<i>Helicobacter pylori</i> seropositivity and its association with incident all‐cause and Alzheimer's disease dementia in large national surveys

Beydoun, May A.; Beydoun, Hind A.; Elbejjani, Martine; Dore, Gregory A.; Zonderman, Alan B.

doi:10.1016/j.jalz.2018.04.009

Cited by 60 publications

(47 citation statements)

References 48 publications

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“…While higher levels of anti- H. pylori IgG antibodies in the CSF could be an indirect result of changes to the permeability of the BBB, these antibodies also correlated with lower mini-mental state examination scores compared to those of healthy controls (Kountouras et al, 2009). These conclusions remain controversial, however, as recent investigations found no increased risk of AD in H. pylori -infected patients (Fani et al, 2018) or only found increased risk in certain population groups, specifically in men and in higher socioeconomic status groups, both of which have higher incidence of complicating co-morbidities like cardiovascular disease (Beydoun et al, 2018).…”

Section: Bacterial Pathogens Associated With Neurodegenerationmentioning

confidence: 99%

Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

Patrick

Bell

Weindel

et al. 2019

Front. Cell. Infect. Microbiol.

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Despite major strides in personalized genomics, it remains poorly understood why neurodegenerative diseases occur in only a fraction of individuals with a genetic predisposition and conversely, why individuals with no genetic risk of a disorder develop one. Chronic diseases like Alzheimer's, Parkinson's, and Multiple sclerosis are speculated to result from a combination of genetic and environmental factors, a concept commonly referred to as the “multiple hit hypothesis.” A number of bacterial infections have been linked to increased risk of neurodegeneration, and in some cases, clearance of bacterial pathogens has been correlated with amelioration of central nervous system (CNS) deficits. Additionally, mutations in several genes known to contribute to CNS disorders like Parkinson's Disease have repeatedly been implicated in susceptibility to intracellular bacterial infection. Recent data has begun to demonstrate roles for these genes ( PARK2, PINK1 , and LRRK2 ) in modulating innate immune outcomes, suggesting that immune dysregulation may play an even more important role in neurodegeneration than previously appreciated. This review will broadly explore the connections between bacterial infection, immune dysregulation, and CNS disorders. Understanding this interplay and how bacterial pathogenesis contributes to the “multiple-hit hypothesis” of neurodegeneration will be crucial to develop therapeutics to effectively treat both neurodegeneration and infection.

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Section: Bacterial Pathogens Associated With Neurodegenerationmentioning

confidence: 99%

Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

Patrick

Bell

Weindel

et al. 2019

Front. Cell. Infect. Microbiol.

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“…Previous studies have found the infection of H pylori may increase the risk of peptic ulcer and gastric cancer 11,12 . In addition, infection of H pylori has been associated with extra‐gastric diseases, especially aging‐related diseases such as Alzheimer's disease, diabetes, and cardiovascular disease 13‐16 . However, the mechanisms underlying the association between H pylori infection and aging‐related diseases have not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

The relation between Helicobacter pylori immunoglobulin G seropositivity and leukocyte telomere length in US adults from NHANES 1999‐2000

et al. 2020

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Background Helicobacter pylori (H pylori) immunoglobulin G (IgG) seropositivity is prevalent but its relation with leukocyte telomere length (LTL), a cellular aging biomarker, is unclear. Methods Among 3,472 participants from the National Health and Nutrition Examination Survey (NHANES) cycle 1999‐2000, LTL was measured with the quantitative polymerase chain reaction. H pylori IgG was measured by enzyme‐linked immunosorbent assays and defined as seropositivity with an immune status ratio score > 0.9. We used linear regression models to examine the relation of H pylori IgG seropositivity with continuous LTL and logistic regression for the relation with short LTL (<10th percentile of the population distribution) adjusting for potential confounders. We stratified the analyses by a priori selected variables. Results Population prevalence of H pylori IgG seropositivity was 31.5% in the overall population with higher prevalence found in those with older age, other races than non‐Hispanic whites, lower education, and being born out of the United States. Continuous LTL was non‐significantly shorter in those with H Pylori IgG seropositivity versus seronegativity (mean difference = −40.3 bp, 95% CI: −112.4, 31.9). This difference was not significant after adjusting for potential confounders nor stratifying by potential effect modifiers. H Pylori IgG seropositivity was significantly associated with short LTL among the elderly (55‐75 years, adjusted OR: 3.06, 95% CI: 1.17, 7.99), but not in the overall population (OR: 1.28, 95% CI: 0.81‐2.02). Conclusion H Pylori IgG seropositivity was not associated with continuous LTL in the general population but may be associated with an excessively short LTL in the elderly.

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“…We hypothesized that H. pylori-infected individuals have more cortical thinning than non-infected individuals, even in a cognitively normal state. In a previous epidemiologic study, sex was shown to greatly in uence the effects of H. pylori on dementia [23]. In addition, socioeconomic status, chronic in ammation, and metabolic syndrome are associated with both H. pylori infection and neurodegeneration.…”

Section: Introductionmentioning

confidence: 90%

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

Park

Kim

Song

et al. 2020

Preprint

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Background An association between Helicobacter pylori (H. pylori) infection and dementia was reported in previous studies, however, the evidence is inconsistent. In the present study, the association between H. pylori infection and brain cortical thickness as a biomarker of neurodegeneration was investigated. Methods A cross-sectional study of 1,446 healthy adults who underwent a medical health check-up, including an esophagogastroduodenoscopy and 3.0 T magnetic resonance imaging was performed. H. pylori infection status was assessed based on histology. Multiple linear regression analysis was conducted to evaluate the relationship between H. pylori infection and brain cortical thickness. Results Males with H. pylori infection exhibited cortical thinning in the bilateral lateral temporal, lateral frontal, and right occipital areas compared with non-infected males after controlling for age, educational level, alcohol intake, smoking status, and intracranial volume. The association remained significant after further adjusting for inflammatory marker (C-reactive protein) and metabolic factors (obesity, dyslipidemia, fasting glucose, and blood pressure). However, an association between H. pylori infection and brain cortical thickness was not observed in females. Conclusions The findings indicate H. pylori infection is associated with neurodegenerative changes in cognitive normal males, independent of chronic inflammation or metabolic syndrome.

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Helicobacter pylori seropositivity and its association with incident all‐cause and Alzheimer's disease dementia in large national surveys

Cited by 60 publications

References 48 publications

Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

Exploring the “Multiple-Hit Hypothesis” of Neurodegenerative Disease: Bacterial Infection Comes Up to Bat

The relation between Helicobacter pylori immunoglobulin G seropositivity and leukocyte telomere length in US adults from NHANES 1999‐2000

Helicobacter Pylori Infection is Associated With Neurodegeneration in Cognitively Normal Males

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