Helicobacter pylori Seropositivity and Stool Antigen in Patients With Hyperemesis Gravidarum

Abstract

The objective of this paper is to investigate whether Helicobacter pylori is an etiologic factor in hyperemesis gravidarum. Thirty one patients with hyperemesis gravidarum and twenty nine pregnant controls without hyperemesis gravidarum were included in this prospective study. All pregnant women were examined both for Helicobacter pylori serum immunoglobulin G antibodies (HpIgG Ab), showing chronic infection, and Helicobacter pylori stool antigens (HpSA), showing active gastrointestinal colonization. Chi-square and Student t tests were used accordingly for statistical analysis. Helicobacter pylori seropositivity was 67.7% in the patients with hyperemesis gravidarum and 79.3% in the control group (χ2 = 1.02, P = .31). HpSA was detected in 22.6% of patients with hyperemesis gravidarum, whereas 6.9% of patients in the control group. The difference was not statistically significant (χ2 = 2.89, P = .08). In this study, no relation was found between Helicobacter pylori and hyperemesis gravidarum. The low social status of women in both groups could be one of the reasons for the high prevalence of Hp infection.

Helicobacter pylori infection amongst Arab Israeli women with hyperemesis gravidarum—a prospective, controlled study

“…17 In Turkey, Karadeniz et al found 68% and 79% H. pylori positivity in subjects with and without HG, respectively (p = not significant). 18 These negative studies are consistent with our findings, where the prevalence of H. pylori in a demographic subsection was unexpectedly found to be significantly higher than the general population and unrelated to HG.…”

Pregnancy outcomes in severe hyperemesis gravidarum in a multi-ethnic population

“…HG is associated with elevated levels of PAPP-A and free β -hCG, as reported by a recent study in the Turkish population (Derbent et al 2011) and numerous other parameters have been analysed in the literature; among those are allergies suggesting a possible autoimmune component and a restrictive diet (Mullin et al 2012). Helicobacter pylori have also been proposed as a possible aetiological factor for HG but this remains controversial (Karadeniz et al 2006).…”

Weight loss in women with hyperemesis gravidarum admitted in a tertiary hospital

“…5 Besides, it has more or less concordance with findings of prospective study carried out by Karadeniz et al (2005) with 22.6 percent prevalence of H. pylori infection among cases. 16 Purposive sampling technique was used for the selection of the study units which hinders the generalization of the study findings. HpSA test is for qualitative detection of H.pylori in stool sample and does not indicate the quantity of the antigen.…”