Helicobacter pylori infection increases the risk of developing preeclampsia: A meta-analysis of observational studies

Abstract

The findings of our study support that H. pylori infection doubles the risk of developing preeclampsia. The exact pathophysiological processes, however, remain poorly investigated and future experimental studies are needed to shed light on the underlying mechanisms.

Helicobacter pylori and extragastric diseases

“…The association between H. pylori and pre‐eclampsia was also demonstrated by a meta‐analysis by Nouollahpour Shiadeh et al, who included 8 studies published on this issue and confirmed by another larger meta‐analysis, including 14 observational studies and involving 9391 women, with an adjusted OR of 2.32 (95% CI: 1.55, 3.46). Prevalence of anti‐CagA antibodies was also higher in pregnancies complicated with pre‐eclampsia (3275 women, OR: 3.97 95% CI: 1.55, 10.19) …”

Perspectives, Commentaries, Consensus Reports, Grand Rounds, Meta-Analyses, Systematic Reviews, Narrative Reviews: Collecting useful information in one place

“…This month's issue of the journal contains a meta-analysis on the available evidence from observational studies that have explored Helicobacter pylori seropositivity status with preeclampsia, and provides an estimation of the odds of developing preeclampsia among women with H. pylori infection. 6 Of note, the study was designed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, 7 as recommended in a prior editorial on the topic of submitting meta-analytic papers to the International Journal of Clinical Practice. 8 The remainder of this month's issue of the journal contains additional reviews covering a variety of conditions and/or procedures, including the management of hyperkalaemia, 9 the treatment of hypothyroidism, 10 integrated left trial evaluation, 11 the use of endobronchial ultrasound trans-bronchial needle aspiration, 12 and a discussion on exocrine pancreatic insufficiency.…”

“…This month's issue of the journal contains a meta‐analysis on the available evidence from observational studies that have explored Helicobacter pylori seropositivity status with preeclampsia, and provides an estimation of the odds of developing preeclampsia among women with H. pylori infection . Of note, the study was designed according to the Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) guidelines, as recommended in a prior editorial on the topic of submitting meta‐analytic papers to the International Journal of Clinical Practice …”

Current understanding and management of Helicobacter pylori infection: an updated appraisal

“…Bellos et al . recently found that H. pylori infection in pregnant women increases the risk of developing preeclampsia, which is a potent contributor to maternal and fetal morbidity and mortality 11 . Another complication, hyperemesis gravidarum, can be found in up to 2.0% of women with early pregnancy and its onset has been associated with H. pylori infection 12 .…”