<i>Helicobacter pylori</i> May Have Only a Transient Presence in the Oral Cavity and on the Surface of Oral Cancer

Okuda, K; Ishihara, Kazuyuki; Miura, Tadashi; Katakura, Akira; Noma, Hiroyasu; Ebihara, Yoshinori

doi:10.1111/j.1348-0421.2000.tb02510.x

Cited by 61 publications

(70 citation statements)

References 19 publications

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“…In this work, the frequency of H. pylori was higher in gastric biopsies than in dental plaque, in agreement with those published by other authors, who detected the bacterium in 18% of dental plaques studied (13). Although the detection rate in the oral cavity in this study was low, the microorganism was detected with values similar to those published by other researchers (7,13) who have not been able to demonstrate the presence of bacteria or that have detected it in very low percentages (14). In the control group the microorganism was detected in mouth in a smaller percentage than in those patients who had gastrointestinal symptoms, which is in agreement with literature data (1).…”

Section: Among the Biology Molecular Techniques Polymerasesupporting

confidence: 92%

Molecular detection of Helicobacter pylori in oral samples from patients suffering digestive pathologies

Medina¹,

Medina²,

Martín³

et al. 2009

Med Oral

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Objective: to determine the simultaneous presence of H. pylori in both the oral cavity and gastric mucosal in patients suffering digestive pathologies and to establish the possible association between the presence of H. pylori in the oral cavity and the gingivoperiodontal pathology. Study design: Patients with gastric symptoms (case group) and asymptomatic patients (control group) seen at the Gastroenterology Department of Dr. Julio C. Perrando Hospital (Resistencia, Argentina) were selected. Dental plaque and saliva samples from both groups were obtained. In the case group, gastric biopsy samples were also taken. H. pylori was detected in gastric biopsies by histological stains, and Polymerase Chain Reaction (PCR) was carried out on the oral samples. Results: Among the 98 patients (43 cases and 55 controls), 196 oral samples (saliva 98, dental plaque 98) and 43 gastric biopsias were obtained. H. pylori was detected in oral samples in 18/98 patients, in gastric biopsies in 38/43 patients, and in both samples in 15/43 patients. Conclusions: The presence of H. pylori in the oral cavity of patients suffering digestive pathologies is more frequent in those patients harbouring a gingivoperiodontal disease, and this fact could represent an obstacle for the eradication of the bacterium. At the same time, it could constitute a risk factor for gastrointestinal reinfection after treatment.

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Section: Among the Biology Molecular Techniques Polymerasesupporting

confidence: 92%

Molecular detection of Helicobacter pylori in oral samples from patients suffering digestive pathologies

Medina¹,

Medina²,

Martín³

et al. 2009

Med Oral

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show abstract

“…It has been observed that such microorganisms have the ability to inhibit H. pylori growth in vitro. 42 Diffusible compounds secreted by Streptococcus mutans 46 and Streptococcus mitis 47 contribute to a dramatic decrease in H. pylori viability. However, microscopic observation has shown that this effect was caused by the conversion of H. pylori to nonculturable coccoid forms.…”

Section: Interactions Of Oral H Pylori With Microbial Fl Oramentioning

confidence: 99%

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

Krzyżek

Gościniak

2018

Dent. Med. Probl.

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The role of the oral cavity as a reservoir for Helicobacter pylori is still a controversial issue. There is a great number of articles indicating the presence of this pathogen in the oral cavity, but discrepancies among techniques for H. pylori detection and the variations in the patients tested often make it difficult to formulate a final verdict. Outer membrane proteins (OMPs) are one of the most important factors determining colonization of H. pylori in the oral cavity. Among them, the key role is attributed to BabA, SabA and NapA, all of which promote adherence and retention within this area. The oral cavity is characterized by the co-existence of numerous microorganisms which may potentially affect the physiology and morphology of H. pylori. The presence of coccoid-stimulating factors and relatively low levels of AI-2 in the early-to mid-stages of supragingival plaque allow dental H. pylori to colonize this niche as nonculturable spherical forms. On the other hand, subgingival plaque characterized by high numbers of periopathogens, capable of synthesizing high concentrations of AI-2, may favor the presence of mixed populations of spiral and coccoid H. pylori forms. This review article provides an up-to-date knowledge about the ability of oral H. pylori to interact both with the host and the local microflora of the oral cavity.

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“…This finding suggested that these resident oral bacteria might be effectively trapping newly transiting bacteria such as H. pylori in periodontal pockets of the oral cavity. Indeed, some reports indicated that H. pylori is a transient member of the oral microflora, since the growth of H. pylori in the oral cavity is influenced by various factors such as temperature, pH, oxidation-reduction potential, the availability of nutrients, flow of saliva and antimicrobial substances ( Okuda et al, 2000Okuda et al, , 2003. Furthermore, Imai et al (2009) indicated that P. gingivalis culture supernatant contained butyric acid in high concentrations, from 6.7 to 14.7 mM.…”

Section: Discussionmentioning

confidence: 99%

Destructive effects of butyrate on the cell envelope of Helicobacter pylori

Yonezawa

Osaki

Hanawa

et al. 2012

Journal of Medical Microbiology

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Helicobacter pylori can be found in the oral cavity and is mostly detected by the use of PCR techniques. Growth of H. pylori is influenced by various factors in the mouth, such as the oral microflora, saliva and other antimicrobial substances, all of which make colonization of the oral cavity by H. pylori difficult. In the present study, we analysed the effect of the cell supernatant of a representative periodontal bacterium Porphyromonas gingivalis on H. pylori and found that the cell supernatant destroyed the H. pylori cell envelope. As P. gingivalis produces butyric acid, we focused our research on the effects of butyrate and found that it significantly inhibited the growth of H. pylori. H. pylori cytoplasmic proteins and DNA were detected in the extracellular environment after treatment with butyrate, suggesting that the integrity of the cell envelope was compromised and indicating that butyrate has a bactericidal effect on H. pylori. In addition, levels of extracellular H. pylori DNA increased following treatment with the cell supernatant of butyric acid-producing bacteria, indicating that the cell supernatant also has a bactericidal effect and that this may be due to its butyric acid content. In conclusion, butyric acid-producing bacteria may play a role in affecting H. pylori colonization of the oral cavity.

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Helicobacter pylori May Have Only a Transient Presence in the Oral Cavity and on the Surface of Oral Cancer

Cited by 61 publications

References 19 publications

Molecular detection of Helicobacter pylori in oral samples from patients suffering digestive pathologies

Molecular detection of Helicobacter pylori in oral samples from patients suffering digestive pathologies

Oral Helicobacter pylori: Interactions with host and microbial flora of the oral cavity

Destructive effects of butyrate on the cell envelope of Helicobacter pylori

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