<i>Helicobacter pylori</i>Seropositivity among Swedish Adults with and without Abdominal Symptoms: A Population-Based Epidemiologic Study

Agréus, Lars; Engstrand, Lars; Svärdsudd, Kurt; Nyrén, Olof; Tibblin, Gösta

doi:10.3109/00365529509096323

Cited by 69 publications

(40 citation statements)

References 19 publications

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“…There were no statistical significant differences in terms of being H. pylori positive between the three symptom groups (33%, 33% and 48%, respectively, p ¼ 0.4), and there was no significant association between H. pylori seropositivity and education level or gender. 20 The 145 individuals with H. pylori serology did not differ in statistically significant ways from the other responders in the 1989 mail survey, in terms of age (mean 47.7 vs 48.9 years) or proportion with higher education (30.1% vs 30.9%), although there were significantly more women (63.4% vs 50.1%, p ¼ 0.003). This was due to the sampling strategy based on IBS, a diagnosis more common in women.…”

Section: Methodsmentioning

confidence: 94%

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Towards a healthy stomach? Helicobacter pylori prevalence has dramatically decreased over 23 years in adults in a Swedish community

et al. 2016

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Background: In Western countries the prevalence of Helicobacter pylori (H. pylori) infection may be declining but there is a lack of recent longitudinal population studies. We evaluated the changing epidemiology over a 23-year period in Sweden. Materials and methods: In 1989, the validated Abdominal Symptom Questionnaire (ASQ) was mailed to a random sample of inhabitants (ages 22-80 years) in a Swedish community, and 1097 (87%) responded. H. pylori serology was analysed in a representative subsample (n ¼ 145). Twenty-three years later, the ASQ was mailed again using similar selection criteria, and 388 out of 1036 responders had an upper endoscopy with assessment of H. pylori and corpus atrophy status. Results: The prevalence of positive H. pylori serology decreased from 37.9% (1989) to 15.8% (2012), corresponding to a decrease in odds of 75% per decade (odds ratio (OR): 0.25; 95% confidence interval (CI): 0.11-0.59, p ¼ 0.001) independent of age, gender, body mass index (BMI) and level of education, with a pattern consistent with a birth cohort effect. The prevalence increased with increasing age (p ¼ 0.001). The prevalence of H. pylori on histology in 2012 was 11.4% (95% CI 8.6-15.0). The prevalence of corpus atrophy on serology and/or histology in 2012 was 3.2% (95% CI 1.8-5.5); all cases were !57 years old. Conclusion: The stomach is healthier in 2012 compared with 1989. H. pylori prevalence in adults has decreased over the last two decades to a level where clinical management might be affected.

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Section: Methodsmentioning

confidence: 94%

“…The number of new participants in the 1995 and the 2011 studies are shown in Figure 2, sampling level A. 20 visited a research laboratory. Of those responders, 145 provided a blood sample for H. pylori serology (see Figure 1) and 55 (38%) were seropositive.…”

Section: Methodsmentioning

confidence: 99%

Towards a healthy stomach? Helicobacter pylori prevalence has dramatically decreased over 23 years in adults in a Swedish community

et al. 2016

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“…1 Comparison of data obtained from a representative sample of a Swedish municipality (n = 150; 50 asymptotic controls, 50 with dyspepsia and 50 with irritable bowel syndrome) published by Agrèus et al [21] with present data from chronic urticaria patiens (n = 100). The proportion of positive H. pylori (HP) serology in different age groups.…”

Section: Resultsmentioning

confidence: 99%

Prevalence of Helicobacter pylori–Associated Gastritis in Chronic Urticaria

Wedi¹,

Wagner

Werfel³

et al. 1998

Int Arch Allergy Immunol

126

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Background: Chronic urticaria and concurrent angioedema are frustrating problems for both physicians and patients. Methods: 100 patients with chronic urticaria (mean duration 33.3±48.2 months) attending the urticaria consulting hour of our Department of Dermatology within 1 year were carefully analyzed for pathogenesis to avoid extensive unnecessary diagnostic approach in the future. Results: In 43 cases a potential infectious trigger could be identified, 35 were of idiopathic origin, and 15 demonstrated pseudoallergic reactions to acetylsalicylic acid or food additives, 5 had antibodies to thyroid gland, and 2 had malignant diseases. Of patients with foci, 26 had Helicobacter pylori–associated gastritis, 9 chronic tonsillitis or sinusitis, 4 infections with Epstein–Barr virus or cytomegalovirus, 2 dental focal infections and 2 suffered from Yersinia infection. High prevalence of H. pylori gastritis was found since 47% of patients showed elevated H. pylori–specific IgA and/or IgG antibodies. 27 patients underwent endoscopy and in all but 1 (96%) antral H. pylori infection was found. In contrast, a prevalence rate of 37% among asymptomatic adults has been published. Disappearance (67%) or improvement of urticaria (24%) occurred in most antimicrobially treated patients after 3–12 weeks. In contrast, only 50% of untreated H. pylori–seropositive patients with chronic urticaria showed spontaneous remission or improvement within 12 weeks. Prevalence of H. pylori infection may even be underestimated since only 27/100 patients underwent endoscopy. It is suggested that H. pylori infection may be present at least in all seropositive subjects (47%). Moreover, we found H. pylori infection in 2 seronegative subjects demonstrating gastric complaints. Conclusions: Thus, measurement of H. pylori–specific antibodies and/or gastroscopy should be included in the diagnostic management of chronic urticaria to identify patients who may profit from eradication treatment with disappearance of long–standing and annoying urticaria symptomatology.

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“…30 These data are consistent with several earlier studies in which no association was observed between NUD and H pylori infection. 24,[31][32][33][34] For example, in a study of 180 consecutive blood donors with no evidence of organic disease, Holtmann et al 24 observed no association between H pylori and dyspepsia. Similarly, in a population-based study in Sweden, Agreus et al 32 observed no significant difference in the prevalence of H pylori infection among subjects with dyspepsia or irritable bowel syndrome and asymptomatic persons who were matched for age and sex.…”

Section: Commentmentioning

confidence: 99%

Dyspepsia in the Community Is Linked to Smoking and Aspirin Use but Not to Helicobacter pylori Infection

Nandurkar¹,

Talley²,

Xia³

et al. 1998

Arch Intern Med

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Helicobacter pyloriSeropositivity among Swedish Adults with and without Abdominal Symptoms: A Population-Based Epidemiologic Study

Abstract: Our data are incompatible with an important aetiologic role for H. pylori in functional dyspepsia.

Cited by 69 publications

References 19 publications

Towards a healthy stomach? Helicobacter pylori prevalence has dramatically decreased over 23 years in adults in a Swedish community

Towards a healthy stomach? Helicobacter pylori prevalence has dramatically decreased over 23 years in adults in a Swedish community

Prevalence of Helicobacter pylori–Associated Gastritis in Chronic Urticaria

Dyspepsia in the Community Is Linked to Smoking and Aspirin Use but Not to Helicobacter pylori Infection

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