration are correlated with gastric cancer risk. AIM To investigate the association between Kyoto classification and the topographic distribution of neutrophil activity. METHODS Kyoto classification score, ranging from 0 to 8, consisted of atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness. Neutrophil activity was scored according to the updated Sydney System using biopsy samples obtained from the greater curvature of the corpus and the antrum. The participants were divided into four categories, inactive stomach, antrum-predominant gastritis, pangastritis, and corpus-predominant gastritis, based on the topographic distribution of neutrophil activity. Effects of sex, age, body mass index, drinking habit, smoking habit, family history of gastric cancer, serum Helicobacter pylori ( H. pylori ) antibody, and Kyoto score on topography of neutrophil infiltration were analyzed. RESULTS A total of 327 patients (comprising 50.7% women, with an average age of 50.2 years) were enrolled in this study. H. pylori infection rate was 82.9% with a mean Kyoto score of 4.63. The Kyoto score was associated with the topographic distribution of neutrophil activity. Kyoto scores were significantly higher in the order of inactive stomach, antrum-predominant gastritis, pangastritis, and corpus-predominant gastritis (3.05, 4.57, 5.21, and 5.96, respectively). Each individual score of endoscopic findings ( i.e ., atrophy, intestinal metaplasia, enlarged folds, nodularity, and diffuse redness) was correlated with the topographic distribution of neutrophil activity. On multivariate analysis, the Kyoto score, age, and serum H. pylori antibody were independently associated with the topographic distribution of neutrophil activity. CONCLUSION The Kyoto classification score was associated with the topographic distribution of neutrophil activity.

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Helicobacter pylori infection in subjects negative for high titer serum antibody

Cited by 47 publications

References 38 publications

Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection

Nodularity-like appearance in the cardia: novel endoscopic findings for Helicobacter pylori infection

Helicobacter pylorieradication improved the Kyoto classification score on endoscopy

Endoscopy-based Kyoto classification score of gastritis related to pathological topography of neutrophil activity

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