<i>Helicobacter pylori</i> seroprevalence in six different ethnic groups living in Amsterdam: The HELIUS study

Alberts, Catharina J.; Jeske, Rima; Martel, Catherine de; Hollander, Wouter J. den; Michel, Angelika; Prins, Maria; Snijder, Marieke B.; Loeff, Maarten F. Schim van der; Waterboer, Tim

doi:10.1111/hel.12687

Cited by 14 publications

(10 citation statements)

References 51 publications

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“…The majority of individuals were infected with H. pylori and most of them were cagA+ , suggesting potential mechanisms of aiding the entry of other pathogens [ 42 ]. Our data are consistent with the results of a systematic review by Morais and colleagues [ 43 ] as well as the findings of a recent Dutch study, highlighting that H. pylori seroprevalence among first-generation migrants was high and remains elevated among second-generation migrants (i.e., those born in the Netherlands) [ 44 ]. Moreover, in our cohort, a higher rate of H. pylori infection was observed among intestinal parasites infected individuals compared to uninfected subjects.…”

Section: Discussionsupporting

confidence: 92%

Concomitant Infection of Helicobacter pylori and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy

Pomari

Ursini

Silva

et al. 2020

JCM

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Background: Helicobacter pylori and intestinal parasites are estimated to infect with high burden worldwide. However, their concomitant infections are poorly determined in industrialized countries, such as Italy. In this study we aim at describing the presence of H. pylori as well as the proportion of coinfections with intestinal parasites among subjects who attended a referral center for tropical diseases in Northern Italy. Methods: This was a case-control study. Screening for H. pylori and parasites was performed on stool samples of 93 adults from different geographical origin (Africa, Asia, South-America, East-Europe and Italy). H. pylori infection was examined by CLIA and its cagA positivity was determined by rtPCR. Intestinal parasites (i.e., protozoa and helminths) were examined by microscopy and rtPCR. Results: Sixty-one out of 93 patients (66%) were positive to H. pylori and 31 (33%) were cagA+. Among H. pylori positives, 45 (74%) had a concomitant infection. The coinfection H. pylori–Blastocystis was the most frequent one, followed by H. pylori–E. coli. Multivariable logistic regression showed that positivity to H. pylori was associated with having a coinfection. Conclusion: Our data suggested that H. pylori and intestinal parasitic infections are fairly common in subjects who attended a referral center for tropical diseases in Northern Italy. The high rate of H. pylori infection, and especially the positivity to the virulent cagA+, should be taken into consideration in subjects undergoing screening for parasitic infections.

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Section: Discussionsupporting

confidence: 92%

Concomitant Infection of Helicobacter pylori and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy

Pomari

Ursini

Silva

et al. 2020

JCM

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“…All ethnic minority groups had a significantly higher risk of being H pylori seropositive compared to the Dutch group. All groups, except the Moroccans, had a significantly higher proportion of individuals with CagA + H pylori strains compared to the Dutch participants 1 …”

Section: Helicobacter Pylori Prevalence Worldwidementioning

confidence: 83%

Review: Epidemiology of Helicobacter pylori

et al. 2020

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This review summarizes the recent knowledge on the epidemiology of Helicobacter pylori and the potential modes of transmission. In addition to English language publications, the authors have included original full‐text publications from Russia and Latin America published in the original languages. High H pylori prevalence has been reported in Russia, Jordan, Iran, China, and Latin American countries as well as in Arctic populations in Canada. Indigenous inhabitants in the Arctic were found to be infected substantially more frequently than non‐indigenous inhabitants. In Amsterdam, the Netherlands, the ethnic minority groups were at a significantly higher risk of being H pylori seropositive compared to the Dutch population. For the first time, data on the prevalence from Armenia have been published indicating 41.5% H pylori prevalence. Convincing evidence on the decline of H pylori prevalence in Southeast Hungary and Taiwan was published. A study from Chile suggested high infection rates in newborns during the first month after birth. Two meta‐analyses covered the potential correlation between H pylori and periodontal diseases, therefore addressing the potential oro‐oral transmission rates. Periodontal disease was found to be more prevalent in H pylori‐infected subjects. Other studies addressed the potential role of drinking water and food products as well as socioeconomic factors in transmitting the infection. Several studies in Asia addressed annual reinfection rates of H pylori, ranging from 1.5% in China to 3.1% in Korea. Finally, a review was published on the current evidence and future perspective of analysing H pylori in ancient human remains by a metagenomic approach.

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“…Helicobacter pylori infection is common, affecting >50% of the global population with a higher incidence in developing countries (Hooi et al, 2017). The prevalence of H. pylori infection varies by age, ethnicity and living conditions (Seyda et al, 2007;Laszewicz et al, 2014;Alberts et al, 2020), and most cases occur in childhood (Banatvala et al, 1993). Only a small percentage of people develop pathological conditions related to H. pylori infection such as chronic gastritis, peptic ulcers, gastric adenocarcinoma, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma (Wang et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Role of the Gastric Microbiome in Gastric Cancer: From Carcinogenesis to Treatment

et al. 2021

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The development of sequencing technology has expanded our knowledge of the human gastric microbiome, which is now known to play a critical role in the maintenance of homeostasis, while alterations in microbial community composition can promote the development of gastric diseases. Recently, carcinogenic effects of gastric microbiome have received increased attention. Gastric cancer (GC) is one of the most common malignancies worldwide with a high mortality rate. Helicobacter pylori is a well-recognized risk factor for GC. More than half of the global population is infected with H. pylori, which can modulate the acidity of the stomach to alter the gastric microbiome profile, leading to H. pylori-associated diseases. Moreover, there is increasing evidence that bacteria other than H. pylori and their metabolites also contribute to gastric carcinogenesis. Therefore, clarifying the contribution of the gastric microbiome to the development and progression of GC can lead to improvements in prevention, diagnosis, and treatment. In this review, we discuss the current state of knowledge regarding changes in the microbial composition of the stomach caused by H. pylori infection, the carcinogenic effects of H. pylori and non-H. pylori bacteria in GC, as well as the potential therapeutic role of gastric microbiome in H. pylori infection and GC.

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Helicobacter pylori seroprevalence in six different ethnic groups living in Amsterdam: The HELIUS study

Cited by 14 publications

References 51 publications

Concomitant Infection of Helicobacter pylori and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy

Concomitant Infection of Helicobacter pylori and Intestinal Parasites in Adults Attending a Referral Centre for Parasitic Infections in North Eastern Italy

Review: Epidemiology of Helicobacter pylori

Role of the Gastric Microbiome in Gastric Cancer: From Carcinogenesis to Treatment

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