Helicobacter pylori Status and Symptom Assessment Two Years after Eradication in Pediatric Patients from a High Prevalence Area

Abstract

The 12.8% per year reinfection rate in childhood at 2 years that we observed should prompt a re-evaluation of H. pylori status even after a successful eradication. Living in an H. pylori high prevalence area increases the annual risk of reinfection by approximately fourfold over the annual risk in H. pylori low prevalence areas.

High Rate of Helicobacter pylori Reinfection in Children and Adolescents

“…Only four articles have reported on the risk factors associated with reinfection in childhood [19][20][21]23]. Consistent with the findings of Rowland et al [19] our data did not show that the risk of reinfection depended on the age of the index child, number of siblings, low socioeconomic status, or living conditions.…”

“…To our knowledge, only five studies are reported on reinfection rate and risk factors of reinfection in childhood [19][20][21][22][23], and there are few data on the long-term efficacy of treatment in children. To our knowledge, only five studies are reported on reinfection rate and risk factors of reinfection in childhood [19][20][21][22][23], and there are few data on the long-term efficacy of treatment in children.…”

Helicobacter pylori and recurrent abdominal pain in children: Is there any relation?

“…22 In the present study, vomiting was significantly higher in H. pylori infected children than in non-infected ones (24.04% versus 8.6%, p=0.001). 15,30,40 However, we did not find any significant difference in the incidence of nausea, 37 or diarrhea. 35 Other studies reported positive association between diarrhea and H. pylori infection in children.…”

“…Epigastric pain as a localizing symptom associated with H. pylori infection has been documented in other studies as well. 6,[35][36][37] However, epigastric pain was less frequently encountered in the study by Kalach et al 38 Upper GI endoscopy and biopsy was carried out in 10 children with persistent epigastric pain and vomiting. It revealed a significantly higher incidence of nodular gastritis in H. pylori infected cases especially among older children (p<0.05), and indicates histopathological evolution of the lesions with chronicity of infection.…”

Correlation of Helicobacter Pylori Infection With IL-8 and Recurrence of Abdominal Pain: Our Experience from an Endemic Area

“…A large body of evidence shows that the prevalence of H. pylori was significantly higher among children with reflux oesophagitis than in children with hyperemic gastropathy [31] . However, we could not find any significant difference between H. pylori positive and negative cases in the incidence of nausea, and vomiting [32] , or diarrhea [33] . However, other studies reported positive correlation between the infection and diarrhea [3,18] , and in some cases it correlates with vomiting [3] .…”