<i>Helicobacter pylori</i>is not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela

Santos, Iná S.; Boccio, José; Davidsson, Lena; Hernández-Triana, Manuel; Huanca-Sardinas, Elizabeth; Janjetic, Mariana; Moya-Camarena, Silvia Y.; Paez-Valery, Maria C; Ruiz-Álvarez, Vladimir; Valencia, Mauro E.; Valle, Neiva C. J.; Vargas-Pinto, Greta; Solano, Liseti; Thomas, J. Earl

doi:10.1017/s1368980009004789

Cited by 50 publications

(47 citation statements)

References 61 publications

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“…The findings of the present study were in agreement with those of Santos et al (2009) that there is no evidence to support the hypothesis that H. pylori contributes to anemia in children, adolescents, adults, or pregnant women in six Latin American countries. Neither did this study which showed no significant relationship between H. pylori and anemia.…”

Section: Discussionsupporting

confidence: 89%

Environmental risk factors affecting transmission of Helicobacter pylori infection in Egypt

2010

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Background Helicobacter pylori (H. pylori) infection varies remarkably between and within populations suggesting the role of socioeconomic-related environmental factors.Aim The aim of this study was to determine the prevalence of H. pylori among the studied population, to explore the effect of some environmental risk factors and lifestyle on the transmission of infection, and to study the association between this H. pylori bacterium and various noncontagious diseases. Method This cross-sectional study was conducted over 6 months in two Egyptian health clinics. Two hundred apparently healthy individuals from rural (Unshass) and urban (Nasr City) areas voluntarily participated in this study. A full detailed clinical assessment in the form of a questionnaire was designed for each individual to determine risk factors with specific emphasis on age, sex, and residence. The seroprevalence of H. pylori IgG antibodies was evaluated using the enzyme-linked immunosorbent assay (ELISA). Results In the urban group 28 subjects (28%) were H. pylori positive versus 54 subjects (54%) in the rural group. A significant relationship between H. pylori and poor sanitary conditions was detected; there was an association between H. pylori prevalence and gastric diseases, hepatic diseases, and hyperglycemia suggesting diabetes. Conclusion H. pylori infection was nearly twice as high in the rural group than in the urban one.

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Section: Discussionsupporting

confidence: 89%

Environmental risk factors affecting transmission of Helicobacter pylori infection in Egypt

2010

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“…South Africa: 87% [16], Egypt: 72% [17]), in Latin America (e.g. Bolivia: 78% [18]) and in some Asian countries (e.g. Pakistani: 92% [19]).…”

Section: Discussionmentioning

confidence: 99%

Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population

Bounder¹,

Boura²,

SalouaNadifiyine³

et al. 2017

JLS

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Abstract:Helicobacter pylori (H. pylori) colonize the gastric mucosa of 50% of the world's population. This infection is closely associated with the development of peptic ulcer disease and gastric cancer. The present study was conducted to assess the prevalence of H. pylori infection in Moroccan population and the risk to develop gastric precancerous lesions and gastric cancer. Totally, 298 patients were enrolled, 68 of asymptomatic subjects and 230 of patients with gastric diseases. Histological examination was effected to diagnostic gastric lesions and to detect H. pylori. ELISA was used to determine H. pylori status of patients. The prevalence of H. pylori within asymptomatic and symptomatic subjects was observed higher. A significant relationship was detected between H. pylori infection and the risk of gastric diseases (p-value < 0.0001). A meaningful association between chronic gastritis increasing and age was observed (p-value = 0.03). The risk to develop gastric cancer among infected patients was observed elevated with rate of 9%. Our results showed a high prevalence of H. pylori in both asymptomatic and gastric diseases patients. We noticed that chronic gastric infection increases with age. We remarked also that the risk to develop gastric cancer among infected patients was elevated in our population.

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“…This allowed the exclusion of common causes of iron deficiency such as gastrointestinal bleeding, peptic ulcer disease, extensive erosions and celiac disease. Furthermore, in contrast to other studies [16], [30], female adolescents with heavy menstrual blood loss were not included because menstrual iron loss is an important determinant of iron status in young women. Intestinal parasitic infections that lead to blood loss were also an exclusion criterion.…”

Section: Discussionmentioning

confidence: 99%

Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study

et al. 2013

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ObjectiveIron deficiency (ID) and iron deficiency anaemia (IDA) are global major public health problems, particularly in developing countries. Whilst an association between H. pylori infection and ID/IDA has been proposed in the literature, currently there is no consensus. We studied the effects of H. pylori infection on ID/IDA in a cohort of children undergoing upper gastrointestinal endoscopy for upper abdominal pain in two developing and one developed country.MethodsIn total 311 children (mean age 10.7±3.2 years) from Latin America - Belo Horizonte/Brazil (n = 125), Santiago/Chile (n = 105) - and London/UK (n = 81), were studied. Gastric and duodenal biopsies were obtained for evaluation of histology and H. pylori status and blood samples for parameters of ID/IDA.ResultsThe prevalence of H. pylori infection was 27.7% being significantly higher (p<0.001) in Latin America (35%) than in UK (7%). Multiple linear regression models revealed H. pylori infection as a significant predictor of low ferritin and haemoglobin concentrations in children from Latin-America. A negative correlation was observed between MCV (r = −0.26; p = 0.01) and MCH (r = −0.27; p = 0.01) values and the degree of antral chronic inflammation, and between MCH and the degree of corpus chronic (r = −0.29, p = 0.008) and active (r = −0.27, p = 0.002) inflammation.ConclusionsThis study demonstrates that H. pylori infection in children influences the serum ferritin and haemoglobin concentrations, markers of early depletion of iron stores and anaemia respectively.

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Helicobacter pyloriis not associated with anaemia in Latin America: results from Argentina, Brazil, Bolivia, Cuba, Mexico and Venezuela

Cited by 50 publications

References 61 publications

Environmental risk factors affecting transmission of Helicobacter pylori infection in Egypt

Environmental risk factors affecting transmission of Helicobacter pylori infection in Egypt

Epidemiology of Helicobacter pylori Infection and Related Gastric Pathologies in Moroccan Population

Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study

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