<i>Helicobacter pylori</i> Infection in Turkish Children: Comparison of Diagnostic Tests, Evaluation of Eradication Rate, and Changes in Symptoms after Eradication

Özçay, Figen; Koçak, Nurten; Saltık-Temizel, İnci Nur; Demır, Hülya; Özen, Hasan; Yüce, Aysel; Gürakan, Figen

doi:10.1111/j.1083-4389.2004.00230.x

Cited by 54 publications

(54 citation statements)

References 40 publications

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“…The most commonly tested regimen contained a combination of PPI, clarithromycin, and amoxicillin, followed by triple therapies containing PPI, clarithromycin, and nitroimidazoles, or bismuth, clarithromycin, and nitroimidazoles (3)(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). The reasons for the great variability of the eradication rates observed in the studies include small sizes of study populations, differences between study populations, and variation in the total daily dose, dosing frequency and duration of treatment components, as well as in time of posttreatment follow-up and methods used to assess eradication after treatment.…”

Section: Resultsmentioning

confidence: 99%

“…In addition, this method provides no information on dose timing, which may be important in determining clinical outcomes. In other pediatric studies indirect methods of measurement of adherence included questioning the patient (or using a questionnaire) (4,7,15), but questioning the patient can be susceptible to misrepresentation and tends to result in the physician's overestimating the patient's adherence. This underscores the thought that the body of knowledge on children's adherence to medication regimens (or placebo) for H. pylori eradication is inadequate in many respects and has not quantified the true effect of nonadherence on the failure rates of various medication regimens.…”

Section: Factors Affecting Eradication Ratementioning

confidence: 99%

“…The very limited experience in children with a quadruple regimen containing tetracyclines has yielded discrepant results. in terms of eradication rates (15,27). Furthermore, there is reluctance on the part of pediatricians to prescribe the tetracycline group of antibiotics.…”

Section: Re-treatmentmentioning

confidence: 99%

See 2 more Smart Citations

Helicobacter Pylori Therapy in Children: Overview and Challenges

Chiesa

Pacifico

Anania

et al. 2010

Int J Immunopathol Pharmacol

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Helicobacter pylori is one of the most common infections found in humans. It was first identified in 1982 and by 1989 had been associated with gastric inflammation and ulcers in adults and children. During the 1990's evidence emerged of its etiologic role in stomach cancers in adults. That the infection is common and may have serious consequences, has led to an avalanche of research during the last twenty years. During this time, there have been many studies on children which have sought an effective and safe treatment to eradicate the infection, but as yet, no therapy regimen has been found which is always effective and safe. This article provides information, from a pediatric point of view, on the major developments in the therapeutics and therapy of H. pylori infection. It examines first-line treatment regimens, evaluates the efficacy of the main drugs used in the management of (primary) H. pylori infection in children, assesses the potential for the use of probiotics and sequential therapy, examines therapeutic options after failure of initial treatment, and discusses factors affecting eradication rate, including antibiotic resistance, adherence to therapy, and bacterial factors.

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Section: Resultsmentioning

confidence: 99%

Section: Factors Affecting Eradication Ratementioning

confidence: 99%

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Helicobacter Pylori Therapy in Children: Overview and Challenges

Chiesa

Pacifico

Anania

et al. 2010

Int J Immunopathol Pharmacol

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“…In a study made on 102 dyspeptic children in Turkey recently (29), sensitivity of only 71.9% was found for serology. Differently from these findings, in another study involving 180 children (15), 100% sensitivity and 98% specificity were found (30).…”

Section: Discussionmentioning

confidence: 96%

Comparison of antigen and antibody detection tests used for diagnosing the Helicobacter pylori infection in symptomatic patients

Alim

Ataş²,

Güneş³

et al. 2013

Basic Clin Sci

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Helicobacter pylori (H. pylori) infection is usually acquired in early childhood. H. pylori infection can be diagnosed by noninvasive techniques (serology, urea breath test, urine or blood, detection of H. pylori antigen in stool specimen) and by invasive techniques requiring endoscopy and biopsy (histological examination, culture, polymerase chain reaction). Recently, fecal antigen testing has been used successfully for the diagnosis of H. pylori infection in the Symptomatic Patients. We compared H. pylori fecal antigen and immunoglobulin G (IgG) serologic diagnostic methods in a population of symptomatic patients with H. pylori infection. The tests were performed with enzyme immunoassay (ELISA). All specimens were collected between January and October 2009 from 27 health center in Sivas-Turkey. The presence of clinical symptoms, such as dyspepsia and abdominal pain, was determined. A total of 705 patients were studied. Totally, 534 women (mean age 38.2) and 171 men (mean age 41.9) in this epidemiological investigation were enrolled. The H. pylori fecal antigen was positive in the stool specimens of 209 patients (29.6%) and the H. pylori IgG test was positive in the serum specimens of 487 (69.0%) patients. The fecoprevalance and seroprevalence of H. pylori infection were higher in women than in men (p < 0.05). ELISA fecal antigen testing is a practical and feasible alternative to traditional invasive diagnostic methods in highprevalence populations. The fecal antigen test can also be used to establish cure of H. pylori infection.

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“…In particular, clarithromycin and metronidazole resistances have some regional differences (1,3). In Turkey, metronidazole resistance has the highest frequency (36.4%) in children, followed by clarithromycin resistance (18.2%-25.7%) (4,5). A 10-year epidemiological analysis (1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005) in the Turkish population reported a gradual decrease in eradication success from 80% to 60% while using a PPI, amoxicillin, and clarithromycin (6).…”

Section: Introductionmentioning

confidence: 99%

Comparison of standard and standard plus vitamin E therapy for Helicobacter pylori eradications in children

Tümgör

Baran²,

Çakır³

et al. 2015

Turk J Gastroenterol

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Background/Aims: Although various drugs can be used in adults for Helicobacter pylori eradication in adults, treatment options are limited in children. The aim of this study was to compare the effects of the standard lansoprazole, amoxicillin, and clarithromycin (LAC) protocol to those of LAC + vitamin E (LACE) combination for H. pylori eradication. Materials and Methods: The study included 90 children (age range: 10-17 years) who were admitted to four pediatric gastroenterology centers between March 2011 and November 2012 with dyspeptic symptoms and who had tested positive for H. pylori by 14C-urea breath tests. The patients were randomized into two groups. The LAC group [45 patients (pts)] was treated with a standard regimen consisting of lansoprazole (1 mg/kg/day), amoxicillin (50 mg/kg/ day), and clarithromycin (14 mg/kg/day), each of which was given in two equally divided doses every 12 h for 14 days; the LACE group (45 pts) was given the standard regimen and vitamin E at 200 IU/day for 14 days. H. pylori eradication was assessed using the 14C-UBT in the 6th week after the cessation of treatment. Results: H. pylori was eradicated in 21 (46.6%) pts in the LAC group, while it was eradicated in 29 (64.4%) pts in the LACE group. There was no statistical difference between the two groups (p=0.13). Conclusion: The eradication rate of H. pylori in children while using the LAC regimen has decreased in the last years. The LACE regimen has been associated with an increased eradication rate but can reach to statistically significance. Further studies with larger cohorts are needed to examine the success of the LACE regimen for H. pylori eradication.

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Helicobacter pylori Infection in Turkish Children: Comparison of Diagnostic Tests, Evaluation of Eradication Rate, and Changes in Symptoms after Eradication

Cited by 54 publications

References 40 publications

Helicobacter Pylori Therapy in Children: Overview and Challenges

Helicobacter Pylori Therapy in Children: Overview and Challenges

Comparison of antigen and antibody detection tests used for diagnosing the Helicobacter pylori infection in symptomatic patients

Comparison of standard and standard plus vitamin E therapy for Helicobacter pylori eradications in children

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