<i>Helicobacter pylori</i> infection in two areas in Japan with different risks for gastric cancer

Nobuta, Aichiro; Asaka, Masahiro; Sugiyama, Toshiro; Kato, Mototsugu; Hige, S; Takeda, Hiroshi; Kato, Toshiyuki; Ogoshi, Kazuei; Keida, Yoshihide; Shinomura, J.

doi:10.1111/j.1365-2036.2004.01976.x

Cited by 18 publications

(12 citation statements)

References 30 publications

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“…The titer of CagA antibody in patients with gastric cancer was higher than that in people without gastric cancer; similarly, the titer of CagA antibody in high-risk populations was significantly higher than that in low-risk populations (Zhang et al, 1998). Compared with CagA-negative H. pylori strains, CagA-positive strains dramatically increased the occurrence of severe gastritis and gastric adenocarcinoma (Tokieda et al, 1999;Enroth et al, 2000;Held et al, 2004;Nobuta et al, 2004). These studies indicate that CagA may play an important role in the development of gastric cancer.…”

Section: Introductionmentioning

confidence: 69%

Transformed immortalized gastric epithelial cells by virulence factor CagA of Helicobacter pylori through Erk mitogen-activated protein kinase pathway

et al. 2005

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Section: Introductionmentioning

confidence: 69%

Transformed immortalized gastric epithelial cells by virulence factor CagA of Helicobacter pylori through Erk mitogen-activated protein kinase pathway

et al. 2005

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“…Interestingly, the incidence of gastric cancer in Okinawa (6.3 deaths/100,000 population) is the lowest in Japan (access in 2010a), although the prevalence of H. pylori in this area is not significantly different from that in other parts of Japan (Ito et al, 1996; Nobuta et al, 2004). The low prevalence of gastric cancer in Okinawa is comparable to that of the U.S. (4.1/100,000) (access in 2010b).…”

Section: Virulence Factorsmentioning

confidence: 92%

Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori

Suzuki

Shiota

Yamaoka

2012

Infection, Genetics and Evolution

131

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Helicobacter pylori infection is linked to various gastroduodenal diseases; however, only approximately 20% of infected individuals develop severe diseases. Despite the high prevalence of H. pylori infection in Africa and South Asia, the incidence of gastric cancer in these areas is much lower than in other countries. Furthermore, the incidence of gastric cancer tends to decrease from north to south in East Asia. Such geographic differences in the pathology can be explained, at least in part, by the presence of different types of H. pylori virulence factors, especially cagA, vacA, and the right end of the cag pathogenicity island. The genotype of the virulence genes is also useful as a tool to track human migration utilizing the high genetic diversity and frequent recombination between different H. pylori strains. Multilocus sequence typing (MLST) analysis using 7 housekeeping genes can also help predict the history of human migrations. Population structure analysis based on MLST has revealed 7 modern population types of H. pylori, which derived from 6 ancestral populations. Interestingly, the incidence of gastric cancer is closely related to the distribution of H. pylori populations. The different incidence of gastric cancer can be partly attributed to the different genotypes of H. pylori circulating in different geographic areas. Although approaches by MLST and virulence factors are effective, these methods focus on a small number of genes and may miss information conveyed by the rest of the genome. Genome-wide analyses using DNA microarray or whole-genome sequencing technology give a broad view on the genome of H. pylori. In particular, next-generation sequencers, which can read DNA sequences in less time and at lower costs than Sanger sequencing, enabled us to efficiently investigate not only the evolution of H. pylori, but also novel virulence factors and genomic changes related to drug resistance.

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“…Although the prevalence of H. pylori in Okinawa is not significantly different from other parts of Japan (17,25), the incidence of gastric cancer (6.3 deaths/100,000 population) in Okinawa is the lowest in Japan (mean mortality rate of Japan, 11.8 deaths/100,000 population in 2009) ( . The different environmental factors and diets in Okinawa compared to mainland Japan are thought to be one reason for the lower incidence of gastric cancer (43).…”

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confidence: 99%

Association between Helicobacter pylori Virulence Factors and Gastroduodenal Diseases in Okinawa, Japan

et al. 2012

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The incidence of gastric cancer in Okinawa is lowest in Japan. Some previous reports using small number of strains suggested that the high prevalence of Helicobacter pylori with Western-type cagA in Okinawa compared to other areas in Japan might contribute to the low incidence of gastric cancer. It has still not been confirmed why the prevalence of Western-type cagA strains is high in Okinawa. We examined the association between the virulence factors of H. pylori and gastroduodenal diseases in Okinawa. The genotypes of cagA and vacA of 337 H. pylori strains were determined by PCR and gene sequencing.

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Helicobacter pylori infection in two areas in Japan with different risks for gastric cancer

Cited by 18 publications

References 30 publications

Transformed immortalized gastric epithelial cells by virulence factor CagA of Helicobacter pylori through Erk mitogen-activated protein kinase pathway

Transformed immortalized gastric epithelial cells by virulence factor CagA of Helicobacter pylori through Erk mitogen-activated protein kinase pathway

Molecular epidemiology, population genetics, and pathogenic role of Helicobacter pylori

Association between Helicobacter pylori Virulence Factors and Gastroduodenal Diseases in Okinawa, Japan

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